The blood–brain barrier (BBB) is the protective sheath around the brain that protects the sensitive microenvironments of the brain. However, certain pathogens, viruses, and bacteria disrupt the endothelial barrier and cause infection and hence inflammation in meninges. Macromolecular therapeutics are unable to cross the tight junctions, thereby limiting their bioavailability in the brain. Recently, nanotechnology has brought a revolution in the field of drug delivery in brain infections. The nanostructures have high targeting accuracy and specificity to the receptors in the case of active targeting, which have made them the ideal cargoes to permeate across the BBB. In addition, nanomaterials with biomimetic functions have been introduced to efficiently cross the BBB to be engulfed by the pathogens. This review focuses on the nanotechnology-based drug delivery approaches for exploration in brain infections, including meningitis. Viruses, bacteria, fungi, or, rarely, protozoa or parasites may be the cause of brain infections. Moreover, inflammation of the meninges, called meningitis, is presently diagnosed using laboratory and imaging tests. Despite attempts to improve diagnostic instruments for brain infections and meningitis, due to its complicated and multidimensional nature and lack of successful diagnosis, meningitis appears almost untreatable. Potential for overcoming the difficulties and limitations related to conventional diagnostics has been shown by nanoparticles (NPs). Nanomedicine now offers new methods and perspectives to improve our knowledge of meningitis and can potentially give meningitis patients new hope. Here, we review traditional diagnosis tools and key nanoparticles (Au-NPs, graphene, carbon nanotubes (CNTs), QDs, etc.) for early diagnosis of brain infections and meningitis.

The aim of this paper is to present information gathered from studies regarding the current status and challenges of microplastics (MPs) in Mediterranean coastal counties. MPs are considered emerging pollutants, and their effect on fish and on the final consumer through the trophic food chain are of great concern. Studies from almost all of the Mediterranean coastal countries are gathered and discussed. The source of MPs, as well as their transfer and accumulation are reviewed. In addition, the laboratory techniques for sampling, analysis and characterization of MPs are presented. Moreover, the current regulations for MPs restrictions in Europe will be discussed. Finally, the authors present the current challenges on the topic and provide recommendations for future work.

Small and insular communities are sometimes not served by an efficient Wastewater Treatment Plant, and this is a hazard for both the environment and public health. A wastewater treatment apparatus based on the electrocoagulation process (EC) was tested with municipal wastewater from a small community in Northern Greece with a maximum of 6500 population equivalents. COD decrease was assessed under various parameters: current intensity, time duration, pH and use of Fe or Al electrodes. A simulation of meeting the community’s electricity needs with this apparatus was tested through RETScreen software. The results showed a satisfactory COD decrease through electrocoagulation which was affected by all the parameters mentioned; Fe electrodes could efficiently be used at 300 mA for 60 min for 55% COD removal. It was also shown that a photovoltaic panel system covers the electricity needs of the apparatus, thus no external electricity source is needed for its use. This apparatus could be used effectively by this community, so that the running costs are minimal.