This page has only limited features, please log in for full access.
The functional components of vibrating mesh nebulizers are a piezoelectric ceramic with a mesh mounted on one side, a reservoir, and a driving circuit. The piezoelectric material vibrates at a specific intrinsic frequency, and when the mechanical resonance frequency of the piezoelectric ceramic and the frequency of the applied electrical signal match, the vibration amplitude of the ceramic is greatest. In the present study, nebulizing performances were tested with respect to driving voltage amplitude after automatic resonance frequency tuning (ARFT) and/or impedance matching (IM) for salbutamol and glycerol solutions. A 1% mismatch of resonance frequency reduced the output rate by 11.0~30.1% and increased particle size by 1.6~7.7% and power consumption increased by 6.6~13.6%. Driving at 30 Vpp after ARFT and IM increased output rate by 45% and decreased power consumption by 31% compared with operation at nominal resonance frequency without IM at 50 Vpp. Nebulization of viscous solutions was also enhanced by applying ARFT with IM. The study shows the application of ARFT with IM improves vibrating mesh nebulizer performance and reduces power consumption.
Sang-Hyub Moon; Kyung Hwa Chang; Hyun Mok Park; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers. Applied Sciences 2021, 11, 1296 .
AMA StyleSang-Hyub Moon, Kyung Hwa Chang, Hyun Mok Park, Bong Joo Park, Sun Kook Yoo, Ki Chang Nam. Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers. Applied Sciences. 2021; 11 (3):1296.
Chicago/Turabian StyleSang-Hyub Moon; Kyung Hwa Chang; Hyun Mok Park; Bong Joo Park; Sun Kook Yoo; Ki Chang Nam. 2021. "Effects of Driving Frequency and Voltage on the Performances of Vibrating Mesh Nebulizers." Applied Sciences 11, no. 3: 1296.
Recent reports on mesh nebulizers suggest the possibility of stable nebulization of various therapeutic protein drugs. In this study, the in vitro performance and drug stability of jet and mesh nebulizers were examined for dornase alfa and compared with respect to their lung delivery efficiency in BALB/c mice. We compared four nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U150), and a vibrating mesh nebulizer (NE-SM1). The enzymatic activity of dornase alfa was assessed using a kinetic fluorometric DNase activity assay. Both jet nebulizers had large residual volumes between 24% and 27%, while the volume of the NE-SM1 nebulizer was less than 2%. Evaluation of dornase alfa aerosols produced by the four nebulizers showed no overall loss of enzymatic activity or protein content and no increase in aggregation or degradation. The amount of dornase alfa delivered to the lungs was highest for the PARI BOY SX-red jet nebulizer. This result confirmed that aerosol droplet size is an important factor in determining the efficiency of dornase alfa delivery to the lungs. Further clinical studies and analysis are required before any conclusions can be drawn regarding the clinical safety and efficacy of these nebulizers.
Kyung Hwa Chang; Sang-Hyub Moon; Sun Kook Yoo; Bong Joo Park; Ki Chang Nam. Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics 2020, 12, 721 .
AMA StyleKyung Hwa Chang, Sang-Hyub Moon, Sun Kook Yoo, Bong Joo Park, Ki Chang Nam. Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers. Pharmaceutics. 2020; 12 (8):721.
Chicago/Turabian StyleKyung Hwa Chang; Sang-Hyub Moon; Sun Kook Yoo; Bong Joo Park; Ki Chang Nam. 2020. "Aerosol Delivery of Dornase Alfa Generated by Jet and Mesh Nebulizers." Pharmaceutics 12, no. 8: 721.
Various theragnostic agents have been devised and developed as cancer treatments; however, existing agents are often limited by their specific functions and complexities. Here, we report multifunctional magnetite (Fe3O4) nanoparticles functionalized with chlorin e6 (Ce6) and folic acid (FA) using a simple fabrication process to be used as theragnostic agents in photodynamic therapy (PDT). The effectiveness of cellular uptake of Fe3O4-Ce6-FA nanoparticles (FCF NPs) and its visualization as well as the photodynamic anticancer activities were evaluated. The mechanism of cancer cell death by the FCF NPs was also verified with qualitative and quantitative methods. Results indicate that FCF NPs have good penetration efficacy, resulting in excellent in vitro fluorescence and magnetic resonance imaging in cancer cells. FCF NPs exhibited promising anticancer activity in an irradiation time- and FCF NPs-dose-dependent manner in various cancer cell lines, leading to apoptotic cell death via morphological changes in cell membrane, nuclear, and DNA damage, and via overexpression of apoptosis-related genes, such as ZFP36L1, CYR61, GADD45G, caspases-2, -3, -9, 10, and -14. This study suggests that FCF NPs may be safely used in cancer therapy via PDT and could be a versatile therapeutic tool and biocompatible theragnostic agent, which may be used in diagnostic imaging.
Ki Chang Nam; Yong Soo Han; Jong-Min Lee; Si Chan Kim; Guangsup Cho; Bong Joo Park. Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics. Cancers 2020, 12, 571 .
AMA StyleKi Chang Nam, Yong Soo Han, Jong-Min Lee, Si Chan Kim, Guangsup Cho, Bong Joo Park. Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics. Cancers. 2020; 12 (3):571.
Chicago/Turabian StyleKi Chang Nam; Yong Soo Han; Jong-Min Lee; Si Chan Kim; Guangsup Cho; Bong Joo Park. 2020. "Photo-Functionalized Magnetic Nanoparticles as a Nanocarrier of Photodynamic Anticancer Agent for Biomedical Theragnostics." Cancers 12, no. 3: 571.
Recent reports using a breathing simulator system have suggested that mesh nebulizers provide more effective medication delivery than jet nebulizers. In this study, the performances of jet and mesh nebulizers were evaluated by comparing their aerosol drug delivery efficiencies in mice. We compared four home nebulizers: two jet nebulizers (PARI BOY SX with red and blue nozzles), a static mesh nebulizer (NE-U22), and a vibrating mesh nebulizer (NE-SM1). After mice were exposed to salbutamol aerosol, the levels of salbutamol in serum and lung were estimated by ELISA. The residual volume of salbutamol was the largest at 34.6% in PARI BOY SX, while the values for NE-U22 and NE-SM1 mesh nebulizers were each less than 1%. The salbutamol delivery efficiencies of NE-U22 and NE-SM1 were higher than that of PARI BOY SX, as the total delivered amounts of lung and serum were 39.9% and 141.7% as compared to PARI BOY SX, respectively. The delivery efficiency of the mesh nebulizer was better than that of the jet nebulizer. Although the jet nebulizer can generate smaller aerosol particles than the mesh nebulizer used in this study, the output rate of the jet nebulizer is low, resulting in lower salbutamol delivery efficiency. Therefore, clinical validation of the drug delivery efficiency according to nebulizer type is necessary to avoid overdose and reduced drug wastage.
Kyung Hwa Chang; Sang-Hyub Moon; Jin Young Oh; Young-Soon Yoon; Namyi Gu; Chi-Yeon Lim; Bong Joo Park; Ki Chang Nam. Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice. Pharmaceutics 2019, 11, 192 .
AMA StyleKyung Hwa Chang, Sang-Hyub Moon, Jin Young Oh, Young-Soon Yoon, Namyi Gu, Chi-Yeon Lim, Bong Joo Park, Ki Chang Nam. Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice. Pharmaceutics. 2019; 11 (4):192.
Chicago/Turabian StyleKyung Hwa Chang; Sang-Hyub Moon; Jin Young Oh; Young-Soon Yoon; Namyi Gu; Chi-Yeon Lim; Bong Joo Park; Ki Chang Nam. 2019. "Comparison of Salbutamol Delivery Efficiency for Jet versus Mesh Nebulizer Using Mice." Pharmaceutics 11, no. 4: 192.
Photodynamic therapy (PDT) is a promising alternative to conventional cancer treatment methods. Nonetheless, improvement of in vivo light penetration and cancer cell-targeting efficiency remain major challenges in clinical photodynamic therapy. This study aimed to develop multifunctional magnetic nanoparticles conjugated with a photosensitizer (PS) and cancer-targeting molecules via a simple surface modification process for PDT. To selectively target cancer cells and PDT functionality, core magnetic (Fe3O4) nanoparticles were covalently bound with chlorin e6 (Ce6) as a PS and folic acid (FA). When irradiated with a 660-nm long-wavelength light source, the Fe3O4-Ce6-FA nanoparticles with good biocompatibility exerted marked anticancer effects via apoptosis, as confirmed by analyzing the translocation of the plasma membrane, nuclear fragmentation, activities of caspase-3/7 in prostate (PC-3) and breast (MCF-7) cancer cells. Ce6, used herein as a PS, is thus more useful for PDT because of its ability to produce a high singlet oxygen quantum yield, which is owed to deep penetration by virtue of its long-wavelength absorption band; however, further in vivo studies are required to verify its biological effects for clinical applications.
Kyong-Hoon Choi; Ki Chang Nam; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells. Nanomaterials 2018, 8, 722 .
AMA StyleKyong-Hoon Choi, Ki Chang Nam, Guangsup Cho, Jin-Seung Jung, Bong Joo Park. Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells. Nanomaterials. 2018; 8 (9):722.
Chicago/Turabian StyleKyong-Hoon Choi; Ki Chang Nam; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. 2018. "Enhanced Photodynamic Anticancer Activities of Multifunctional Magnetic Nanoparticles (Fe3O4) Conjugated with Chlorin e6 and Folic Acid in Prostate and Breast Cancer Cells." Nanomaterials 8, no. 9: 722.
Heterogeneous [email protected]@Au core-shell microspheres, a facile and highly efficient catalyst have been fabricated by a simple surface modification. The fabrication process involved the coating of TiO2 nanoshell onto the magnetic core using by sol-gel process, and then the anchoring of Au nanoparticles onto the surface of the [email protected] microspheres through the wet chemical reaction of 3-aminopropyltriethoxysilane (APTES). The as-synthesized [email protected] microspheres exhibited a narrow size distribution, with a typical size of 350 nm and shell thickness of 25 nm. The [email protected]@Au microspheres can be easily collected by applying external magnetic field due to the magnetic property of core Fe3O4 particles. Compared to unmodified [email protected] microspheres, the [email protected]@Au microspheres showed higher photocatalytic activity for 2, 4, 6-trichlorophenol (TCP). The photocatalytic efficiency of the [email protected] microspheres was 28% after 40 min irradiation while, the efficiency of [email protected]@Au microspheres was 98% at the same condition.
Kyong-Hoon Choi; JeeEun Min; So-Yeong Park; Bong Joo Park; Jin-Seung Jung. Enhanced photocatalytic degradation of tri-chlorophenol by [email protected]@Au photocatalyst under visible-light. Ceramics International 2018, 45, 9477 -9482.
AMA StyleKyong-Hoon Choi, JeeEun Min, So-Yeong Park, Bong Joo Park, Jin-Seung Jung. Enhanced photocatalytic degradation of tri-chlorophenol by [email protected]@Au photocatalyst under visible-light. Ceramics International. 2018; 45 (7):9477-9482.
Chicago/Turabian StyleKyong-Hoon Choi; JeeEun Min; So-Yeong Park; Bong Joo Park; Jin-Seung Jung. 2018. "Enhanced photocatalytic degradation of tri-chlorophenol by [email protected]@Au photocatalyst under visible-light." Ceramics International 45, no. 7: 9477-9482.
In the field of drug delivery, a nebulizer is a device used to convert liquid drugs into tiny airborne droplets, such as aerosol or a mist form. These fine droplets are delivered to a patient’s lungs and airways and then spread throughout the body via blood vessels. Therefore, nebulization therapy is a highly-effective method compared with existing drug delivery methods. To enhance the curative influence of a drug, this study suggests the use of a new micro-porous mesh nebulizer consisting of a controllable palladium–nickel (Pd–Ni) membrane filter, piezoelectric element, and a cavity in the micro-pump. In this research, we optimize a biocompatible Pd–Ni membrane filter, such that it generated the smallest aerosol particles of various drugs. The pore size of the filter outlet is 4.2 μm ± 0.15 μm and the thickness of the Pd-Ni membrane filter is approximately 41.5 μm. In addition, the Pd–Ni membrane filter has good biocompatibility with normal cells. The result of a spray test with deionized (DI) water indicated that the size of a standard liquid droplet is 4.53 μm. The device has an electrical requirement, with a low power consumption of 2.5 W, and an optimal operation frequency of 98.5 kHz.
Kyong-Hoon Choi; Sang-Hyub Moon; Su-Kang Park; Guangsup Cho; Ki Chang Nam; Bong Joo Park. Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery. Applied Sciences 2018, 8, 604 .
AMA StyleKyong-Hoon Choi, Sang-Hyub Moon, Su-Kang Park, Guangsup Cho, Ki Chang Nam, Bong Joo Park. Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery. Applied Sciences. 2018; 8 (4):604.
Chicago/Turabian StyleKyong-Hoon Choi; Sang-Hyub Moon; Su-Kang Park; Guangsup Cho; Ki Chang Nam; Bong Joo Park. 2018. "Fabrication and Characterization of Medical Mesh-Nebulizer for Aerosol Drug Delivery." Applied Sciences 8, no. 4: 604.
A plasma pad that can be attached to human skin was developed for aesthetic and dermatological treatment. A polyimide film was used for the dielectric layer of the flexible pad, and high-voltage and ground electrodes were placed on the film surface. Medical gauze covered the ground electrodes and was placed facing the skin to act as a spacer; thus, the plasma floated between the gauze and ground electrodes. In vitro and in vivo biocompatibility tests of the pad showed no cytotoxicity to normal cells and no irritation of mouse skin. Antibacterial activity was shown against Staphylococcus aureus and clinical isolates of methicillin-resistant S. aureus. Furthermore, skin wound healing with increased hair growth resulting from increased exogenous nitric oxide and capillary tube formation induced by the plasma pad was also confirmed in vivo. The present study suggests that this flexible and wearable plasma pad can be used for biomedical applications such as treatment of wounds and bacterial infections.
Junggil Kim; Kyong-Hoon Choi; Yunjung Kim; Bong Joo Park; Guangsup Cho. Wearable Plasma Pads for Biomedical Applications. Applied Sciences 2017, 7, 1308 .
AMA StyleJunggil Kim, Kyong-Hoon Choi, Yunjung Kim, Bong Joo Park, Guangsup Cho. Wearable Plasma Pads for Biomedical Applications. Applied Sciences. 2017; 7 (12):1308.
Chicago/Turabian StyleJunggil Kim; Kyong-Hoon Choi; Yunjung Kim; Bong Joo Park; Guangsup Cho. 2017. "Wearable Plasma Pads for Biomedical Applications." Applied Sciences 7, no. 12: 1308.
In this study, we report a new multifunctional nanoparticle with antioxidative and antibacterial activities in vitro. [email protected] nanoparticles were fabricated by coordinated covalent bonding of the antioxidant gallic acid (GA) on the surface of ZnO nanoparticles. This addition imparts both antioxidant activity and high affinity for the bacterial cell membrane. Antioxidative activities at various concentrations were evaluated using a 2,2′-azino-bis(ethylbenzthiazoline-6-sulfonic acid) (ABTS) radical scavenging method. Antibacterial activities were evaluated against Gram-positive bacteria (Staphylococcus aureus: S. aureus), including several strains of methicillin-resistant S. aureus (MRSA), and Gram-negative bacteria (Escherichia coli). The functionalized [email protected] nanoparticles showed good antioxidative activity (69.71%), and the bactericidal activity of these nanoparticles was also increased compared to that of non-functionalized ZnO nanoparticles, with particularly effective inhibition and high selectivity for MRSA strains. The results indicate that multifunctional ZnO nanoparticles conjugated to GA molecules via a simple surface modification process displaying both antioxidant and antibacterial activity, suggesting a possibility to use it as an antibacterial agent for removing MRSA.
Joo Min Lee; Kyong-Hoon Choi; JeeEun Min; Ho-Joong Kim; Jun-Pil Jee; Bong Joo Park. Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. Nanomaterials 2017, 7, 365 .
AMA StyleJoo Min Lee, Kyong-Hoon Choi, JeeEun Min, Ho-Joong Kim, Jun-Pil Jee, Bong Joo Park. Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus. Nanomaterials. 2017; 7 (11):365.
Chicago/Turabian StyleJoo Min Lee; Kyong-Hoon Choi; JeeEun Min; Ho-Joong Kim; Jun-Pil Jee; Bong Joo Park. 2017. "Functionalized ZnO Nanoparticles with Gallic Acid for Antioxidant and Antibacterial Activity against Methicillin-Resistant S. aureus." Nanomaterials 7, no. 11: 365.
We report a novel zinc oxide (ZnO) nanoparticle with antioxidant properties, prepared by immobilizing the antioxidant 3-(3,4-dihydroxyphenyl)-2-propenoic acid (caffeic acid, CA) on the surfaces of micro-dielectric barrier discharge (DBD) plasma-treated ZnO nanoparticles. The microstructure and physical properties of [email protected] nanoparticles were characterized by field emission scanning electron microscopy (FESEM), transmission electron microscopy (TEM), infrared spectroscopy, and steady state spectroscopic methods. The antioxidant activity of [email protected] nanoparticles was evaluated using an ABTS (3-ethyl-benzothiazoline-6-sulfonic acid) radical cation decolorization assay. [email protected] nanoparticles exhibited robust antioxidant activity. Moreover, [email protected] nanoparticles showed strong antibacterial activity against Gram-positive bacteria (Staphylococcus aureus) including resistant bacteria such as methicillin-resistant S. aureus and against Gram-negative bacteria (Escherichia coli). Although Gram-negative bacteria appeared to be more resistant to [email protected] nanoparticles than Gram-positive bacteria, the antibacterial activity of [email protected] nanoparticles was dependent on particle concentration. The antioxidant and antibacterial activity of [email protected] may be useful for various biomedical and nanoindustrial applications.
Kyong-Hoon Choi; Ki Chang Nam; Sang-Yoon Lee; Guangsup Cho; Jin-Seung Jung; Ho-Joong Kim; Bong Joo Park. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials 2017, 7, 148 .
AMA StyleKyong-Hoon Choi, Ki Chang Nam, Sang-Yoon Lee, Guangsup Cho, Jin-Seung Jung, Ho-Joong Kim, Bong Joo Park. Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles. Nanomaterials. 2017; 7 (6):148.
Chicago/Turabian StyleKyong-Hoon Choi; Ki Chang Nam; Sang-Yoon Lee; Guangsup Cho; Jin-Seung Jung; Ho-Joong Kim; Bong Joo Park. 2017. "Antioxidant Potential and Antibacterial Efficiency of Caffeic Acid-Functionalized ZnO Nanoparticles." Nanomaterials 7, no. 6: 148.
Photodynamic therapy (PDT) has been adopted as a minimally invasive approach for the localized treatment of superficial tumors, representing an improvement in the care of cancer patients. To improve the efficacy of PDT, it is important to first select an optimized nanocarrier and determine the influence of light parameters on the photosensitizing agent. In particular, much more knowledge concerning the importance of fluence and exposure time is required to gain a better understanding of the photodynamic efficacy. In the present study, we synthesized novel folic acid-(FA) and hematoporphyrin (HP)-conjugated multifunctional magnetic nanoparticles (CoFe2O4-HPs-FAs), which were characterized as effective anticancer reagents for PDT, and evaluated the influence of incubation time and light exposure time on the photodynamic anticancer activities of CoFe2O4-HPs-FAs in prostate cancer cells (PC-3 cells). The results indicated that the same fluence at different exposure times resulted in changes in the anticancer activities on PC-3 cells as well as in reactive oxygen species formation. In addition, an increase of the fluence showed an improvement for cell photo-inactivation. Therefore, we have established optimized conditions for new multifunctional magnetic nanoparticles with direct application for improving PDT for cancer patients.
Kyong-Hoon Choi; Ki Chang Nam; Un-Ho Kim; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles. Nanomaterials 2017, 7, 144 .
AMA StyleKyong-Hoon Choi, Ki Chang Nam, Un-Ho Kim, Guangsup Cho, Jin-Seung Jung, Bong Joo Park. Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles. Nanomaterials. 2017; 7 (6):144.
Chicago/Turabian StyleKyong-Hoon Choi; Ki Chang Nam; Un-Ho Kim; Guangsup Cho; Jin-Seung Jung; Bong Joo Park. 2017. "Optimized Photodynamic Therapy with Multifunctional Cobalt Magnetic Nanoparticles." Nanomaterials 7, no. 6: 144.
In this study, newly designed biocompatible multifunctional magnetic submicron particles (CoFe2O4-HPs-FAs) of well-defined sizes (60, 133, 245, and 335 nm) were fabricated for application as a photosensitizer delivery agent for photodynamic therapy in cancer cells. To provide selective targeting of cancer cells and destruction of cancer cell functionality, basic cobalt ferrite (CoFe2O4) particles were covalently bonded with a photosensitizer (PS), which comprises hematoporphyrin (HP), and folic acid (FA) molecules. The magnetic properties of the CoFe2O4 particles were finely adjusted by controlling the size of the primary CoFe2O4 nanograins, and secondary superstructured composite particles were formed by aggregation of the nanograins. The prepared CoFe2O4-HP-FA exhibited high water solubility, good MR-imaging capacity, and biocompatibility without any in vitro cytotoxicity. In particular, our CoFe2O4-HP-FA exhibited remarkable photodynamic anticancer efficiency via induction of apoptotic death in PC-3 prostate cancer cells in a particle size- and concentration-dependent manner. This size-dependent effect was determined by the specific surface area of the particles because the number of HP molecules increased with decreasing size and increasing surface area. These results indicate that our CoFe2O4-HP-FA may be applicable for photodynamic therapy (PDT) as a PS delivery material and a therapeutic agent for MR-imaging based PDT owing to their high saturation value for magnetization and superparamagnetism.
Kyong-Hoon Choi; Ki Chang Nam; Leszek Malkinski; Eun Ha Choi; Jin-Seung Jung; Bong Joo Park. Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells. Molecules 2016, 21, 1187 .
AMA StyleKyong-Hoon Choi, Ki Chang Nam, Leszek Malkinski, Eun Ha Choi, Jin-Seung Jung, Bong Joo Park. Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells. Molecules. 2016; 21 (9):1187.
Chicago/Turabian StyleKyong-Hoon Choi; Ki Chang Nam; Leszek Malkinski; Eun Ha Choi; Jin-Seung Jung; Bong Joo Park. 2016. "Size-Dependent Photodynamic Anticancer Activity of Biocompatible Multifunctional Magnetic Submicron Particles in Prostate Cancer Cells." Molecules 21, no. 9: 1187.
Titanium is a well proven implantable material especially for osseointegratable implants by its biocompatibility and anti-corrosive surface properties. Surface characteristics of the implant play an important role for the evolution of bone tissue of the recipient site. Among the various surface modification methods, plasma treatment is one of the promising methods for enhance biocompatibility. We made microwave-induced argon plasma at atmospheric pressure to improve in titanium surface biocompatibility. Various states of emission spectra from excited species-argon, nitrogen atoms and oxygen atoms were observed. The electron energy band structures are the unique characteristics of atoms and functional groups. Microwave-induced argon plasma treatment changed the titanium surface to be very hydrophilic especially on the 5 s short treatment and 30 s, 90 s long treatment samples that detected by contact angle measurement. MC3T3-E1 attachment and proliferation assay significantly increased in 5 s at short treatment, 30 s, and 90 s at long treatment after 5 days incubation. Result indicated that microwave-induce argon plasma treatment would be an effective method to modify titanium surface for enhancing cell-material interactions.
Gyeung Mi Seon; Hyok Jin Seo; Soon Young Kwon; Mi Hee Lee; Byeong-Ju Kwon; Min Sung Kim; Min-Ah Koo; Bong Joo Park; Jong-Chul Park. Titanium surface modification by using microwave-induced argon plasma in various conditions to enhance osteoblast biocompatibility. Biomaterials Research 2015, 19, 1 -7.
AMA StyleGyeung Mi Seon, Hyok Jin Seo, Soon Young Kwon, Mi Hee Lee, Byeong-Ju Kwon, Min Sung Kim, Min-Ah Koo, Bong Joo Park, Jong-Chul Park. Titanium surface modification by using microwave-induced argon plasma in various conditions to enhance osteoblast biocompatibility. Biomaterials Research. 2015; 19 (1):1-7.
Chicago/Turabian StyleGyeung Mi Seon; Hyok Jin Seo; Soon Young Kwon; Mi Hee Lee; Byeong-Ju Kwon; Min Sung Kim; Min-Ah Koo; Bong Joo Park; Jong-Chul Park. 2015. "Titanium surface modification by using microwave-induced argon plasma in various conditions to enhance osteoblast biocompatibility." Biomaterials Research 19, no. 1: 1-7.
Nowadays, photodynamic therapy (PDT) is a quite promising approach for killing various cancer cells. In this work, we report on photo-functional magnetic nanoparticles conjugated with hematoporphyrin (HP) ([email protected]) via a simple surface modification process. The microstructure and the magnetic properties of the Fe3O4 nanoparticles were investigated by field emission scanning electron microscopy (FE-SEM), transmission electron microscopy (TEM), X-ray diffraction (XRD), energy dispersive spectroscopy (EDS), and vibrating sample magnetometry (VSM), and the biocompatibility and the photo-killing activity were evaluated using mammalian cells in vitro to confirm the potential of these particles for use as an agent for PDT application. We have demonstrated that the [email protected] nanoparticles show good biocompatibilities in fibroblast (L-929) and prostate cancer (PC-3) cells and have remarkable photodynamic anticancer activities. Especially, the photo-killing activities for 25, 50, and 100 μg/ml of [email protected] were found to be above 86% (86.6, 99.2, and 99.4%, respectively) in PC-3 cells, demonstrating significantly high anticancer effects on prostate cancer cells, these effects depend on the concentration of the [email protected] nanoparticles. These results indicate that our [email protected] nanoparticles can be useful for PDT, although further studies to evaluate the cell-death mechanisms in vitro and in vivo will be needed to verify the potential for clinical PDT applications.
Kyong-Hoon Choi; Ki Chang Nam; Ho-Joong Kim; JeeEun Min; Han Sup Uhm; Eun Ha Choi; Bong Joo Park; Jin-Seung Jung. Synthesis and characterization of photo-functional magnetic nanoparticles ([email protected]) for applications in photodynamic cancer therapy. Journal of the Korean Physical Society 2014, 65, 1658 -1662.
AMA StyleKyong-Hoon Choi, Ki Chang Nam, Ho-Joong Kim, JeeEun Min, Han Sup Uhm, Eun Ha Choi, Bong Joo Park, Jin-Seung Jung. Synthesis and characterization of photo-functional magnetic nanoparticles ([email protected]) for applications in photodynamic cancer therapy. Journal of the Korean Physical Society. 2014; 65 (10):1658-1662.
Chicago/Turabian StyleKyong-Hoon Choi; Ki Chang Nam; Ho-Joong Kim; JeeEun Min; Han Sup Uhm; Eun Ha Choi; Bong Joo Park; Jin-Seung Jung. 2014. "Synthesis and characterization of photo-functional magnetic nanoparticles ([email protected]) for applications in photodynamic cancer therapy." Journal of the Korean Physical Society 65, no. 10: 1658-1662.