Chenpi, or dried tangerine peel, is a traditional Chinese ingredient valued in medicine and edible for its digestive and respiratory benefits. The geographical origin of Chenpi is important, as it can impact its quality, active compounds and market value. This study develops a strategy to distinguish Chenpi samples on its origin. Thirty-nine samples from eight regions in Xinhui district (Guangdong, China) are analyzed by gas chromatography (GC) and mid-infrared (MIR) technique. Four machine learning methods are employed to establish discrimination models based on GC and MIR data, with two mid-level data fusion strategies to combine the data. The results show that data fusion significantly improves Chenpi origin discrimination. The K-nearest neighbors and artificial neural network models, using modified mid-level data fusion, provide the best performance, misclassified only one sample. Machine learning in combination with modified mid-level data fusion strategy provides effective classification of Chenpi samples from different geographical origins.