Peripheral ossifying fibroma (POF) is a benign localized lesion originating from gingival and alveolar oral mucosa. Its origin can be cells of periodontal ligament. The lesions usually develop in women in their twenties. POF is a complex clinical and histological diagnosis due to its shared characteristics with many other conditions. In this paper, we presented a case of an atypical peripheral ossifying fibroma (POF) in the left lateral part of the mandible in a 70-year-old male patient who had two semicircular bridges supported on four implants in the upper and lower jaws. A review of CBCT and orthopedic imaging showed no visible intraosseous changes. Histological analysis revealed the diagnosis of POF. The case in question is interesting, as elaborated on in the discussion section of this paper because POF is usually found in female patients aged between 20 and 30 years.

Background/Objectives: Precise implant positioning is critical for successful prosthetic rehabilitation, particularly in completely edentulous patients where anatomical landmarks are lost. The aim of this study was to assess the accuracy of implant placement in the edentulous maxilla and mandible using computer-assisted planning and a bone-supported stackable surgical guide protocol. Methods: This retrospective clinical study included 15 completely edentulous patients who received a total of 60 implants. A dual-scan protocol was utilized for planning. The surgical protocol involved a base guide fixed to the bone with pins, serving as a rigid foundation for stackable components used for osteotomy and implant insertion. Postoperative CBCT scans were superimposed onto the preoperative plan to calculate angular deviations, 3D linear deviations at the implant neck and apex, and depth deviations. Results: The analysis demonstrated high accuracy with a mean angular deviation of 1.25° ± 0.80°. The mean 3D linear deviation was 0.96 ± 0.57 mm at the implant neck and 1.07 ± 0.56 mm at the apex. Depth deviation showed a mean discrepancy of 0.37 ± 0.58 mm. All measured parameters were statistically significantly lower (p < 0.05) than the pre-established clinical safety thresholds. Conclusions: Within the limitations of this study, the bone-supported stackable surgical guide protocol proved to be a highly accurate method for full-arch rehabilitation. By eliminating mucosal resilience and ensuring rigid fixation, this approach enables predictable implant placement and facilitates the passive fit of screw-retained bar-supported prostheses, representing a reliable alternative to dynamic navigation in daily clinical practice.

Background: Recent advances in mRNA vaccine technology, accelerated by the global COVID-19 pandemic, have generated significant interest in their applications beyond infectious diseases. Dentistry has emerged as a promising field for exploring the potential of mRNA-based therapies in preventing and treating oral diseases. Objectives: This narrative review aims to evaluate the current status of mRNA vaccine development and its preclinical applications in oral health, focusing on periodontal disease, dental caries, regenerative medicine, implantology, and oral cancer. Methods: The review synthesizes findings from preclinical studies, including research conducted in animal models and in vitro, to assess the potential of mRNA-based therapies to modulate immune responses and promote tissue regeneration in the oral cavity. Clinical trials were only mentioned in the context of broader areas of mRNA vaccine implementation such as oncology and immunotherapy. Results: The preclinical studies highlight the capacity of mRNA vaccines to enhance the body’s immune response and facilitate tissue repair processes. Despite these promising results, challenges persist in delivering mRNA vaccines effectively within the complex oral environment. These challenges include vaccine stability, delivery mechanisms, and the modulation of immune responses. Conclusions: While mRNA vaccines offer significant promise for revolutionizing oral health care, they face notable limitations concerning safety, efficacy, and clinical feasibility. Overcoming these obstacles through further research is essential to unlock their full translational potential and ensure their safe and effective integration into dental practice.

Statins, a class of cholesterol-loweringdrugs, have been investigated for their potential benefits in oral surgery, particularly in bone osteotomy and augmentation procedures. Recent studies suggest that statins may stimulate bone formation and enhance the osseointegration of dental implants. This review examines the current evidence on the effects of statins on bone osteotomy and augmentation in oral surgery. The available data indicates that while patients with a history of bisphosphonate use may not face a higher risk of dental implant failure or marginal bone loss, they may be more susceptible to bisphosphonate-related osteonecrosis of the jaw. Further research is needed to fully elucidate the impact of antiresorptive drugs, including statins, on dental implant outcomes and to identify optimal strategies for managing patients undergoing oral surgical procedures. The practice of fixed bridges and partial prosthesis can be and are iatrogenic to the existing teeth and bone. Dental implants have become a viable treatment option when there is sufficient quantity and quality of bone to achieve the desired functional and esthetic results. Horizontal ridge augmentation and contextual implant placement with a resorbable membrane and particulate grafting material can be used to reconstruct three-dimensional atrophic edentulous areas of the jaws, allowing for correct implant positioning and avoiding mechanical and prosthetic failures. The reduction in bone volume has many etiologies, including periodontal disease, pneumatization of the maxillary sinus, long-term ill-fitting dentures, and the general progression of osteoporosis with aging. Interestingly, recent studies suggest that statins, a class of cholesterol-lowering drugs, may have a positive effect on bone osteotomy and augmentation in oral surgery. Statins have been found to stimulate bone formation and enhance the osseointegration of dental implants.

Statins are one of the most commonly used drugs for the prevention of atherosclerosis and ischemic heart disease. Statins have an antibacterial effect against oral pathogens, especially against Aggregatibacter actinomycetemcomitans and Porphyromonas gingivalis. Studies on animals that we analyzed in this chapter show that statins promote angiogenesis and osteoblast differentiation. Data on the effect of statins on the process of osseointegration are important in clinical practice and should be an integral part of dental education. PubMed, Cochrane Central, and Web of Science database search was performed for animal studies on statin effects on dental osseointegration. Fifteen studies performed on laboratory animals were identified where statins were applied systemically, locally, orally, subcutaneously, or intraosseously. Titan implants of different diameters were placed in tibia and femur of animals. Statins improved osseointegration and enhanced contact of implant surface with the newly formed bone, as well as significantly increased the volume of newly formed bone in lab animals. The purpose of this chapter is to prove the relationship between local use of statins and better osseointegration, as well as a larger amount of newly formed bone around the implant. Knowledge of the effect of frequently prescribed medications on dental procedures and osseointegration is necessary for both students and physicians.