Dr. Fernando Cuenú-Cabezas
University of Quindío, Armenia, Quindío, Colombia
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Academic Career Length
15Years (2012-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Alberto Aragón-Muriel
VIVIANA REYES MARQUEZFCFarrah Cañavera-Buelvas
Farrah Cañavera-BuelvasJUJesus Ricardo Parra Unda
Jesus Ricardo Parra UndaFernando Cuenú-Cabezas
DAVID MORALES-MORALES +4
Within the current challenges in medicinal chemistry, the development of new and better therapeutic agents effective against infectious diseases produced by bacteria, fungi, viruses, and parasites stands out. With chemotherapy as one of the main strategies against these diseases focusing on the administration of organic and inorganic drugs, the latter is generally based on the synergistic effect produced by the formation of metal complexes with biologically active organic compounds. In this sense, Schiff bases (SBs) represent and ideal ligand scaffold since they have demonstrated a broad spectrum of antitumor, antiviral, antimicrobial, and anti-inflammatory activities, among others. In addition, SBs are synthesized in an easy manner from one-step condensation reactions, being thus suitable for facile structural modifications, having the imine group as a coordination point found in most of their metal complexes, and promoting chelation when other donor atoms are three, four, or five bonds apart. However, despite the wide variety of metal complexes found in the literature using this type of ligands, only a handful of them include on their structures tridentate SBs ligands and their biological evaluation has been explored. Hence, this review summarizes the most important antimicrobial activity results reported this far for pincer-type complexes (main group and d-block) derived from SBs tridentate ligands.
1 January 2018 in Journal of Molecular Structure
Journal Article
Fernando Cuenú-CabezasJLJennifer Londoño-Salazar
Jennifer Londoño-SalazarJTJohn Eduard Torres
John Eduard TorresRARodrigo Abonia
Rodrigo Abonia
DRD'Vries Fernando Richard
D'Vries Fernando Richard1 May 2019 in Journal of Molecular Structure
Journal Article
Fernando Cuenú-CabezasARAndrés Restrepo-Acevedo
Andrés Restrepo-Acevedo
MIMaría Isabel-Murillo
María Isabel-Murillo
JTJohn Eduard Torres
John Eduard TorresRMRodolfo Moreno-Fuquen
Rodolfo Moreno-Fuquen
CLChristian W. Lehmann
Christian W. Lehmann
+3
Journal Article
DFDorancelly Fernandez
Dorancelly FernandezARAndrés Restrepo-Acevedo
Andrés Restrepo-AcevedoCRCristian Rocha
Cristian RochaRLRonan Le Lagadec
Ronan Le Lagadec
Rodrigo AboniaFernando Cuenú-Cabezas +2
The azo-azomethine imines, R1-N=N-R2-CH=N-R3, are a class of active pharmacological ligands that have been prominent antifungal, antibacterial, and antitumor agents. In this study, four new azo-azomethines, R1 = Ph, R2 = phenol, and R3 = pyrazol-Ph-R’ (R = H or NO2), have been synthesized, structurally characterized using X-ray, IR, NMR and UV–Vis techniques, and their antifungal activity evaluated against certified strains of Candida albicans and Cryptococcus neoformans. The antifungal tests revealed a high to moderate inhibitory activity towards both strains, which is regulated as a function of both the presence and the location of the nitro group in the aromatic ring of the series. These biological assays were further complemented with molecular docking studies against three different molecular targets from each fungus strain. Molecular dynamics simulations and binding free energy calculations were performed on the two best molecular docking results for each fungus strain. Better affinity for active sites for nitro compounds at the “meta” and “para” positions was found, making them promising building blocks for the development of new Schiff bases with high antifungal activity.
Journal Article
JLJennifer Londoño-Salazar
Jennifer Londoño-SalazarARAndrés Camilo Restrepo-Acevedo
Andrés Camilo Restrepo-AcevedoJTJohn Eduard Torres
John Eduard TorresRodrigo AboniaLSLaura Andrea Svetaz
Laura Andrea SvetazFernando Cuenú-Cabezas +2
In this study, we report the synthesis of eight Schiff bases (3–10) type N-heterocycle (N-het) using conventional refluxing conditions as well as different eco-friendly techniques such as grinding, thermal fusion, microwave irradiation (MWI) and ultrasound, all of them in the presence of a catalytic amount of acetic acid. These procedures had the additional advantage of being environmentally friendly and high-yield, making these protocols an alternative for Schiff-base syntheses. The obtained Schiff bases were coordinated to palladium, generating new complexes of type [Pd2Cl4(N-het)2]. Complexes [Pd2Cl4(5)2] and [Pd2Cl4(9)2] showed high activity and selectivity for a model Mizoroki–Heck C-C coupling reaction of styrene with iodobenzene and bromobenzaldehydes. All compounds and complexes were evaluated for antifungal activity against clinically important fungi such as Candida albicans and Cryptococcus neoformans. Although the Schiff bases (3–10) showed low antifungal activity against both fungi, some of their palladium complexes such as [Pd2Cl4(3)2], [Pd2Cl4(5)2], [Pd2Cl4(8)2] and [Pd2Cl4(10)2] showed comparatively higher antifungal effects mainly against C. neoformans. The product of the Mizoroki–Heck-type C-C coupling reactions, 4-styrylbenzaldehyde, was isolated and purified to be later used in the synthesis of four new nitrophenylpyrazole derivatives of styrylimine, which also displayed antifungal activity, especially against C. neoformans.
1 October 2015 in Journal of Molecular Structure
Journal Article
AOAndrés Felipe Cruz Ortiz
Andrés Felipe Cruz Ortiz
ALAlberto Sánchez López
Alberto Sánchez López
ARAlejandro García Ríos
Alejandro García Ríos
Fernando Cuenú-CabezasCCCiro Eduardo Rozo Correa
Ciro Eduardo Rozo Correa
About Me
FERNANDO CUENU CABEZAS Ph.D.
Cvlac: https://scienti.minciencias.gov.co/cvlac/visualizador/generarCurriculoCv.do?cod_rh=0000384275; https://orcid.org/0000-0003-2997-6720, Scopus Author ID: 55520085600; SciProfiles: 1866217.
Doctor of Science, Chemistry, UNIVERSIDAD DEL VALLE, Cali- Colombia, November 2011, SYNTHESIS AND CHARACTERIZATION OF RHODE(I) AND PALLADIUM(II) COMPLEXES WITH N-HETEROCYCLES DERIVED LIGANDS AND STUDY OF THEIR APPLICATIONS IN HYDROFORMYLING AND C-C MIZOROKI-HECK COUPLING REACTIONS. Meritorious Thesis. Master of Science, Chemistry, UNIVERSIDAD DEL VALLE, Cali-Colombia, March 2000, SYNTHESIS, CHARACTERIZATION AND THERMAL STUDIES OF TRIPHENYLPHOSPHIN RUTENIUM II COMPLEXES WITH N-HETEROCYCLIC LIGANDS AND CATALYTIC ACTIVITY OF THE COMPLEXES IN THE HYDROGENATION IN HOMOGENIC PHASE OF 1,5-COD AND HYDROFORMILATION OF CANFENO. Chemistry, UNIVERSIDAD DEL VALLE, Cali-Colombia, November 1995, SYNTHESIS, CHARACTERIZATION AND STUDY OF THE PHYSICOCHEMICAL PROPERTIES OF RuCl(PPh3)2(N-HET)2 TYPE COMPLEXES. Director, Chemistry Program at the Universidad del Quindío Aug. 2017- June 2023. Associate professor at Universidad del Quindío 2002-present; directed undergraduate courses (Inorganic I, Inorganic II, Inorganic III) and PhD courses (Advanced Inorganic Chemistry, Organometallic Chemistry, Kinetics and Mechanisms of Reactions in Inorganic Chemistry and Catalysis). Member of the Colombian Society of Catalysis, Iberoamerican Federation of Catalysis Societies (FISOCAT).