La candidiasis es una enfermedad micótica debida a levaduras pertenecientes al género Candida. Dentro del gran conjunto de microorganismos que colonizan al ser humano, Candida albicans es el agente etiológico más comúnmente detectado ya que habita como comensal en las superficies mucosas y la piel. C. albicans participa en procesos de fermentación de azúcares y asimilación de nutrientes, pero, en algunas ocasiones se relaciona con procesos patológicos. En los últimos años los avances tecnológicos y médicos; así como el aumento en la incidencia de infecciones por el virus de la inmunodeficiencia humana, el auge creciente de la terapia inmunomoduladora y el uso de antibióticos de amplio espectro durante largos períodos de tiempo se han convertido en los factores de riesgo más importantes para la creciente incidencia de infecciones por microorganismos del género Candida. Debido a esto, resulta imperativo el conocimiento de esta enfermedad y sus formas clínicas más importantes, así como el abordaje diagnóstico y el tratamiento actual; información que recolectamos en este documento para brindar una visión general sobre esta patología.

Chromobacterium violaceum is a facultative anaerobic, Gram-negative rod found in different ecosystems, especially tropical and subtropical areas. Human infections are rare, and just a few cases have been reported in literature. In this paper, we present the first non-lethal infection due to Chromobacterium violaceum, in an adult male with polycystic kidney disease in Colombia. Periareolar soft tissue infection was documented with isolation of Chromobacterium violaceum. Clinical manifestations, treatment, and outcome are shown.

Objective: To determine relationship between clinical characteristics, laboratory results and treatments with 12 month mortality in COVID 19. Materials and methods: A retrospective cohort study was conducted in three hospitals in Colombia. Odds ratios (OR) were calculated using multivariate logistic regression analysis with outcome variable mortality at 12 months. Results: A total of 1194 patients were included out of 4344 potential eligible subjects, average age was 57.7 years. The group of patients who died at 12 months showed a lymphocyte count of 922.6 (SD:572.32) compared to 1200.1 (SD:749.45) in the group of survivors (p<0.001). Hemoglobin averaged 2.1 g/dl less in the patients who died compared to the control group (14.5 vs. 12.4; p<0.001). The blood urea nitrogen (33.3 vs. 19.3; p70 years OR:7.2 (95%CI:3.9-13.3) and adjusted OR:1.05 (95%CI:1.01-1.08) (p=0.023), Charlson index >4 OR:7.8 (95%CI:4.3-14.1) and adjusted OR:1.35 (95%CI:1.1-1.67) (p=0.005), dexamethasone OR:0.3 (95%CI:0.2-0.6) and adjusted OR:0.3 (95%CI:0.14-0.65) (p=0.002) and pronation OR:0.3 (95%CI:0.1-1) and adjusted OR:0.4 (95%CI:0.08-1.87) (p=0.242). Conclusions: The increased risk of death 12 months after acute SARS CoV 2 infection is associated with clinical variables such as age >70 years and Charlson index >4. Use of prone ventilation and dexamethasone were associated with increased survival.

AA amyloidosis is a complication related to several chronic inflammatory conditions like cancer, autoimmune diseases and infections, among others. The disease implicates amyloid fibrils deposit in tissues leading to organ failure. Renal involvement has been closely associated with amyloidosis and sometimes with tuberculosis too. Therefore, it is important to achieve a renal biopsy that allows elucidating the etiology of the clinical picture in order to provide the correct treatment to the patients. In this paper, we present a case of renal amyloidosis secondary to pulmonary tuberculosis which debuted as nephrotic syndrome.

Objective: To determine the diagnostic yields of the different types of cell indices alone or in combination with C-reactive-protein(CRP) to distinguish between Pulmonary-tuberculosis(PT) and community-acquired-pneumonia(CAP). Methods: A retrospective cohort study was conducted in a high-complexity care center in Colombia, evaluating different types of cell indices in PT and CAP patients. A-receiver-operating-characteristic (ROC)-curve was plotted, and the area-under ROC-curve was calculated for each of these indices, as well as for CRP and procalcitonin values.Results: A total of 544 subjects were included in the final analysis. Of these, 270(49,6%) were diagnosed with PT and 274(50,4%) with CAP. Patients with CAP had significantly higher levels of leukocytes, neutrophils, monocytes, hemoglobin, hematocrit, and platelets than patients with PT (p < 0,05for-all-comparisons). Procal-citonin did not show significant differences between the groups (p=0,061). CRP has the highest ROC-curve for differentiating between PT and CAP, with ROC-curve of 0,76 (95%CI:0,71-0,88) and 0,75 (95%CI:0,71-0,80), respectively. Procalcitonin did not show discriminatory power for these two diseases, with an ROC-curve of 0,60 (95%CI:0,50-0,71). Conclusion: CRP and blood-cell-markers were the best markers to differentiate between patients with PT and CAP. The performance of these markers was acceptable, suggesting that they could be useful in clinical setting for suspected tuberculosis or CAP.