White matter hyperintensities (WMH), also known as white matter osteoporosis, have been clinically proven to be associated with cognitive decline, the risk of cerebral infarction, and dementia. The existing computer automatic measurement technology for the segmentation of patients’ WMH does not have a good visualization and quantitative analysis. In this work, the author proposed a new WMH quantitative analysis and 3D reconstruction method for 3D reconstruction of high signal in white matter. At first, the author using ResUnet achieves the high signal segmentation of white matter and adds the attention mechanism into ResUnet to achieve more accurate segmentation. Afterwards, this paper used surface rendering to reconstruct the accurate segmentation results in 3D. Data experiments are conducted on the dataset collected from Shandong Province Third Hospital. After training, the Attention-Unet proposed in this paper is superior to other segmentation models in the segmentation of high signal in white matter and Dice coefficient and MPA reached 92.52% and 92.43%, respectively, thus achieving accurate 3D reconstruction and providing a new idea for quantitative analysis and 3D reconstruction of WMH.