Infectious and inflammatory pulmonary diseases are a leading cause of morbidity and mortality worldwide. Although infrequently used in this setting, molecular imaging may significantly contribute to their diagnosis using techniques like single photon emission tomography (SPET), positron emission tomography (PET) with computed tomography (CT) or magnetic resonance imaging (MRI) with the support of specific or unspecific radiopharmaceutical agents. ¹⁸F-Fluorodeoxyglucose (¹⁸F-FDG), mostly applied in oncological imaging, can also detect cells actively involved in infectious and inflammatory conditions, even if with a low specificity. SPET with nonspecific (e.g., ⁶⁷Gallium-citrate (⁶⁷Ga citrate)) and specific tracers (e.g., white blood cells radiolabeled with ¹¹¹Indium-oxine (¹¹¹In) or ^99mTechnetium (^99mTc)) showed interesting results for many inflammatory lung diseases. However, ⁶⁷Ga citrate is unfavorable by a radioprotection point of view while radiolabeled white blood cells scan implies complex laboratory settings and labeling procedures. Radiolabeled antibiotics (e.g., ciprofloxacin) have been recently tested, although they seem to be quite unspecific and cause antibiotic resistance. New radiolabeled agents like antimicrobic peptides, binding to bacterial cell membranes, seem very promising. Thus, the aim of this narrative review is to provide a comprehensive overview about techniques, including PET/MRI, and tracers that can guide the clinicians in the appropriate diagnostic pathway of infectious and inflammatory pulmonary diseases.

Aim: The aim of this mini-review was to summarize the role of positron emission tomography/computed tomography (PET/CT) with ¹⁸Fluorine-fluorodeoxyglucose ([¹⁸F]FDG) in inflammatory and infective processes, based on the published scientific evidence. Methods: We analysed clinical indications, patient preparation, image acquisition protocols, image interpretation, pitfalls and how to make the report of cardio-vascular diseases, musculoskeletal diseases and other inflammatory and infective systemic diseases. Results of this analysis are shown in practical tables, easy to understand for daily routine consultation. Conclusions: Despite [¹⁸F]FDG is currently used in several inflammatory and infective diseases, standardized interpretation criteria are still needed in most cases. It is, therefore, foreseen the execution of multicentre clinical studies that, by adopting the same acquisition and interpretation criteria, may contribute to the standardization of this imaging modality.