The COVID-19 pandemic has imposed a wide variety of unprecedented challenges, many of which appear to be disproportionately affecting the mental health and well-being of young adults. While there is evidence to suggest university students experience high rates of mental health disorders, less is known about the specific impacts of the COVID-19 pandemic on student mental health and how they are coping with this stress. To address this gap, we conducted an online study among undergraduate students (n = 366) to examine the impact of the COVID-19 pandemic on academics, social isolation, and mental health, as well as the extent to which they have been implementing a variety of coping strategies. The pandemic had a more pronounced negative effect on female students' academics, social isolation, stress and mental health compared to male counterparts. Moreover, for females, frequent use of social media as a coping mechanism was associated with greater perceived negative impacts on their academic performance and stress levels, compared to males. However, frequent social media use related to similar negative mental health effects for both males and females. While male and female students both reported using substances to cope, for males the use of cannabis was associated with greater negative impacts on academic outcomes, stress and mental health compared to females. These findings highlight the need for adequate student support services across the post-secondary sector, and point to the importance of gender informed interventions to address the impacts of the COVID-19 pandemic.

Considering the burden of depression and the lack of efficacy of available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable biomarkers for depression has been challenging, likely owing to the vast symptom heterogeneity and high rates of comorbidity that exists. Examining biomarkers that map onto dimensions of depression as well as shared symptoms/constructs that cut across disorders could be most effective for informing personalized treatment approaches. With a sample of 539 young adults, we conducted a principal component analysis (PCA) followed by hierarchical cluster analysis to develop transdiagnostic clusters of depression and anxiety symptoms. We collected blood to assess whether neuroendocrine (cortisol) and inflammatory profiles (C-reactive protein (CRP), Interleukin (IL)-6, and tumor necrosis factor (TNF) – α) could be used to differentiate symptom clusters. Six distinct clusters were identified that differed significantly on symptom dimensions including somatic anxiety, general anxiety, anhedonia, and neurovegetative depression. Moreover, the neurovegetative depression cluster displayed significantly elevated CRP levels compared to other clusters. In fact, inflammation was not strongly associated with overall depression scores or severity, but rather related to specific features of depression marked by eating, appetite, and tiredness. This study emphasizes the importance of characterizing the biological underpinnings of symptom dimensions and subtypes to better understand the etiology of complex mental health disorders such as depression.

First Nations children are over 17 times more likely to be removed from their families and placed in the child welfare system (CWS) than non-Indigenous children in Canada. The high rates of parent-child separation have been linked to discriminatory public services and the Indian Residential School (IRS) system, which instigated a multi-generational cycle of family disruption. However, limited empirical evidence exists linking the IRS to subsequent parent-child separations, the CWS, and mental health outcomes among First Nations, Inuit, and Métis populations in Canada. The current studies examine these relationships using a nationally representative sample of First Nations youth (ages 12–17 years) living in communities across Canada (Study 1), and among First Nations and Métis adults (ages 18+ years) in Canada (Study 2). Study 1 revealed that First Nations youth with a parent who attended IRS had increased odds of not living with either of their biological parents, and both IRS and not living with biological parents independently predicted greater psychological distress. Similarly, Study 2 revealed that First Nations and Métis adults with familial IRS history displayed greater odds of spending time in the CWS, and both IRS and CWS predicted elevated depressive symptoms. The increased distress and depressive symptoms associated with parent-child separations calls for First Nations-led interventions to address the inequities in the practices of removing Indigenous children and youth from their families.

Although the neuropeptide oxytocin has been associated with enhanced prosocial behaviors, it has also been linked to aggression and mental health disorders. Thus, it was suggested that oxytocin might act by increasing the salience of social stimuli, irrespective of whether these are positive or negative, thus increasing vulnerability to negative mental health outcomes. The current study (N = 243), conducted among White university students, examined the relation of trauma, depressive symptoms including suicidal ideation in relation to a single nucleotide polymorphism (SNP) within the oxytocin receptor gene (OXTR), rs53576, and a SNP on the CD38 gene that controls oxytocin release, rs3796863. Individuals with the polymorphism on both alleles (AA genotype) of the CD38 SNP had previously been linked to elevated plasma oxytocin levels. Consistent with the social sensitivity perspective, however, in the current study, individuals carrying the AA genotype displayed elevated feelings of alienation from parents and peers as well as increased levels of suicidal ideation. Moreover, they tended to report elevated depressive symptoms compared to CC homozygotes. It was also observed that the CD38 genotype moderated the relation between trauma and suicidal ideation scores, such that high levels of trauma were associated with elevated suicidal ideation among all CD38 genotypes, but this relationship was stronger among individuals with the AA genotype. In contrast, there was no relationship between the OXTR SNP, rs53576, depression or suicidal ideation. These findings support a social sensitivity hypothesis of oxytocin, wherein the AA genotype of the CD38 SNP, which has been considered the ‘protective allele’ was associated with increased sensitivity and susceptibility to disturbed social relations and suicidal ideation.

Depression is a multifaceted disorder characterized by heterogeneous symptom profiles and high rates of comorbidity with other commonly occurring mental illnesses. Considering the burden of mental health disorders and the lack of efficacy of available treatments, there is a need for biomarkers to predict tailored or personalized treatments. However, identifying reliable biomarkers for complex mental illnesses, such as depression, anxiety and PTSD, has been challenging, likely owing to the heterogeneity, comorbidity and differences in experiences and histories of individuals. For these reasons, taking a transdiagnostic approach, which identifies biomarkers that map onto shared symptoms/constructs across disorders could be most effective for informing personalized or precision medicine approaches in psychiatry. Transdiagnostic features of anxiety, depression and anhedonia have been examined in relation to brain activity and connectivity patterns. Neuroendocrine and inflammatory markers, which are altered in depression and other comorbid illness, such as post-traumatic stress disorder (PTSD), might be useful in differentiating transdiagnostic symptom profiles as well as treatment responses. Ultimately, biomarker research that looks beyond diagnostic categories and embraces the complexity of individuals' lives and experiences might be more effective in moving towards precision medicine in psychiatry.

As nonmedical cannabis is now legal in Canada, it is important to understand the complex relationship between perceptions of risk, problematic cannabis use and mental health among young adults. Objectives: To assess whether perceptions of risk associated with cannabis relates to cannabis use among young adults. Moreover, we explored whether current symptoms of anxiety were also related to problematic use, and the role of gender in this relationship. Methods: Self-report surveys were completed by 1043 Carleton University students. Students completed several questionnaires assessing perceptions of risk associated with cannabis use, and cannabis use and anxiety symptoms. Results: Males were significantly more likely to rate some of the harms associated with cannabis use as less risky, and reported higher rates of cannabis use. We also found that problematic cannabis use was positively related to anxiety symptoms, and this relationship was moderated by gender such that greater cannabis use related to higher anxiety scores more strongly among females. Conclusions: Our study yields valuable information regarding how Canadian youth perceive the risks associated with cannabis use; critically, males are more likely to perceive minimal risk with use and are also more likely to use problematically. By contrast, cannabis use is more strongly related to anxiety among females. These results have important implications for education and outreach campaigns associated with the legalization of cannabis and cannabis products in Canada. Comme le cannabis non médical est maintenant légal au Canada, il est important de comprendre la relation complexe entre les perceptions du risque, la consommation problématique de cannabis et la santé mentale des jeunes adultes. Objectifs: Évaluer si les perceptions de risque associé au cannabis sont liées à la consommation de cannabis chez les jeunes adultes. De plus, nous avons examiné si les symptômes d’anxiété actuels étaient également liés à une utilisation problématique et le rôle du genre dans cette relation. Méthodes: Des sondages d’auto-évaluation ont été effectués par 1 043 étudiants de l’Université de Carleton. Les élèves ont rempli plusieurs questionnaires évaluant les perceptions du risque associé à la consommation de cannabis, à la consommation de cannabis et aux symptômes d’anxiété. Résultats: Les hommes étaient beaucoup plus susceptibles de juger certains risques liés à la consommation de cannabis comme moins dangereux et ont signalé des taux de consommation de cannabis plus élevés. Nous avons également constaté que la consommation problématique de cannabis était positivement liée aux symptômes d’anxiété, cette relation étant modérée en fonction du sexe, de sorte qu’une plus grande consommation de cannabis était associée à des scores d’anxiété plus élevés chez les femmes. Conclusions: Notre étude fournit des informations précieuses sur la manière dont les jeunes Canadiens perçoivent les risques associés à la consommation de cannabis. De manière critique, les hommes sont plus susceptibles de percevoir un risque minimal avec l’utilisation et sont également plus susceptibles de l’utiliser de manière problématique. En revanche, la consommation de cannabis est davantage liée à l’anxiété chez les femmes. Ces résultats ont des implications importantes pour les campagnes d’éducation et de sensibilisation associées à la légalisation du cannabis et des produits à base de cannabis au Canada.