Arid cold mountain-oasis transition zones are increasingly affected by climate variability, soil salinization and human disturbance, but conventional remote-sensing ecological indices mainly describe greenness, wetness, dryness and heat. This study developed a human-activity and salinization-response ecological indicator (HARSEI) for the Altai Mountains, a transboundary ecological barrier in Central Asia. Multi-source Google Earth Engine datasets for 2000, 2005, 2010, 2015, 2020 and 2024 were used to integrate NDVI, WET, NDBSI, LST and a salinization/structure response index (SRSI) into an Altai weighted remote sensing ecological index (AWRSEI) by principal component analysis. A reversely standardized human activity intensity index (HAI), derived from population density, night-time lights and land-use disturbance, was then fused with AWRSEI using entropy weights. Grade transition, spatial autocorrelation, Theil-Sen/Mann-Kendall trend tests, Hurst analysis, GeoDetector and random forest-SHAP were used to diagnose change and drivers. HARSEI was strongly correlated with conventional RSEI (mean Pearson = 0.9123; mean Spearman = 0.9022) but identified saline and disturbed transition zones more strictly. Eco-environmental quality deteriorated most during 2010-2015 and partly recovered during 2015-2020. High-quality areas were concentrated in northern and northwestern high-elevation forest, grassland and water-conservation zones, whereas low-quality areas occurred mainly in southern and southeastern piedmont, desert-oasis and intensively used areas. Vegetation condition, land-use structure, dryness, water supply, soil conditions and salinization response jointly shaped the pattern, with strong interaction enhancement. HARSEI provides a transferable framework for monitoring ecological quality and salinization risk in arid cold mountain regions.