Recently, using artificial intelligence (AI) in drug discovery has received much attention since it significantly shortens the time and cost of developing new drugs. Deep learning (DL)-based approaches are increasingly being used in all stages of drug development as DL technology advances, and drug-related data grows. Therefore, this paper presents a systematic Literature review (SLR) that integrates the recent DL technologies and applications in drug discovery Including, drug–target interactions (DTIs), drug–drug similarity interactions (DDIs), drug sensitivity and responsiveness, and drug-side effect predictions. We present a review of more than 300 articles between 2000 and 2022. The benchmark data sets, the databases, and the evaluation measures are also presented. In addition, this paper provides an overview of how explainable AI (XAI) supports drug discovery problems. The drug dosing optimization and success stories are discussed as well. Finally, digital twining (DT) and open issues are suggested as future research challenges for drug discovery problems. Challenges to be addressed, future research directions are identified, and an extensive bibliography is also included.

Machine learning models are used today to solve problems within a broad span of disciplines. If the proper hyperparameter tuning of a machine learning classifier is performed, significantly higher accuracy can be obtained. In this paper, a comprehensive comparative analysis of various hyperparameter tuning techniques is performed; these are Grid Search, Random Search, Bayesian Optimization, Particle Swarm Optimization (PSO), and Genetic Algorithm (GA). They are used to optimize the accuracy of six machine learning algorithms, namely, Logistic Regression (LR), Ridge Classifier (RC), Support Vector Machine Classifier (SVC), Decision Tree (DT), Random Forest (RF), and Naive Bayes (NB) classifiers. To test the performance of each hyperparameter tuning technique, the machine learning models are used to solve an Arabic sentiment classification problem. Sentiment analysis is the process of detecting whether a text carries a positive, negative, or neutral sentiment. However, extracting such sentiment from a complex derivational morphology language such as Arabic has been always very challenging. The performance of all classifiers is tested using our constructed dataset both before and after the hyperparameter tuning process. A detailed analysis is described, along with the strengths and limitations of each hyperparameter tuning technique. The results show that the highest accuracy was given by SVC both before and after the hyperparameter tuning process, with a score of 95.6208 obtained when using Bayesian Optimization.

Unmanned aerial vehicles (UAVs) are now extensively used in a wide variety of applications, including a key role within opportunistic wireless networks. These types of opportunistic networks are considered well suited for infrastructure-less areas, or urban areas with overloaded cellular networks. For these networks, UAVs are envisioned to complement and support opportunistic network performance; however, the short battery life of commercial UAVs and their need for frequent charging can limit their utility. This paper addresses the challenge of charging station placement in a UAV-aided opportunistic network. We implemented three clustering approaches, namely, K-means, Density-Based Spatial Clustering of Applications with Noise (DBSCAN), and random clustering, with each clustering approach being examined in combination with Epidemic, Spray and Wait, and State-Based Campus Routing (SCR) routing protocols. The simulation results show that determining the charging station locations using K-means clustering with three clusters showed lower message delay and higher success rate than deciding the charging station location either randomly or using DBSCAN regardless of the routing strategy employed between nodes.

Sentiment Analysis (SA) is an increasingly important field of study, also known as opinion mining, as it has the ability to identify the emotional tone of a source material as being either positive, negative, or neutral. Simply, SA digests natural languages and extracts insights, making it extremely useful to gain an overview of the public opinion in a certain issue, topic, or even a product. With the vast amount of information over social network platforms, shared views, website reviews, and blogs comes the importance of SA. Arabic is a rich language with extremely complex inflectional and derivational morphology making sentiment analysis in Arabic text more challenging. In this paper, we propose a novel approach to enhance the accuracy of Arabic Sentiment Analysis (ASA). In this aspect, nine supervised machine learning algorithms have been implemented for ASA. Three of these classifiers have never been used before in ASA classification, namely, they are Ridge, Gradient Boosting, and Multi-layer Perceptron. The performance of all nine classifiers is tested using our constructed dataset. The dataset contains 6318 reviews written in different forms of Arabic language and prepared manually by gathering hotel reviews from Booking.com website.