Giancarlo Statti

Prof. Giancarlo Statti

Department of Pharmacy, Health and Nutritional Sciences, University of Calabria, Rende (CS), Italy
orcid

Research Focus & Metrics

Academic Career Length

27Years (2000-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 April 2008 in Mini-Reviews in Medicinal Chemistry
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Journal Article
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Rosa TundisRosa Tundis
Rosa Tundis
Monica Rosa LoizzoMonica Rosa Loizzo
Monica Rosa Loizzo
FMFederica Menichini
Federica Menichini
GSGiancarlo Statti
Giancarlo Statti
FMFrancesco Menichini
Francesco Menichini
Iridoids represent a large group of cyclopenta[c]pyran monoterpenoids that occur wide-spread in nature, mainly in dicotyledonous plant families like Apocynaceae, Scrophulariaceae, Diervillaceae, Lamiaceae, Loganiaceae and Rubiaceae. Recently, more extensive studies revealed that iridoids exhibit a wide range of bioactivity, such as neuroprotective, antinflammatory and immunomodulator, hepatoprotective and cardioprotective effects. Anticancer, antioxidant, antimicrobic, hypoglycaemic, hypolipidemic, choleretic, antispasmodic and purgative properties were also reported. The aim of the present review is to discuss the recent developments on biological and pharmacological activities of iridoids, supporting the new therapeutic possibilities for the use of these compounds.

20 October 2016 in Molecules
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Journal Article
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Mariangela MarrelliMariangela Marrelli
Mariangela Marrelli
Filomena ConfortiFilomena Conforti
Filomena Conforti
Fabrizio AranitiFabrizio Araniti
Fabrizio Araniti
GSGiancarlo Statti
Giancarlo Statti
Obesity is one of the greatest public health problems. This complex condition has reached epidemic proportions in many parts of the world, and it constitutes a risk factor for several chronic disorders, such as hypertension, cardiovascular diseases and type 2 diabetes. In the last few decades, several studies dealt with the potential effects of natural products as new safe and effective tools for body weight control. Saponins are naturally-occurring surface-active glycosides, mainly produced by plants, whose structure consists of a sugar moiety linked to a hydrophobic aglycone (a steroid or a triterpene). Many pharmacological properties have been reported for these compounds, such as anti-inflammatory, immunostimulant, hypocholesterolemic, hypoglycemic, antifungal and cytotoxic activities. The aim of this review is to provide an overview of recent studies about the anti-obesity therapeutic potential of saponins isolated from medicinal plants. Results on the in vitro and in vivo activity of this class of phytochemicals are here presented and discussed. The most interesting findings about their possible mechanism of action and their potential health benefits in the treatment of obesity are reported, as well.

1 February 2008 in Journal of Ethnopharmacology
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Journal Article
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Filomena ConfortiFilomena Conforti
Filomena Conforti
SSSilvio Sosa
Silvio Sosa
Mariangela MarrelliMariangela Marrelli
Mariangela Marrelli
FMFederica Menichini
Federica Menichini
GSGiancarlo Statti
Giancarlo Statti
RLRoberto Della Loggia
Roberto Della Loggia

20 March 2008 in Chemistry & Biodiversity
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Journal Article
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Monica Rosa LoizzoMonica Rosa Loizzo
Monica Rosa Loizzo
ASAntoine M. Saab
Antoine M. Saab
Rosa TundisRosa Tundis
Rosa Tundis
GSGiancarlo Statti
Giancarlo Statti
FMFrancesco Menichini
Francesco Menichini
HDHans Wilhelm Doerr
Hans Wilhelm Doerr
The chemical composition of the essential oils of Laurus nobilis, Juniperus oxycedrus ssp. oxycedrus, Thuja orientalis, Cupressus sempervirens ssp. pyramidalis, Pistacia palaestina, Salvia officinalis, and Satureja thymbra was determined by GC/MS analysis. Essential oils have been evaluated for their inhibitory activity against SARS‐CoV and HSV‐1 replication in vitro by visually scoring of the virus‐induced cytopathogenic effect post‐infection. L. nobilis oil exerted an interesting activity against SARS‐CoV with an IC50 value of 120 μg/ml and a selectivity index (SI) of 4.16. This oil was characterized by the presence of β‐ocimene, 1,8‐cineole, α‐pinene, and β‐pinene as the main constituents. J. oxycedrus ssp. oxycedrus oil, in which α‐pinene and β‐myrcene were the major constituents, revealed antiviral activity against HSV‐1 with an IC50 value of 200 μg/ml and a SI of 5.


27 October 2006 in Phytotherapy Research
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Monica Rosa LoizzoMonica Rosa Loizzo
Monica Rosa Loizzo
ASAtaa Said
Ataa Said
Rosa TundisRosa Tundis
Rosa Tundis
KRKhaled Rashed
Khaled Rashed
GSGiancarlo Statti
Giancarlo Statti
FMFrancesco Menichini
Francesco Menichini
In our screening program for antihypertensive properties of plants, the leaves of Ailanthus excelsa (Roxb), a plant used in Egyptian traditional medicine, were analysed. Chromatographic separation of A. excelsa MeOH extract yielded six flavonoids for the first time from this species, namely apigenin, luteolin, kaempferol‐3‐O‐α‐arabinopyranoside, kaempferol‐3‐O‐β‐galactopyranoside, quercetin‐3‐O‐α‐arabinopyranoside and luteolin‐7‐O‐β‐glucopyranoside. The in vitro hypotensive activities of the MeOH extract and the isolated compounds were elucidated. All the flavonoids tested exhibited ACE inhibitory activity, in particular the most active compound was kaempferol‐3‐O‐β‐galactopyranoside with an IC50 value of 260 µm. Copyright © 2006 John Wiley & Sons, Ltd.