This paper presents a novel approach for depth video enhancement. Given a high-resolution color video and its corresponding low-quality depth video, we improve the quality of the depth video by increasing its resolution and suppressing noise. For that, a weighted mode filtering method is proposed based on a joint histogram. When the histogram is generated, the weight based on color similarity between reference and neighboring pixels on the color image is computed and then used for counting each bin on the joint histogram of the depth map. A final solution is determined by seeking a global mode on the histogram. We show that the proposed method provides the optimal solution with respect to L₁ norm minimization. For temporally consistent estimate on depth video, we extend this method into temporally neighboring frames. Simple optical flow estimation and patch similarity measure are used for obtaining the high-quality depth video in an efficient manner. Experimental results show that the proposed method has outstanding performance and is very efficient, compared with existing methods. We also show that the temporally consistent enhancement of depth video addresses a flickering problem and improves the accuracy of depth video.

Recent works on machine learning have greatly advanced the accuracy of single image depth estimation. However, the resulting depth images are still over-smoothed and perceptually unsatisfying. This paper casts depth prediction from single image as a parametric learning problem. Specifically, we propose a deep variational model that effectively integrates heterogeneous predictions from two convolutional neural networks (CNNs), named global and local networks. They have contrasting network architecture and are designed to capture the depth information with complementary attributes. These intermediate outputs are then combined in the integration network based on the variational framework. By unrolling the optimization steps of Split Bregman iterations in the integration network, our model can be trained in an end-to-end manner. This enables one to simultaneously learn an efficient parameterization of the CNNs and hyper-parameter in the variational method. Finally, we offer a new data set of 0.22 million RGB-D images captured by Microsoft Kinect v2. Our model generates realistic and discontinuity-preserving depth prediction without involving any low-level segmentation or superpixels. Intensive experiments demonstrate the superiority of the proposed method in a range of RGB-D benchmarks, including both indoor and outdoor scenarios.

Drug discovery based on artificial intelligence has been in the spotlight recently as it significantly reduces the time and cost required for developing novel drugs. With the advancement of deep learning (DL) technology and the growth of drug-related data, numerous deep-learning-based methodologies are emerging at all steps of drug development processes. In particular, pharmaceutical chemists have faced significant issues with regard to selecting and designing potential drugs for a target of interest to enter preclinical testing. The two major challenges are prediction of interactions between drugs and druggable targets and generation of novel molecular structures suitable for a target of interest. Therefore, we reviewed recent deep-learning applications in drug–target interaction (DTI) prediction and de novo drug design. In addition, we introduce a comprehensive summary of a variety of drug and protein representations, DL models, and commonly used benchmark datasets or tools for model training and testing. Finally, we present the remaining challenges for the promising future of DL-based DTI prediction and de novo drug design.

Recent approaches for low-light image enhancement achieve excellent performance through supervised learning based on convolutional neural networks. However, it is still challenging to collect a large amount of low-/normal-light image pairs in real environments for training the networks. In this paper, we propose an unsupervised learning approach for single image low-light enhancement using the bright channel prior (BCP) that the brightest pixel in a small patch is likely to be close to 1. An unsupervised loss function is defined with the pseudo ground-truth generated using the BCP. An enhancement network, consisting of a simple encoder-decoder, is then trained using the unsupervised loss function. To the best of our knowledge, this is the first attempt that enhances a low-light image through unsupervised learning. Furthermore, we introduce saturation loss and self-attention map for preserving image details and naturalness in the enhanced result. The performance of the proposed method is validated on various public datasets. Experimental results demonstrate that the proposed unsupervised approach achieves competitive performance over state-of-the-arts based on supervised learning.

We present a descriptor, called fully convolutional self-similarity (FCSS), for dense semantic correspondence. Unlike traditional dense correspondence for estimating depth or optical flow, semantic correspondence estimation poses additional challenges due to intra-class appearance and shape variations among different instances within the same object or scene category. To robustly match points across semantically similar images, we formulate FCSS using local self-similarity (LSS), which is inherently insensitive to intra-class appearance variations. LSS is incorporated through a proposed convolutional self-similarity (CSS) layer, where the sampling patterns and the self-similarity measure are jointly learned in an end-to-end and multi-scale manner. Furthermore, to address shape variations among object instances, we propose a convolutional affine transformer (CAT) layer that estimates explicit affine transformation fields at each pixel to transform the sampling patterns and corresponding receptive fields. As training data for semantic correspondence is rather limited, we propose to leverage object candidate priors provided in most existing datasets and also correspondence consistency between object pairs to enable weakly-supervised learning. Experiments demonstrate that FCSS significantly outperforms conventional handcrafted descriptors and CNN-based descriptors on various benchmarks.

Stereo matching is one of the most popular techniques to estimate dense depth maps by finding the disparity between matching pixels on two, synchronized and rectified images. Alongside with the development of more accurate algorithms, the research community focused on finding good strategies to estimate the reliability, i.e., the confidence, of estimated disparity maps. This information proves to be a powerful cue to naively find wrong matches as well as to improve the overall effectiveness of a variety of stereo algorithms according to different strategies. In this paper, we review more than ten years of developments in the field of confidence estimation for stereo matching. We extensively discuss and evaluate existing confidence measures and their variants, from hand-crafted ones to the most recent, state-of-the-art learning based methods. We study the different behaviors of each measure when applied to a pool of different stereo algorithms and, for the first time in literature, when paired with a state-of-the-art deep stereo network. Our experiments, carried out on five different standard datasets, provide a comprehensive overview of the field, highlighting in particular both strengths and limitations of learning-based strategies.