Linear Discriminant Analysis (LDA) is a very common technique for dimensionality reduction problems as a pre-processing step for machine learning and pattern classification applications. At the same time, it is usually used as a black box, but (somet

Wireless sensor network (WSN) technologies are considered one of the key research areas in computer science and the healthcare application industries for improving the quality of life. The purpose of this paper is to provide a snapshot of current developments and future direction of research on wearable and implantable body area network systems for continuous monitoring of patients. This paper explains the important role of body sensor networks in medicine to minimize the need for caregivers and help the chronically ill and elderly people live an independent life, besides providing people with quality care. The paper provides several examples of state of the art technology together with the design considerations like unobtrusiveness, scalability, energy efficiency, security and also provides a comprehensive analysis of the various benefits and drawbacks of these systems. Although offering significant benefits, the field of wearable and implantable body sensor networks still faces major challenges and open research problems which are investigated and covered, along with some proposed solutions, in this paper.

Recently, using artificial intelligence (AI) in drug discovery has received much attention since it significantly shortens the time and cost of developing new drugs. Deep learning (DL)-based approaches are increasingly being used in all stages of drug development as DL technology advances, and drug-related data grows. Therefore, this paper presents a systematic Literature review (SLR) that integrates the recent DL technologies and applications in drug discovery Including, drug–target interactions (DTIs), drug–drug similarity interactions (DDIs), drug sensitivity and responsiveness, and drug-side effect predictions. We present a review of more than 300 articles between 2000 and 2022. The benchmark data sets, the databases, and the evaluation measures are also presented. In addition, this paper provides an overview of how explainable AI (XAI) supports drug discovery problems. The drug dosing optimization and success stories are discussed as well. Finally, digital twining (DT) and open issues are suggested as future research challenges for drug discovery problems. Challenges to be addressed, future research directions are identified, and an extensive bibliography is also included.

COVID-19 is a pandemic that has affected over 170 countries around the world. The number of infected and deceased patients has been increasing at an alarming rate in almost all the affected nations. Forecasting techniques can be inculcated thereby assisting in designing better strategies and in taking productive decisions. These techniques assess the situations of the past thereby enabling better predictions about the situation to occur in the future. These predictions might help to prepare against possible threats and consequences. Forecasting techniques play a very important role in yielding accurate predictions. This study categorizes forecasting techniques into two types, namely, stochastic theory mathematical models and data science/machine learning techniques. Data collected from various platforms also play a vital role in forecasting. In this study, two categories of datasets have been discussed, i.e., big data accessed from World Health Organization/National databases and data from a social media communication. Forecasting of a pandemic can be done based on various parameters such as the impact of environmental factors, incubation period, the impact of quarantine, age, gender and many more. These techniques and parameters used for forecasting are extensively studied in this work. However, forecasting techniques come with their own set of challenges (technical and generic). This study discusses these challenges and also provides a set of recommendations for the people who are currently fighting the global COVID-19 pandemic.