Objectives: Percutaneous ablation is an expanding, minimally invasive approach for small- to medium-sized renal masses. The purpose of this study is to review safety, and mid-term efficacy of percutaneous microwave ablation (MWA) for Renal Cell Carcinoma (RCC) treatment using a high power microwave system. Methods and materials: Institutional database research identified 50 consecutive patients with a single lesion resembling renal cell carcinoma in CT and MRI who underwent percutaneous microwave ablation using a high power microwave system. All patients underwent biopsy on the same session with ablation using an 18G semi-automatic soft tissue biopsy needle. Contrast-enhanced computed tomography or magnetic resonance imaging was used for post-ablation follow-up. Patient and tumour characteristics, microwave technique, complications and pattern of recurrence were evaluated. Results: Mean patient age was 74 years (male–female: 31–19). Average lesion size was 3.1 cm (range 2.0–4.3 cm). Biopsy results report RCC (n = 48), inflammatory myofibroblastic tumour (n = 1), and non-diagnostic sample (n = 1). The 3-year overall survival was 95.8% (46/48). Two patients died during the 3-year follow-up period due to causes unrelated to the MW ablation and to the RCC. Minor complications including haematomas requiring nothing but observation occurred at 4% (2/50) of the cases. Local recurrence of 6.25% (3/48) was observed with 2/3 cases being re-treated achieving a total clinical success of 97.9% (47/48 lesions). Conclusions: Percutaneous microwave ablation of RCC using a high power microwave system is a safe and efficacious technique for the treatment of small- to medium-sized renal masses.

Background and objective: Cardiac magnetic resonance (CMR) is a key tool for cardiac work-up. However, arrhythmia can be responsible for arrhythmia-related artifacts (ARA) and increased scan time using segmented sequences. The aim of this study is to evaluate the effect of cardiac arrhythmia on image quality in a comparison of a compressed sensing real-time (CS_rt) cine sequence with the reference prospectively gated segmented balanced steady-state free precession (Cine_ref) technique regarding ARA. Methods: A total of 71 consecutive adult patients (41 males; mean age = 59.5 ± 20.1 years (95% CI: 54.7–64.2 years)) referred for CMR examination with concomitant irregular heart rate (defined by an RR interval coefficient of variation >10%) during scanning were prospectively enrolled. For each patient, two cine sequences were systematically acquired: first, the reference prospectively triggered multi-breath-hold Cine_ref sequence including a short-axis stack, one four-chamber slice, and a couple of two-chamber slices; second, an additional single breath-hold CS_rt sequence providing the same slices as the reference technique. Two radiologists independently assessed ARA and image quality (overall, acquisition, and edge sharpness) for both techniques. Results: The mean heart rate was 71.8 ± 19.0 (SD) beat per minute (bpm) (95% CI: 67.4–76.3 bpm) and its coefficient of variation was 25.0 ± 9.4 (SD) % (95% CI: 22.8–27.2%). Acquisition was significantly faster with CS_rt than with Cine_ref (Cine_ref: 556.7 ± 145.4 (SD) s (95% CI: 496.7–616.7 s); CS_rt: 23.9 ± 7.9 (SD) s (95% CI: 20.6–27.1 s); p < 0.0001). A total of 599 pairs of cine slices were evaluated (median: 8 (range: 6–14) slices per patient). The mean proportion of ARA-impaired slices per patient was 85.9 ± 22.7 (SD) % using Cine_ref, but this was figure was zero using CS_rt (p < 0.0001). The European CMR registry artifact score was lower with CS_rt (median: 1 (range: 0–5)) than with Cine_ref (median: 3 (range: 0–3); p < 0.0001). Subjective image quality was higher in CS_rt than in Cine_ref (median: 3 (range: 1–3) versus 2 (range: 1–4), respectively; p < 0.0001). In line, edge sharpness was higher on CS_rt cine than on Cine_ref images (0.054 ± 0.016 pixel⁻¹ (95% CI: 0.050–0.057 pixel⁻¹) versus 0.042 ± 0.022 pixel⁻¹ (95% CI: 0.037–0.047 pixel⁻¹), respectively; p = 0.0001). Conclusion: Compressed sensing real-time cine drastically reduces arrhythmia-related artifacts and thus improves cine image quality in patients with arrhythmia.

The purpose of this study was to evaluate the diagnostic performance of myocardial extracellular volume (ECV) quantification using dual-source photon-counting detector computed tomography (PCCT) compared to cardiac magnetic resonance imaging (MRI) for assessing the severity of myocardial fibrosis in patients with hypertrophic cardiomyopathy (HCM). Patients with HCM due to sarcomere mutations underwent cardiac computed tomography angiography (CCTA) using a first-generation PCCT scanner, followed by comprehensive cardiac MRI. The CCTA protocol included a late iodine enhancement acquisition in spectral mode, 5 min after contrast media injection. ECV was calculated from the iodine ratio of the myocardium and blood pool on late iodine enhancement PCCT images. Cardiac MRI biomarkers included T1 mapping, ECV, and late gadolinium enhancement percentage (LGE). Diagnostic capabilities of PCCT were estimated using sensitivity, specificity, accuracy, interobserver agreement for myocardial fibrosis, area under the receiver operating characteristic curve (AUC) analyses for optimal thresholds, and correlations between tissue characteristics, functional capacity, and biomarkers. Thirty patients were retrospectively included. There were 22 men and eight women with a mean age of 59 ± 13.8 (standard deviation [SD]). The mean dose length product of late enhancement PCCT scanning was 105 ± 45 (SD) mGy.cm. No significant differences were found between global PCCT-derived ECV (30.0 ± 4.8 [SD] %) and MRI-derived ECV (30.62 ± 4.2 [SD] %) (P = 0.59). Linear regression revealed a strong segmental correlation between PCCT and MRI (basal, r = 0.89; mid-ventricular, r = 0.85; apical, r = 0.85; P < 0.001). An optimal PCCT-derived ECV threshold of 33.4 % allowed the diagnosis of LGE ≥ 15 % with 80 % sensitivity, 76 % specificity, and an AUC of 0.77, not significantly different from MRI-derived ECV (threshold 33.9 %; sensitivity, 80 %; specificity, 76 %, AUC, 0.80; P = 0.176). PCCT-derived ECV correlated with peak VO₂ (r = -0.76) and NT-proBNP levels (r = 0.59). PCCT-derived ECV shows promise for quantifying myocardial fibrosis in HCM, offering a valuable non-invasive alternative to cardiac MRI, especially for patients with contraindications or those requiring combined CCTA and myocardial assessment.

Background and objective: Real-time compressed sensing cine (CS_rt) provides reliable quantification for both ventricles but may alter image quality. The aim of this study was to assess image quality and the accuracy of left (LV) and right ventricular (RV) volumes, ejection fraction and mass quantifications based on a retrogated segmented compressed sensing 2D cine sequence (CS_rg). Methods: Thirty patients were enrolled. Each patient underwent the reference retrogated segmented steady-state free precession cine sequence (SSFP_ref), the real-time CS_rt cine and the segmented retrogated prototype CS_rg sequence providing the same slices. Functional parameters quantification and image quality rating were performed on SSFP_ref and CS_rg images sets. The edge sharpness, which is an estimate of the edge spread function, was assessed for the three sequences. Results: The mean scan time was: SSFP_ref = 485.4 ± 83.3 (SD) s (95% CI: 454.3–516.5) and CS_rg = 58.3 ± 15.1 (SD) s (95% CI: 53.7–64.2) (p < 0.0001). CS_rg subjective image quality score (median: 4; range: 2–4) was higher than the one provided by CS_rt (median: 3; range: 2–4; p = 0.0008) and not different from SSFP_ref overall quality score (median: 4; range: 2–4; p = 0.31). CS_rg provided similar LV and RV functional parameters to those assessed with SSFP_ref (p > 0.05). Edge sharpness was significantly better with CS_rg (0.083 ± 0.013 (SD) pixel⁻¹; 95% CI: 0.078–0.087) than with CS_rt (0.070 ± 0.011 (SD) pixel⁻¹; 95% CI: 0.066–0.074; p = 0.0004) and not different from the reference technique (0.075 ± 0.016 (SD) pixel⁻¹; 95% CI: 0.069–0.081; p = 0.0516). Conclusions: CS_rg cine provides in one minute an accurate quantification of LV and RV functional parameters without compromising subjective and objective image quality.