Objective: The aim of the study was to determine the effect of exercise training on strength and balance in children with Down’s syndrome. Design: Randomized controlled trial. Setting: Rehabilitation school for special children. Subjects and intervention: Twenty-three children were randomized to intervention and control group. The intervention group (n = 12) underwent progressive resistive exercises for lower limbs and balance training for six weeks. The control group continued their regular activities followed at school. Outcome measure: A handheld dynamometer was used to measure the lower limb muscle strength. Balance was assessed by the balance subscale of Bruininks Oseretsky Test of Motor Proficiency (BOTMP). Results: Following the training, the children in the intervention group showed a statistically significant improvement (P < 0.05) in the lower limb strength of all the muscle groups assessed. The strength of knee extensors was 12.12 lbs in the control group versus 18.4 lbs in the experimental group; in hip flexors it was 12.34 lbs in the control group versus 16.66 lbs in the experimental group post-intervention. The balance of the children also improved significantly with an improvement in scores of the balance subscale of BOTMP (19.50 in the experimental group versus 9.00 in the control group, P = 0.001). Conclusion: This study suggests that a specific exercise training programme may improve the strength and balance in children with Down’s syndrome

To analyze and compare postural stability during static upright standing between children with cerebral palsy (CP) and age-matched peers with typical development (TD). Forty-five children with spastic CP (34 with diplegia and 11 with hemiplegia) and 45 children with TD aged 5 to 12 years were assessed using a posturography device. Postural stability was evaluated under 4 sensory conditions: eyes open and eyes closed on a firm surface; eyes open and eyes closed on a foam surface. Statistically significant differences were obtained between children with spastic diplegic CP and children with TD under all conditions involving visual and somatosensory conflicts (P < .05), but no significant differences were found between children with hemiplegic CP and children with TD. Children with spastic diplegic CP have increased postural instability under sensory conditions that involve both visual and somatosensory conflicts.

Background & objectives: Diabetic peripheral neuropathy (DPN) is a major complication of type 2 diabetes and have long term complications on the postural control of the affected population. The objectives of this study were to evaluate postural stability in patients with DPN and to examine correlation of Michigan Neuropathy Screening Instrument (MNSI) with duration of diabetes, age and postural stability measures. Methods: Participants were included if they had clinical neuropathy which was defined by MNSI. Sixty one patients gave their consent to participate in the study and were evaluated on posturography for postural stability measures in four conditions. Repeated measures of analysis of variance (RANOVA) was used to analyze the changes in postural stability measures in different conditions. Results: An increase in mean value of postural stability measures was observed for velocity moment 20.4±1.3, 24.3±2.2, 42.3±20.7, 59±43.03, mediolateral displacement 0.21±0.10, 0.22±0.18, 0.03±0.11, 0.34±0.18, and anteroposterior displacement 0.39 ± 0.09, 0.45±0.12, 0.47±0.13, 0.51±0.20 from EO to EC, EOF, and ECF, respectively. There was a significant difference (P<0.05) in participants with DPN, with greater sway amplitude on firm and foam surface in all the conditions. Moderate correlation of MNSI with age (r=0.43) and postural stability measures were also observed. Interpretation & conclusions: Evaluation of postural stability in Indian DPN population suggests balance impairments on either firm and foam surfaces, with greater likelihood of fall being on foam or deformable surfaces among elderly adults with neuropathy (CTRI/2011/07/001884).

Background1: Despite a growing interest in gaming rehabilitation for upper limb (UL) recovery post-stroke, studies investigating the effects of game-based rehabilitation incorporating functional games are lacking. Objective: To investigate the efficacy of an intensive, functional, gamified rehabilitation program compared to task-based training on UL motor function in acute/sub-acute stroke survivors. Methods: This randomized, multicenter, single-blind, clinical trial comprises 120 participants with unilateral stroke who were randomized to receive either gamified training (n = 64) using the ArmAble™ [experimental group (EG)] or task-based training (n = 56) in conjunction with conventional therapy for 2 hours per day, 6 days per week for 2 weeks, followed by UL rehabilitation for another 4 weeks at home. Primary outcomes evaluated by a blinded assessor included the Fugl-Meyer Assessment-Upper Extremity (FM-UE), and Action Research Arm Test (ARAT). Data were analyzed using a linear mixed-effect regression model. Results: The mean (standard deviation) age of the participants was 54.4 ± 11.7 years (78.1% men) in the EG and 57.7 ± 10.9 years (73.2% men) in the comparator group (CG). The median (interquartile range) time since stroke was 30.0 (54.0) days in the EG and 22.5 (45.0) days in the CG. Following the 2-week intervention, a statistically significant improvement was observed in the EG for the FM-UE [between-group mean differences (95% confidence interval): −3.9 (−6.5, −1.3); P = .003]; but not for the ARAT [−2.9 (−5.8, 0.0); P = .051]. Gains at 6 weeks were significantly greater in the EG for both FM-UE [−3.9 (−6.5, −1.3); P = .003]; and ARAT [−3.0 (−5.9, −0.0); P = .046]. Conclusion: Gamified rehabilitation using the ArmAble™ device has shown immediate and short-term improvement in UL function after acute/sub-acute stroke. Clinical Trials Registry Number: CTRI/2020/09/027651

Purpose: To estimate the levels of physical activity (PA) in community-dwelling adults with stroke and to correlate it with the quality of life (QoL). Methods: In a cross-sectional study, adults with chronic stroke were assessed for PA using Physical Activity Scale for Individuals with Physical Disabilities (PASIPD) and an accelerometer (Actigraph GT3X). QoL was assessed using Stroke Specific Quality of Life (SSQoL). Results: PA levels of our participants (n = 33; mean age 58.4 ± 12.1 years; mean FMA score 165.7 ± 31.1) were low with the mean activity of 252.9 ± 149.2 kilo counts per day and median energy expenditure of 77(44.6, 117.7) kilocalories per day. Median step count was 1635 (1084.9, 2434.3) steps per day. Mean time spent in sedentary and light activities were 504.1 ± 139 and 149.8 ± 68.3 minutes per day, respectively. Median time spent in moderate and vigorous activities were 1.6(1, 4.4) and 0(0,0) minutes per day, respectively. Median PASIPD score was 12.3(6.1, 25.8) MET. Hours/day. SSQoL was found to have a positive correlation with average kilo counts/day, kilo calories/day, steps/day and PASIPD (r = 0.48, p = .06; r = 0.46, p = .009; r = 0.44, p = .016; and r = 0.61, p ≤ .001 respectively). Conclusions: PA levels of adults with stroke living in the semi-urban region of India are low and do not meet the recommended guidelines.