This paper evaluates the flexural static and cyclic behaviour of cement-treated mixtures of reclaimed asphalt pavement (RAP) and lateritic soil (LS). Flexural strength and resilient modulus increased with RAP percentage. Strain at break increased with higher RAP and lower cement amounts, increasing mixtures flexibility. Higher cement contents led to stronger and stiffer mixtures. Strain-based fatigue relationships were obtained. Mechanistic analyses showed that the fatigue life of cement-treated recycled base layers of RAP and LS increases with RAP percentage and with the thicknesses of asphalt wearing course and recycled base layer. The effect of cement content depends on the thickness of the layers.