Yann Nguyen

Prof. Dr. Yann Nguyen


Research Focus & Metrics

Academic Career Length

15Years (2012-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 March 2016 in Journal of Controlled Release
Verified
Journal Article
Closed access
NKNaila El Kechai
Naila El Kechai
EMElisabeth Mamelle
Elisabeth Mamelle
YNYann Nguyen
Yann Nguyen
NHNicolas Huang
Nicolas Huang
VNValérie Nicolas
Valérie Nicolas
ABAmélie Bochot
Amélie Bochot

1 February 2017 in Hearing Research
Verified
Journal Article
Open access
DSDaniele De Seta
Daniele De Seta
RTRenato Torres
Renato Torres
FRFrancesca Yoshie Russo
Francesca Yoshie Russo
EFEvelyne Ferrary
Evelyne Ferrary
GKGuillaume Kazmitcheff
Guillaume Kazmitcheff
YNYann Nguyen
Yann Nguyen
Cochlear implant insertion should be as least traumatic as possible in order to reduce trauma to the cochlear sensory structures. The force applied to the cochlea during array insertion should be controlled to limit insertion-related damage. The relationship between insertion force and histological traumatism remains to be demonstrated. Twelve freshly frozen cadaveric temporal bones were implanted with a long straight electrodes array through an anterior extended round window insertion using a motorized insertion tool with real-time measurement of the insertion force. Anatomical parameters, measured on a pre-implantation cone beam CT scan, position of the array and force metrics were correlated with post-implantation scanning electron microscopy images and histological damage assessment. An atraumatic insertion occurred in six cochleae, a translocation in five cochleae and a basilar membrane rupture in one cochlea. The translocation always occurred in the 150- to 180-degree region. In the case of traumatic insertion, different force profiles were observed with a more irregular curve arising from the presence of an early peak force (30 ± 18.2 mN). This corresponded approximately to the first point of contact of the array with the lateral wall of the cochlea. Atraumatic and traumatic insertions had significantly different force values at the same depth of insertion (p < 0.001, two-way ANOVA), and significantly different regression lines (y = 1.34x + 0.7 for atraumatic and y = 3.37x + 0.84 for traumatic insertion, p < 0.001, ANCOVA). In the present study, the insertion force was correlated with the intracochlear trauma. The 150- to 180-degree region represented the area at risk for scalar translocation for this straight electrodes array. Insertion force curves with different sets of values were identified for traumatic and atraumatic insertions; these values should be considered during motorized insertion of an implant so as to be able to modify the insertion parameters (e.g axis of insertion) and facilitate preservation of endocochlear structures.

26 May 2020 in European Archives of Oto-Rhino-Laryngology
Verified
Journal Article
Closed access
PDF file
SVSykopetrites Vittoria
Sykopetrites Vittoria
GLGhizlene Lahlou
Ghizlene Lahlou
RTRenato Torres
Renato Torres
HDHannah Daoudi
Hannah Daoudi
IMIsabelle Mosnier
Isabelle Mosnier
OSOlivier Sterkers
Olivier Sterkers

16 November 2016 in Otolaryngology–Head and Neck Surgery
Verified
Journal Article
Closed access
PDF file
RTRenato Torres
Renato Torres
YNYann Nguyen
Yann Nguyen
AVAntoine Vanier
Antoine Vanier
MSMustapha Smail
Mustapha Smail
EFEvelyne Ferrary
Evelyne Ferrary
DBDaniele Bernardeschi
Daniele Bernardeschi

7 December 2012 in Acta Oto-Laryngologica
Verified
Journal Article
Closed access
YNYann Nguyen
Yann Nguyen
IMIsabelle Mosnier
Isabelle Mosnier
SBStéphanie Borel
Stéphanie Borel
EAEmmanuelle Ambert-Dahan
Emmanuelle Ambert-Dahan
DBDidier Bouccara
Didier Bouccara
OSOlivier Sterkers
Olivier Sterkers
Conclusion: Residual hearing could be preserved with various arrays ranging from 16 to 18 mm in insertion length and 0.25 to 0.5 mm tip diameter. Whether array insertion is performed through a cochleostomy or a round window, tip diameter is an essential criterion for the array design to improve hearing preservation results. Objectives: The goal of this study was to report the outcome of patients implanted with electric acoustic cochlear implants with various surgical techniques and array designs. Methods: Thirty-two implanted ears (30 patients) were included in this retrospective study. Three array models were inserted: Contour Advance implant (n = 16), Nucleus Hybrid-L (n = 12), and Med-El Flex EAS (n = 4). Postoperative pure tone audiometry was performed at 3 and 12 months after implantation. Results: Three months postoperatively, hearing preservation within 30 dB was achieved in 50%, 50%, and 84% cases of patients implanted with a Contour Advance, Flex-EAS, and Hybrid-L, respectively. Two patients (Hybrid-L group) had a delayed sudden hearing loss (> 30 dB) 3 months postoperatively and three patients (Contour Advance group) had total hearing loss at 1 year. Best results were achieved using arrays with small tip diameters. Cochleostomy or round window insertion did not affect hearing preservation results.

1 January 2021 in International Journal of Pharmaceutics
Verified
Journal Article
Closed access
CJCéline Jaudoin
Céline Jaudoin
FAFlorence Agnely
Florence Agnely
YNYann Nguyen
Yann Nguyen
EFEvelyne Ferrary
Evelyne Ferrary
ABAmélie Bochot
Amélie Bochot