A high power-conversion-efficiency voltage boost converter with MPPT for wireless sensor nodes (WSNs) is proposed in this paper. Since tiny wireless sensor nodes are all over complex environments, an efficient power management system (PMS) must be equipped to achieve long-term self-power supply and maintain regular operation. It is common to use Photovoltaic cells (PV) to harvest sunlight in the environment. However, most existing interface boost integrated circuits for the PV cell have low efficiency. This paper presents a voltage boost converter (VBC) with high power conversion efficiency (PCE) for WSNs. The integrated circuit (IC) designed in this paper includes a novel four-phase high-efficiency charge pump module, an ultra-low-power perturbation observation (P&O) MPPT control circuit module, a feedback control module, a nano-ampere current reference, etc. Manufactured in a standard 0.35 um complementary metal-oxide-semiconductor (CMOS) technology, the chip area is 3.15 mm × 2.43 mm. Test results demonstrate that when the output voltage of the PV cell is more than 0.5 V, VBC can improve the voltage to 3Vin, and the calculated voltage conversion efficiency can reach 99.4%. P&O MPPT algorithm makes output power improving 8.53%. Furthermore, when the output load current is 297uA, the output PCE achieves 85.1%.