Ahmed Al-Abd

Dr. Ahmed Al-Abd

orcid

Research Focus & Metrics

Academic Career Length

20Years (2007-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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8 February 2021 in Autophagy
Verified
Journal Article
Closed access
DKDaniel J. Klionsky
Daniel J. Klionsky
AAAmal Kamal Abdel-Aziz
Amal Kamal Abdel-Aziz
SASara Abdelfatah
Sara Abdelfatah
MAMahmoud Abdellatif
Mahmoud Abdellatif
AAAsghar Abdoli
Asghar Abdoli
CTChun-Kit Tong
Chun-Kit Tong

1 January 2016 in Drug Design, Development and Therapy
Verified
Journal Article
Open access
PDF file
AAAhmed Al-Abd
Ahmed Al-Abd
BABader M Aljaeid
Bader M Aljaeid
Naturally occurring polymers, particularly of the polysaccharide type, have been used pharmaceutically for the delivery of a wide variety of therapeutic agents. Chitosan, the second abundant naturally occurring polysaccharide next to cellulose, is a biocompatible and biodegradable mucoadhesive polymer that has been extensively used in the preparation of micro- as well as nanoparticles. The prepared particles have been exploited as a potential carrier for different therapeutic agents such as peptides, proteins, vaccines, DNA, and drugs for parenteral and nonparenteral administration. Therapeutic agent-loaded chitosan micro- or nanoparticles were found to be more stable, permeable, and bioactive. In this review, we are highlighting the different methods of preparation and characterization of chitosan micro- and nanoparticles, while reviewing the pharmaceutical applications of these particles in drug delivery. Moreover, the roles of chitosan derivatives and chitosan metal nanoparticles in drug delivery have been illustrated.

17 October 2018 in ACS Nano
Verified
Journal Article
Closed access
HEHossam Samir El-Sawy
Hossam Samir El-Sawy
AAAhmed Al-Abd
Ahmed Al-Abd
AAAhmed Al-Abd
Ahmed Al-Abd
Khalid M El-SayKhalid M El-Say
Khalid M El-Say
VTVladimir P. Torchilin
Vladimir P. Torchilin

1 January 2015 in Journal of Advanced Research
Verified
Journal Article
Open access
Hossam AbdallahHossam Abdallah
Hossam Abdallah
AAAhmed Al-Abd
Ahmed Al-Abd
RERiham Salah El-Dine
Riham Salah El-Dine
AHAli El Halawany
Ali El Halawany
Resistance of solid tumors to treatment is significantly attributed to pharmacokinetic reasons at both cellular and multi-cellular levels. Anticancer agent must be bio-available at the site of action in a cytotoxic concentration to exert its proposed activity. P-glycoprotein (P-gp) is a member of the ATP-dependent membrane transport proteins; it is known to pump substrates out of cells in ATP-dependent mechanism. The over-expression of P-gp in tumor cells reduces the intracellular drug concentrations, which decreases the cytotoxicity of a broad spectrum of antitumor drugs. Accordingly, P-gp inhibitors/blockers are potential enhancer for the cellular bioavailability of several clinically important anticancer drugs such as, anthracyclines, taxanes, vinca alkaloids, and podophyllotoxins. Besides several chemically synthesized P-gp inhibitors/blockers, some naturally occurring compounds and plant extracts were reported for their modulation of multidrug resistance; however, this review will focus only on major classes of naturally occurring inhibitors viz., flavonoids, coumarins, terpenoids, alkaloids and saponins.

1 August 2017 in Materials Science and Engineering: C
Verified
Journal Article
Closed access
ZHZahid Hussain
Zahid Hussain
HTHnin Ei Thu
Hnin Ei Thu
MAMuhammad Wahab Amjad
Muhammad Wahab Amjad
FHFahad Hussain
Fahad Hussain
AAAhmed Al-Abd
Ahmed Al-Abd
SKShahzeb Khan
Shahzeb Khan

1 July 2018 in Toxicology Letters
Verified
Journal Article
Closed access
RARasha M. Allam
Rasha M. Allam
AAAhmed Al-Abd
Ahmed Al-Abd
AKAlaa M Khedr
Alaa M Khedr
OSOla A. Sharaf
Ola A. Sharaf
SNSalwa M. Nofal
Salwa M. Nofal
AAAshraf B. Abdel-Naim
Ashraf B. Abdel-Naim