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Mesenchymal stem cells have proven to be a promising alternative to conventional steroids to treat canine inflammatory bowel disease (IBD). However, their administration requires a washout period of immunosuppressive drugs that can lead to an exacerbation of the symptoms. Therefore, the feasibility and effects of the combined application of stem cells and prednisone in IBD-dogs without adequate response to corticosteroids was evaluated for the first time in this study over a long- term follow up. Two groups of dogs with IBD, one without treatment and another with prednisone treatment, received a single infusion of stem cells. The clinical indices, albumin and cobalamin were determined prior to the infusion and after one, three, six and 12 months. In both groups, all parameters significantly improved at each time point. In parallel, the steroid dosage was gradually reduced until it was suppressed in all patients a year after the cell therapy. Therefore, cell therapy can significantly and safely improve the disease condition in dogs with IBD receiving or not receiving prednisone. Furthermore, the steroid dosage can be significantly reduced or cancelled after the stem cell infusion. Their beneficial effects are stable over time and are long lasting.
José Cristóbal; Francisco Duque; Jesús Usón-Casaús; Patricia Ruiz; Esther Nieto; Eva Pérez-Merino. Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Animals 2021, 11, 2061 .
AMA StyleJosé Cristóbal, Francisco Duque, Jesús Usón-Casaús, Patricia Ruiz, Esther Nieto, Eva Pérez-Merino. Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids. Animals. 2021; 11 (7):2061.
Chicago/Turabian StyleJosé Cristóbal; Francisco Duque; Jesús Usón-Casaús; Patricia Ruiz; Esther Nieto; Eva Pérez-Merino. 2021. "Effects of Allogeneic Mesenchymal Stem Cell Transplantation in Dogs with Inflammatory Bowel Disease Treated with and without Corticosteroids." Animals 11, no. 7: 2061.
The aim was to evaluate if medetomidine and dexmedetomidine affected arterial ovarian blood flow in dogs. The dogs were randomly assigned to two different groups. In Group 1, medetomidine (10 µg/kg) was administered intramuscularly and, in Group 2, dexmedetomidine (5 µg/kg) was used. After a preliminary exam, arterial blood pressure (BP) was measured and a duplex Doppler ultrasonographic examination of both ovarian arteries was performed. Twenty minutes after the administration of medetomidine or dexmedetomidine, BP and ovarian Doppler ultrasonography were repeated. High quality tracings of ovarian artery flow velocity were obtained in all dogs and Doppler parameters: Peak Systolic Velocity (PSV), End Diastolic Velocity (EDV) and Resistive Index (RI) were measured before and after drug administration in the left (LO) and right (RO) ovaries. PSV and EDV values decreased significantly after drug administration (p < 0.05) compared to the non-sedated values, but no differences were found between the LO and RO (p > 0.05). The RI was not affected by drugs administration in neither of the groups studied (p > 0.05). In conclusion, the administration of medetomidine or dexmedetomidine causes a decrease in blood flow velocity in the ovarian artery and may be a good choice to avoid excessive bleeding prior surgeries in which ovariectomy.
Paloma Nicolás-Barceló; Martina Facchin; Fernando Martínez-Taboada; Rafael Barrera; José Cristóbal; Mario González; Ángela Durán-Galea; Beatriz Macías-García; Francisco Duque. Effects of Sedation with Medetomidine and Dexmedetomidine on Doppler Measurements of Ovarian Artery Blood Flow in Bitches. Animals 2021, 11, 538 .
AMA StylePaloma Nicolás-Barceló, Martina Facchin, Fernando Martínez-Taboada, Rafael Barrera, José Cristóbal, Mario González, Ángela Durán-Galea, Beatriz Macías-García, Francisco Duque. Effects of Sedation with Medetomidine and Dexmedetomidine on Doppler Measurements of Ovarian Artery Blood Flow in Bitches. Animals. 2021; 11 (2):538.
Chicago/Turabian StylePaloma Nicolás-Barceló; Martina Facchin; Fernando Martínez-Taboada; Rafael Barrera; José Cristóbal; Mario González; Ángela Durán-Galea; Beatriz Macías-García; Francisco Duque. 2021. "Effects of Sedation with Medetomidine and Dexmedetomidine on Doppler Measurements of Ovarian Artery Blood Flow in Bitches." Animals 11, no. 2: 538.