Hancornia speciosa Gomes is a tree native to Brazil and has therapeutic potential for several diseases. Ethnopharmacological surveys have reported that the plant is used as a hypoglycemic agent and to lose weight. This study aimed to evaluate the effects of the aqueous extract from H. speciosa latex (LxHs) in a zebrafish model of diabetes. The extract was evaluated through high-performance thin-layer chromatography (HTPLC), nuclear magnetic resonance (NMR), and Fourier-transform infrared spectroscopy (FT-IR). We then tested treatments with LxHs (500, 1000, and 1500 mg/kg) by assessing blood glucose levels in alloxan-induced diabetic animals, and metformin was used as a control. The toxicity was evaluated through histopathology of the pancreas and biochemical assessment of serum levels of AST, ALT, creatinine, and urea. The extract was also assessed for acute toxicity through several parameters in embryos and adult animals. Finally, we performed in silico analysis through the SEA server and docking using the software GOLD. The phytochemical study showed the compounds cornoside, dihydrocornoide, and 1-O-methyl-myoinositol (bornesitol). The treatment with all doses of LxHs significantly decreased alloxan-induced hyperglycemia without any significant histological or biochemical abnormalities. No significant frequency of teratogenesis was observed in the embryos exposed to the extract, and no significant behavioral changes or deaths were observed in adult animals. In silico, the results showed a potential interaction between inositol and enzymes involved in carbohydrates’ metabolism. Overall, the results show a hypoglycemic activity of the extract in vivo, with no apparent toxicity. The computational studies suggest this could be at least partially due to the presence of bornesitol, since inositols can interact with carbohydrates’ enzymes.

O presente trabalho visa analisar a viabilidade do plantio e produção desta frutífera, como parte integrante de ações para o desenvolvimento rural amapaense, com base na qualificação e quantificação de dados físicos, físico-químicos e químicos, através do estudo da biometria dos frutos e sementes, propriedades físico-químicas como teor de umidade, cinzas, açúcares redutores e não-redutores, pH, sólidos solúveis totais (Brix), acidez total titulável (ATT), lipídios e determinação de presença de alguns minerais; indicativos de seu potencial nutricional, econômico e sustentável. De acordo com os resultados deste estudo, o plantio das mangabeiras do Amapá mostrou-se vantajoso e significativo, pois os frutos apresentam maior tamanho e rendimento em polpa, além de serem mais ácidos, propiciando assim a fabricação de doces, sorvetes e geleias em relação a materiais já selecionados da Paraíba; podendo ainda ser explorado como alternativa de fomento para uma economia baseada na utilização e conservação dos recursos naturais. Confirma-se também a possibilidade de promover o estímulo de plantação e produção, tornando-a coadjuvante de conservação do meio ambiente e resgate do solo, sendo uma alternativa de renda para as famílias que utilizam os meios de agricultura como forma de subsistência.Palavras-chave: Mangaba; Frutos; Amapá; Viabilidade econômica; Conservação.

Objective: In this work, we evaluated the chemical composition by chromatography coupled to mass spectrometry, antimicrobial and insecticidal activity of essential oils (TrEO) and nanoeffu-sion (NTrEO) of oil from Tetradenia riparia leaves. We also evaluated the acute toxicity in Mus musculus. The results showed that S. aureus showed greater susceptibility to TrEO, with a minimum inhibitory concentration (MIC) of 125 µg.mL-1, when compared to P. aeruginosa, E. coli, which presented a MIC of 250 µg.mL-1. There was a greater toxic effect on TrEO (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) larvae, effect on pupae (LC50 = 630.29 µg.mL-1) and NTrEO (LC50 = 713.68 µg.mL-1) and ovicide (LC50 = 631.184 µg.mL-1) and NTrEO (LC50 = 146.701 µg.mL-1) of Ae. aegypti after 24 h of exposure, when compared to other exposure periods. Chemical analysis re-vealed 20 components, aromadendrene oxide (23.47%) being the main component. Female and male mice were used to assess toxicity and oral administration of NTrEO to mice did not result in acute toxicity. Thus, the essential oil of T. riparia and its nanoemulsion have insecticidal and an-timicrobial potential for Ae. aegypti, S. aureus, E. coli, P. aeruginosa, and has a high toxicological safety threshold at the concentrations evaluated in this study.