Yu-Fon Chen

Dr. Yu-Fon Chen


Research Focus & Metrics

Academic Career Length

13Years (2014-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 June 2017 in Acta Biomaterialia
Verified
Journal Article
Closed access
YCYu-Fon Chen
Yu-Fon Chen
ASAi-Li Shiau
Ai-Li Shiau
SCSue-Joan Chang
Sue-Joan Chang
NFNai-Shin Fan
Nai-Shin Fan
CWChungteng Wang
Chungteng Wang
JJJeng-Shiung Jan
Jeng-Shiung Jan

12 November 2021 in Pharmaceutics
Verified
Journal Article
Open access
PDF file
YHYuan-Pin Hung
Yuan-Pin Hung
YCYu-Fon Chen
Yu-Fon Chen
PTPei-Jane Tsai
Pei-Jane Tsai
IHI-Hsiu Huang
I-Hsiu Huang
WKWen-Chien Ko
Wen-Chien Ko
JJJeng-Shiung Jan
Jeng-Shiung Jan
Bacteria-targeting nanomaterials have been widely used in the diagnosis and treatment of bacterial infectious diseases. These nanomaterials show great potential as antimicrobial agents due to their broad-spectrum antibacterial capacity and relatively low toxicity. Recently, nanomaterials have improved the accurate detection of pathogens, provided therapeutic strategies against nosocomial infections and facilitated the delivery of antigenic protein vaccines that induce humoral and cellular immunity. Biomaterial implants, which have traditionally been hindered by bacterial colonization, benefit from their ability to prevent bacteria from forming biofilms and spreading into adjacent tissues. Wound repair is improving in terms of both the function and prevention of bacterial infection, as we tailor nanomaterials to their needs, select encapsulation methods and materials, incorporate activation systems and add immune-activating adjuvants. Recent years have produced numerous advances in their antibacterial applications, but even further expansion in the diagnosis and treatment of infectious diseases is expected in the future.

Verified
Journal Article
Open access
PDF file
CHChieh-Hung Huang
Chieh-Hung Huang
YCYu-Yi Chan
Yu-Yi Chan
Ping-Chung KuoPing-Chung Kuo
Ping-Chung Kuo
YCYu-Fon Chen
Yu-Fon Chen
RCRen-Jie Chang
Ren-Jie Chang
TWTian-Shung Wu
Tian-Shung Wu
Phytochemical investigation of the roots and stems of Illigera luzonensis afforded two new aporphine alkaloids (1) and (2), one new bisdehydroaporphine alkaloid (3), and one new benzenoid (4), along with 28 known structures. The structures of new compounds were elucidated by spectral and MS analysis. Among the isolated compounds, (1) and (4–13) were subjected into the examination for their inhibitory effects on the aggregation of washed rabbit platelets.

Verified
Journal Article
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YCYu-Yi Chan
Yu-Yi Chan
SJShin-Hun Juang
Shin-Hun Juang
GHGuan-Jhong Huang
Guan-Jhong Huang
YLYu-Ren Liao
Yu-Ren Liao
YCYu-Fon Chen
Yu-Fon Chen
TWTian-Shung Wu
Tian-Shung Wu
Phytochemical investigation of the heartwood of Michelia compressa afforded forty-four compounds, which were identified by comparison of experimental and literature analytical and spectroscopic data. Some compounds were evaluated for their anti-inflammatory and anticancer bioactivities. The result showed that soemerine (1) and cyathisterol (2) exhibited significant nitric oxide (NO) inhibition, with IC50 values of 8.5 ± 0.3 and 9.6 ± 0.5 µg/mL, respectively. In addition, liriodenine (3) and oliveroline (4) exhibited cytotoxicity to human nasopharyngeal carcinoma (NPC-TW01), non-small cell lung carcinoma (NCI-H226), T cell leukemia (Jurkat), renal carcinoma (A498), lung carcinoma (A549) and fibrosarcoma (HT1080) cell lines with IC50 values in the range of 15.7–3.68 μM.

13 August 2019 in International Journal of Peptide Research and Therapeutics
Verified
Journal Article
Closed access
PDF file
YTYu-Cheng Tsai
Yu-Cheng Tsai
CTChen-Chi Tang
Chen-Chi Tang
HWHsu-Heng Wu
Hsu-Heng Wu
YWYu-Shiang Wang
Yu-Shiang Wang
YCYu-Fon Chen
Yu-Fon Chen

Verified
Journal Article
Open access
PDF file
YCYu-Yi Chan
Yu-Yi Chan
SJShin-Hun Juang
Shin-Hun Juang
GHGuan-Jhong Huang
Guan-Jhong Huang
YLYu-Ren Liao
Yu-Ren Liao
YCYu-Fon Chen
Yu-Fon Chen
TWTian-Shung Wu
Tian-Shung Wu
The authors wish to make two changes to their published paper [1].