A highly sensitive and precise Love wave mode surface acoustic wave (SAW) immunosensor based on an ST-cut 90°X quartz substrate and an SiO₂ wave-guiding layer was developed to detect cancer-related biomarkers of carcinoembryonic antigens (CEAs). A delay line structure of the SAW device with a resonant frequency of 196 MHz was designed/fabricated, and its surface was functionalized through CEA antibody immobilization. The CEA antibodies were bound with gold nanoparticles and CEA antibodies to form a sandwich structure, which significantly amplified the mass loading effect and enhanced the maximum responses by 30 times. The center frequency of the Love wave immunosensor showed a linear response as a function of the CEA concentration in the range of 0.2–5 ng/mL. It showed a limit of detection of 0.2 ng/mL, and its coefficient of determination was 0.983. The sensor also showed minimal interference from nonspecific adsorptions, thus demonstrating its promise for point-of-care applications for cancer biomarkers.

We propose an ultrasensitive leaky surface acoustic wave (LSAW) immunosensor based on molybdenum disulfide @ cuprous oxide—gold (MoS₂@Cu₂O-Au) nanoparticles and subsequent gold staining for the detection of alpha-fetoprotein (AFP). MoS₂@Cu₂O-Au nanoparticles, with their large specific surface area and good biocompatibility, not only capture the secondary antibodies (Ab₂) but also amplify the mass loading effect of the acoustic wave sensor in the detection of AFP. The immunosensor signals are further amplified upon injection of gold staining solution. The developed immunosensor achieved a low detection limit of 5.5 and 25.0 pg/mL with and without gold staining, respectively. The immunosensor demonstrated its efficiency for the quantitative detection of AFP in complex biological fluids, including human serum and saliva samples, with excellent selectivity and long-term stability, showing great potential for the quantification of AFP in clinical diagnosis.

Surface acoustic wave (SAW) devices are one of the indispensable components in the radio frequency (RF) front-end of mobile phones. With the development of mobile communication technology, the requirements for linear specification of devices are more and more strict. Nonlinear distortions of SAW devices have a serious influence on the application of mobile RF modules. To satisfy the strict requirement of linearity of communication system, it is necessary to understand the generation mechanism of nonlinearity and study the accurate modeling, appropriate measurement methods, and nonlinear response elimination technology. In this paper, we summarize the research progress on the nonlinearity of SAW devices in recent years from four aspects: the generation mechanism, simulation methods, measurement system, and suppression technology. The nonlinear harmonics with the nonlinear Mason equivalent circuit model are simulated. Furthermore, harmonics and intermodulation signals of SAW filters are tested by the authors. Thanks to these research studies, it is of great significance to the development of future RF front-end modules with high linear SAW devices.

Nitrogen dioxide is one origin of air pollution from fossil fuels with the potential to cause great harm to human health in low concentrations. Therefore, low-cost, low-power-consumption sensors for low-concentration NO₂ detection are essential. Herein, heterojunction by SnO₂ quantum wires, a traditional metal oxide NO₂ sensing material, and Ti₃C₂T_x MXene, a novel type of 2D layered material, was synthesized using a simple solvothermal method for enhancing gas-sensing performance and reducing operating temperature. The operating temperature was reduced to 80 °C, with a best performance of 27.8 and a fast response and recovery time (11 s and 23 s, respectively). The SnO₂ and Ti₃C₂T_x MXene composite exhibits high speed and low detection limit due to the construction of the heterojunction with high conductive Ti₃C₂T_x MXene. The selectivity and stability of gas sensors are carried out. This could enable the realization of fast response, high-sensitivity, and selective NO₂ sensing under low operating temperatures.

Surface acoustic wave (SAW) sensors have been applied in various areas with many advantages, such as their small size, high sensitivity and wireless and passive form. Love wave mode sensors, an important kind of SAW sensor, are mostly used in biology and chemistry monitoring, as they can be used in a liquid environment. Common Love wave mode sensors consist of a delay line with waveguide and sensitive layers. To extend the application of Love wave mode sensors, this article reports a novel Love wave mode sensor consisting of a waveguide layer with microphononic crystals (PnCs). To analyze the properties of the new structure, the band structure was calculated, and transmission was obtained by introducing delay line structures and quasi-three-dimensional models. Furthermore, devices with a traditional structure and novel structure were fabricated. The results show that, by introducing the designed microstructure of phononic crystals in the waveguide layer, the attenuation was barely increased, and the frequency was shifted by a small amount. In the liquid environmental experiments, the novel structure with micro PnCs shows even better character than the traditional one. Moreover, the introduced microstructure can be extended to microreaction tanks for microcontrol. Therefore, this novel Love wave mode sensor is a promising application for combining acoustic sensors and microfluidics.