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Mr. Konstantinos Papaioannou
Örebro University

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0 Metabolism
0 Muscle
0 Physical Activity and Health
0 diet pattern
0 metainflammation

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Profile ImageH. Kainulainen Institut für Pharmakologie ...
Profile ImageBernardo M. Oliveira Unit of Muscle Biology, Depa...
Profile ImageO. Ritvos Department of Bacteriology a...
Profile ImageJuha Hulmi Faculty of Sport and Health ...
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Journal article
Published: 16 August 2021 in Nutrients
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Healthy Diet and physical activity may play important roles in the maintenance of muscle health during aging. The aim of the present study was to explore the impact of adherence to healthy dietary patterns on sarcopenia risk in a sample of physically active older men and women, while considering adherence to guidelines on muscle strengthening activities (MSA) and protein intake. Based on a sample of 191 physically active men and women (65–70 years), dietary intake was assessed using a 90-items food-frequency-questionnaire (FFQ) and Healthy Diet Score (HDS) was calculated. Physical activity was assessed by accelerometry and self-report. A sarcopenia risk score (SRS) was derived based on three indicators of muscle health: muscle mass was assessed using bioelectrical impedance and handgrip strength and 5 times sit-to-stand (5-STS) were determined by standardized procedures. Analysis of covariance (ANCOVA) was used to examine differences in SRS and its components across sex-specific tertiles of HDS, with adjustments for covariates including total energy intake, protein intake and MSA. A significant main effect (p< 0.05) of HDS on SRS was observed, where those belonging to the highest HDS tertile had lower SRS compared to those in the lowest tertile. A corresponding significant effect was observed for 5-STS performance, with better performance in those with the highest HDS adherence compared to those with the lowest. The present study supports guidelines emphasizing diet quality beyond amounts of macro- and micronutrients in the prevention of age-related deterioration of muscle health. Importantly, the benefits from healthy dietary patterns are evident in older adults who already adhere to guidelines for health-enhancing physical activity.

ACS Style

Konstantinos-Georgios Papaioannou; Andreas Nilsson; Lena Maria Nilsson; Fawzi Kadi. Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults. Nutrients 2021, 13, 2813 .

AMA Style

Konstantinos-Georgios Papaioannou, Andreas Nilsson, Lena Maria Nilsson, Fawzi Kadi. Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults. Nutrients. 2021; 13 (8):2813.

Chicago/Turabian Style

Konstantinos-Georgios Papaioannou; Andreas Nilsson; Lena Maria Nilsson; Fawzi Kadi. 2021. "Healthy Eating Is Associated with Sarcopenia Risk in Physically Active Older Adults." Nutrients 13, no. 8: 2813.

Physiology
Published: 05 February 2021 in Frontiers in Physiology
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The study aimed to examine sex-specific associations between objectively measured sedentary patterns and pro- and anti-inflammatory biomarkers in older adults when considering the moderating impact of physical activity (PA). Accelerometer-based monitoring of sedentary patterns and PA was conducted in a population of older men (n = 83; age: 67.4 ± 1.5; height: 178.7 ± 6.6 cm; weight: 80.9 ± 10.6 kg) and women (n = 146; age: 67.4 ± 1.6; height: 164.2 ± 6.1 cm; weight: 64.6 ± 10.1 kg) aged 65–70. Blood samples were collected for the assessment of the inflammatory biomarkers C-reactive protein (CRP), fibrinogen, interleukin-6 (IL-6), IL-10, IL-18, and monocyte chemoattractant protein-1 (MCP-1). Data were analyzed using multiple linear regression models. Total and bouts of ≥10 min of sedentary time were inversely associated with the anti-inflammatory marker IL-10 in older men (accumulated sedentary time: β = −0.116; bouts: β = −0.099; all p < 0.05). Associations were independent of moderate-to-vigorous physical activity (MVPA) and total PA volume. In women, total and bouts of ≥10 min of sedentary time were detrimentally associated with the pro-inflammatory marker fibrinogen (accumulated sedentary time: β = −0.130; bouts: β = −0.085; all p < 0.05). Associations remained between accumulated sedentary time and fibrinogen when adjusting for MVPA and total PA volume. This study highlights sex-specific routes by which sedentary patterns impact on pro- and anti-inflammatory biomarkers in older adults. The findings support efforts to promote accumulation of time spent in PA at the expense of time in sedentary pursuits on low-grade inflammation in older men and women.

ACS Style

Oscar Bergens; Andreas Nilsson; Konstantinos-Georgios Papaioannou; Fawzi Kadi. Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults. Frontiers in Physiology 2021, 12, 1 .

AMA Style

Oscar Bergens, Andreas Nilsson, Konstantinos-Georgios Papaioannou, Fawzi Kadi. Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults. Frontiers in Physiology. 2021; 12 ():1.

Chicago/Turabian Style

Oscar Bergens; Andreas Nilsson; Konstantinos-Georgios Papaioannou; Fawzi Kadi. 2021. "Sedentary Patterns and Systemic Inflammation: Sex-Specific Links in Older Adults." Frontiers in Physiology 12, no. : 1.

Journal article
Published: 27 June 2019 in Military Medicine
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Introduction Strength training has been routinely used in exercise programs of military groups; however, no review has been ever conducted to clarify the selection of exercise tests to monitor its effectiveness. Therefore, the aim of the present review was to critically evaluate the current practices in the choice of assessment methods for muscle strength in military and suggest directions for future research. Methods The Scopus and Pubmed databases were searched in December 2018 using “fitness assessment OR muscle strength AND military OR army” as keywords. Results Methodological concerns were highlighted in exercise testing of muscle strength, where the use of appropriate tests were recommended (handgrip, isokinetic or 1RM in bench or leg press) to complement tests that measured muscle endurance rather than muscle strength (e.g., timed push-ups or sit-ups). Conclusions Although strength training has been included in military training, it was concluded that the existed physical fitness test batteries focused mostly on muscle endurance rather than on muscle strength. Therefore, it would be suggested that muscle strength tests be included in future physical fitness test batteries in order to evaluate effectively the content of military training.

ACS Style

Pantelis T Nikolaidis; Konstantinos-Georgios Papaioannou; Thomas Rosemann; Beat Knechtle. Exercise Testing of Muscle Strength in Military. Military Medicine 2019, 184, e426 -e430.

AMA Style

Pantelis T Nikolaidis, Konstantinos-Georgios Papaioannou, Thomas Rosemann, Beat Knechtle. Exercise Testing of Muscle Strength in Military. Military Medicine. 2019; 184 (9-10):e426-e430.

Chicago/Turabian Style

Pantelis T Nikolaidis; Konstantinos-Georgios Papaioannou; Thomas Rosemann; Beat Knechtle. 2019. "Exercise Testing of Muscle Strength in Military." Military Medicine 184, no. 9-10: e426-e430.

Journal article
Published: 01 October 2016 in Free Radical Biology and Medicine
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ACS Style

Juha J. Hulmi; Jaakko Hentilä; Keith C. DeRuisseau; Bernardo M. Oliveira; Konstantinos G. Papaioannou; Reija Autio; Urho M. Kujala; Olli Ritvos; Heikki Kainulainen; Ayhan Korkmaz; Mustafa Atalay. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radical Biology and Medicine 2016, 99, 308 -322.

AMA Style

Juha J. Hulmi, Jaakko Hentilä, Keith C. DeRuisseau, Bernardo M. Oliveira, Konstantinos G. Papaioannou, Reija Autio, Urho M. Kujala, Olli Ritvos, Heikki Kainulainen, Ayhan Korkmaz, Mustafa Atalay. Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress. Free Radical Biology and Medicine. 2016; 99 ():308-322.

Chicago/Turabian Style

Juha J. Hulmi; Jaakko Hentilä; Keith C. DeRuisseau; Bernardo M. Oliveira; Konstantinos G. Papaioannou; Reija Autio; Urho M. Kujala; Olli Ritvos; Heikki Kainulainen; Ayhan Korkmaz; Mustafa Atalay. 2016. "Effects of muscular dystrophy, exercise and blocking activin receptor IIB ligands on the unfolded protein response and oxidative stress." Free Radical Biology and Medicine 99, no. : 308-322.

Comment
Published: 14 September 2016 in The Journal of Physiology
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ACS Style

Raffaele Mazzolari; Konstantinos-Georgios Papaioannou. Satellite cells: erythropoietin treatment and endurance training. The Journal of Physiology 2016, 594, 5045 -5046.

AMA Style

Raffaele Mazzolari, Konstantinos-Georgios Papaioannou. Satellite cells: erythropoietin treatment and endurance training. The Journal of Physiology. 2016; 594 (18):5045-5046.

Chicago/Turabian Style

Raffaele Mazzolari; Konstantinos-Georgios Papaioannou. 2016. "Satellite cells: erythropoietin treatment and endurance training." The Journal of Physiology 594, no. 18: 5045-5046.

Journal article
Published: 05 February 2016 in Biomarkers
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Postexercise urine lactate may be a novel biomarker of lactate production capacity during exercise.

ACS Style

Stefanos Nikolaidis; Christina Karpouzi; George Tsalis; Athanasios Kabasakalis; Konstantinos G. Papaioannou; Vassilis Mougios. Reliability of urine lactate as a novel biomarker of lactate production capacity in maximal swimming. Biomarkers 2016, 21, 328 -334.

AMA Style

Stefanos Nikolaidis, Christina Karpouzi, George Tsalis, Athanasios Kabasakalis, Konstantinos G. Papaioannou, Vassilis Mougios. Reliability of urine lactate as a novel biomarker of lactate production capacity in maximal swimming. Biomarkers. 2016; 21 (4):328-334.

Chicago/Turabian Style

Stefanos Nikolaidis; Christina Karpouzi; George Tsalis; Athanasios Kabasakalis; Konstantinos G. Papaioannou; Vassilis Mougios. 2016. "Reliability of urine lactate as a novel biomarker of lactate production capacity in maximal swimming." Biomarkers 21, no. 4: 328-334.

Research article
Published: 12 October 2015 in Journal of Proteome Research
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The delineation of exercise biochemistry by utilizing metabolic fingerprinting has become an established strategy. We present a combined RP-UPLC-MS and 1H NMR strategy, supplemented by photometric assays, to monitor the response of the human urinary metabolome to short maximal exercise. Seventeen male volunteers performed two identical sprint sessions on separate days, consisting of three 80 m maximal runs. Using univariate and multivariate analyses, we followed the fluctuation of 37 metabolites at 1, 1.5, and 2 h postexercise. 2-Hydroxyisovalerate, 2-hydroxybutyrate, 2-oxoisocaproate, 3-methyl-2-oxovalerate, 3-hydroxyisobutyrate, 2-oxoisovalerate, 3-hydroxybutyrate, 2-hydroxyisobutyrate, alanine, pyruvate, and fumarate increased 1 h postexercise and then returned toward baseline. Lactate and acetate were higher than baseline at 1 and 1.5 h. Hypoxanthine and inosine remained above baseline throughout the postexercise period. Urate decreased at 1 h and increased at 1.5 h before returning to baseline. Valine, isoleucine, succinate, citrate, trimethylamine, trimethylamine N-oxide, tyrosine, and formate decreased at 1 h and/or 1.5 h postexercise and then returned to baseline. Creatinine gradually decreased over the sampling period. Glycine, 4-aminohippurate, and hippurate remained below baseline throughout the postexercise period. Our findings show that even one-half minute of maximal exercise elicited major perturbations in human metabolism, several of which persisted for at least 2 h.

ACS Style

Alexandros Pechlivanis; Konstantinos G. Papaioannou; George Tsalis; Ploutarchos Saraslanidis; Vassilis Mougios; Georgios A. Theodoridis. Monitoring the Response of the Human Urinary Metabolome to Brief Maximal Exercise by a Combination of RP-UPLC-MS and 1H NMR Spectroscopy. Journal of Proteome Research 2015, 14, 4610 -4622.

AMA Style

Alexandros Pechlivanis, Konstantinos G. Papaioannou, George Tsalis, Ploutarchos Saraslanidis, Vassilis Mougios, Georgios A. Theodoridis. Monitoring the Response of the Human Urinary Metabolome to Brief Maximal Exercise by a Combination of RP-UPLC-MS and 1H NMR Spectroscopy. Journal of Proteome Research. 2015; 14 (11):4610-4622.

Chicago/Turabian Style

Alexandros Pechlivanis; Konstantinos G. Papaioannou; George Tsalis; Ploutarchos Saraslanidis; Vassilis Mougios; Georgios A. Theodoridis. 2015. "Monitoring the Response of the Human Urinary Metabolome to Brief Maximal Exercise by a Combination of RP-UPLC-MS and 1H NMR Spectroscopy." Journal of Proteome Research 14, no. 11: 4610-4622.

Journal article
Published: 01 January 2015 in Molecular and Cellular Endocrinology
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Duchenne muscular dystrophy is characterized by muscle wasting and decreased aerobic metabolism. Exercise and blocking of myostatin/activin signaling may independently or combined counteract muscle wasting and dystrophies. The effects of myostatin/activin blocking using soluble activin receptor-Fc (sActRIIB-Fc) administration and wheel running were tested alone or in combination for 7 weeks in dystrophic mdx mice. Expression microarray analysis revealed decreased aerobic metabolism in the gastrocnemius muscle of mdx mice compared to healthy mice. This was not due to reduced home-cage physical activity, and was further downregulated upon sActRIIB-Fc treatment in enlarged muscles. However, exercise activated pathways of aerobic metabolism and counteracted the negative effects of sActRIIB-Fc. Exercise and sActRIIB-Fc synergistically increased expression of major urinary protein, but exercise blocked sActRIIB-Fc induced phosphorylation of STAT5 in gastrocnemius muscle. In conclusion, exercise alone or in combination with myostatin/activin blocking corrects aerobic gene expression profiles of dystrophic muscle toward healthy wild type mice profiles.

ACS Style

Heikki Kainulainen; Konstantinos G. Papaioannou; Mika Silvennoinen; Reija Autio; Janne Saarela; Bernardo M. Oliveira; Miro Nyqvist; Arja Pasternack; Peter A.C. 't Hoen; Urho M. Kujala; Olli Ritvos; Juha J. Hulmi. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology 2015, 399, 131 -142.

AMA Style

Heikki Kainulainen, Konstantinos G. Papaioannou, Mika Silvennoinen, Reija Autio, Janne Saarela, Bernardo M. Oliveira, Miro Nyqvist, Arja Pasternack, Peter A.C. 't Hoen, Urho M. Kujala, Olli Ritvos, Juha J. Hulmi. Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice. Molecular and Cellular Endocrinology. 2015; 399 ():131-142.

Chicago/Turabian Style

Heikki Kainulainen; Konstantinos G. Papaioannou; Mika Silvennoinen; Reija Autio; Janne Saarela; Bernardo M. Oliveira; Miro Nyqvist; Arja Pasternack; Peter A.C. 't Hoen; Urho M. Kujala; Olli Ritvos; Juha J. Hulmi. 2015. "Myostatin/activin blocking combined with exercise reconditions skeletal muscle expression profile of mdx mice." Molecular and Cellular Endocrinology 399, no. : 131-142.