Alexandre Legros

Dr. Alexandre Legros


Research Focus & Metrics

Academic Career Length

24Years (2003-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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22 November 2019 in IEEE Access
Verified
Journal Article
Open access
WBWilliam H. Bailey
William H. Bailey
THTim Harrington
Tim Harrington
AHAkimasa Hirata
Akimasa Hirata
RKRobert Rob Kavet
Robert Rob Kavet
JKJafar Keshvari
Jafar Keshvari
KGKevin Graf
Kevin Graf
The newly released IEEE Std C95.1™-2019 defines exposure criteria and associated limits for the protection of persons against established adverse health effects from exposures to electric, magnetic, and electromagnetic fields, in the frequency range 0 Hz to 300 GHz. The exposure limits apply to persons permitted in restricted environments and to the general public in unrestricted environments. These limits are not intended to apply to the exposure of patients by or under the direction of physicians and care professionals, as well as to the exposure of informed volunteers in scientific research studies, or to the use of medical devices or implants. IEEE Std C95.1™-2019 can be obtained at no cost from the IEEE Get Program https://ieeexplore.ieee.org/document/8859679 .

1 March 2003 in Journal of Motor Behavior
Verified
Journal Article
Closed access
DDDidier Delignlères
Didier Delignlères
TDThibault Deschamps
Thibault Deschamps
ALAlexandre Legros
Alexandre Legros
NCNicolas Caillou
Nicolas Caillou
The authors reexamined, theoretically and empirically, the method proposed by J. J. Collins and C. D. De Luca (1993) for the analysis of center-of-pressure trajectories. The main argument in this article is that Collins and De Luca's approach is not adapted to the analysis of bounded time series and leads to statistical artifacts such as underestimation of the diffusion process for long-term intervals. The open- and closed-loop model developed by Collins and De Luca is a direct consequence of those statistical problems. Applying more classical methods, such as rescaled range analysis or detrended fluctuation analysis, the authors show that center-of-pressure trajectories can be modeled as continuous, antipersistent fractional Brownian motion. More specifically, those trajectories behave like 1/f noise, a ubiquitous feature in adaptive biological systems.

17 February 2009 in International Archives of Occupational and Environmental Health
Verified
Journal Article
Closed access
PDF file
DMDavid Andrew McNamee
David Andrew McNamee
ALAlexandre Legros
Alexandre Legros
DKDaniel R. Krewski
Daniel R. Krewski
GWGerald Wisenberg
Gerald Wisenberg
FPFrank Prato
Frank Prato
ATAlex W. Thomas
Alex W. Thomas

17 November 2010 in Interface Focus
Verified
Journal Article
Closed access
JMJulien Modolo
Julien Modolo
ALAlexandre Legros
Alexandre Legros
ATAlex W. Thomas
Alex W. Thomas
ABAnne Beuter
Anne Beuter
Electric stimulation has been investigated for several decades to treat, with various degrees of success, a broad spectrum of neurological disorders. Historically, the development of these methods has been largely empirical but has led to a remarkably efficient, yet invasive treatment: deep brain stimulation (DBS). However, the efficiency of DBS is limited by our lack of understanding of the underlying physiological mechanisms and by the complex relationship existing between brain processing and behaviour. Biophysical modelling of brain activity, describing multi-scale spatio-temporal patterns of neuronal activity using a mathematical model and taking into account the physical properties of brain tissue, represents one way to fill this gap. In this review, we illustrate how biophysical modelling is beginning to emerge as a driving force orienting the development of innovative brain stimulation methods that may move DBS forward. We present examples of modelling works that have provided fruitful insights in regards to DBS underlying mechanisms, and others that also suggest potential improvements for this neurosurgical procedure. The reviewed literature emphasizes that biophysical modelling is a valuable tool to assist a rational development of electrical and/or magnetic brain stimulation methods tailored to both the disease and the patient's characteristics.


27 July 2015 in PLOS ONE
Verified
Journal Article
Open access
PDF file
ALAlexandre Legros
Alexandre Legros
JMJulien Modolo
Julien Modolo
SBSamantha Brown
Samantha Brown
JRJohn Roberston
John Roberston
ATAlex W. Thomas
Alex W. Thomas
Several aspects of the human nervous system and associated motor and cognitive processes have been reported to be modulated by extremely low-frequency (ELF, < 300 Hz) time-varying Magnetic Fields (MF). Due do their worldwide prevalence; power-line frequencies (60 Hz in North America) are of particular interest. Despite intense research efforts over the last few decades, the potential effects of 60 Hz MF still need to be elucidated, and the underlying mechanisms to be understood. In this study, we have used functional Magnetic Resonance Imaging (fMRI) to characterize potential changes in functional brain activation following human exposure to a 60 Hz MF through motor and cognitive tasks. First, pilot results acquired in a first set of subjects (N=9) were used to demonstrate the technical feasibility of using fMRI to detect subtle changes in functional brain activation with 60 Hz MF exposure at 1800 μT. Second, a full study involving a larger cohort of subjects tested brain activation during 1) a finger tapping task (N=20), and 2) a mental rotation task (N=21); before and after a one-hour, 60 Hz, 3000 μT MF exposure. The results indicate significant changes in task-induced functional brain activation as a consequence of MF exposure. However, no impact on task performance was found. These results illustrate the potential of using fMRI to identify MF-induced changes in functional brain activation, suggesting that a one-hour 60 Hz, 3000 μT MF exposure can modulate activity in specific brain regions after the end of the exposure period (i.e., residual effects). We discuss the possibility that MF exposure at 60 Hz, 3000 μT may be capable of modulating cortical excitability via a modulation of synaptic plasticity processes.