The consequences of the extractive and disconnected relationship with nature that has dominated past and current sustainability approaches are now being witnessed. A harmonious relationship with nature needs to be reestablished to guide how we can live, act and respond to the global climate emergency. Regenerative development has emerged as a process which enables the reconnection between human and natural systems to create the necessary conditions for a healthy and thriving future. While several frameworks and tools have been developed to support the implementation of regenerative development practices, few deal specifically with decision-making and its associated challenges and opportunities. Responding to this, the purpose of this paper is to present the development of a novel decision-making framework for regenerative precinct development. It is an evidence-based framework established from the key findings of a qualitative case study investigation into the decision-making approaches of regenerative precinct developments. It is a visual guiding framework that poses challenging questions to enable decision-makers to structure and align their thinking, decisions and actions with the fundamental principles of regenerative development. This paper discusses the framework’s development, its key features and theoretical basis, and its potential to influence decision-making practices towards regenerative development.