Background. Early and accurate evaluation of severity and prognosis in acute pancreatitis (AP), especially at the time of admission is very significant. This study was aimed to develop an artificial neural networks (ANN) model for early prediction of in‐hospital mortality in AP. Methods. Patients with AP were identified from the Medical Information Mart for Intensive Care‐III (MIMIC‐III) database. Clinical and laboratory data were utilized to perform a predictive model by back propagation ANN approach. Results. A total of 337 patients with AP were analyzed in the study, and the in‐hospital mortality rate was 11.2%. A total of 12 variables that differed between patients in survivor group and nonsurvivor group were applied to construct ANN model. Three independent variables were identified as risk factors associated with in‐hospital mortality by multivariate logistic regression analysis. The predictive performance based on the area under the receiver operating characteristic curve (AUC) was 0.769 for ANN model, 0.607 for logistic regression, 0.652 for Ranson score, and 0.401 for SOFA score. Conclusion. An ANN predictive model for in‐hospital mortality in patients with AP in MIMIC‐III database was first performed. The patients with high risk of fatal outcome can be screened out easily in the early stage of AP by our model.

Objective: Clinical manifestations and histological lesions of IgA nephropathy are variable and correlate with the renal outcome of the patient. The aim of the present study is to clarify the clinicopathological features and the prognosis of patients with IgA nephropathy presenting with dominant diffuse endocapillary proliferative lesions. Methods: The morphological and clinical features of 126 patients with and without diffuse endocapillary proliferation were compared. 29 out of 126 are IgA nephritis patients with diffuse endocapillary proliferation. The others are patients without diffuse endocapillary proliferation. The prognosis of the patients in the 2 groups was analyzed and the effects of diffuse endocapillary proliferation on renal progression in patients with different renal function were also analyzed. Results: Patients with diffuse endocapillary proliferation show significantly higher proteinuria (p < 0.0001) and crescent percent (p < 0.05). There is no significant difference of renal survival in patients with or without diffuse endocapillary proliferation. Further analysis indicated that patients with diffuse endocapillary proliferation had better renal survival than those without it (log rank, p = 0.0561) if their renal function was normal, whereas renal survival of patients with diffuse endocapillary proliferation was worse than of those without it if their renal function was abnormal (log rank, p = 0.0763). Conclusion: IgA nephropathy with diffuse endocapillary proliferation shows a better prognosis in the patients with normal renal function, but it is a relative risk factor for end-stage renal disease in patients with abnormal renal function.

Background. Triglyceride/high‐density lipoprotein cholesterol (TG/HDL‐c) ratio varies with vascular and other metabolic diseases. However, its role in acute type B aortic dissection is not well understood. In the current study, we evaluated the relationship between TG/HDL‐c ratio and in‐hospital mortality in type B aortic dissection. Methods. We performed a retrospective analysis of consecutive patients between January 2015 and December 2018, by targeting dependent (TG/HDL‐c ratio) and independent (in‐hospital mortality) variables. TG/HDL‐c ratio was determined as a division of TG levels by HDL‐c levels. Results. Of 523 patients in the study, we found a mean age of 55.00 ± 11.74 years, 15.68% of them being female. A fully‐adjusted model revealed a positive relationship between TG/HDL‐c ratio and in‐hospital mortality in acute type B aortic dissection after adjusting confounders (OR = 2.08, 95% CI 1.32 to 3.27). This relationship was also nonlinear, with a point of 2.05. OR values (and confidence intervals) for the right (>2.05) and left (≤2.05) sides of the inflection point were 1.0 (0.580‐1.26, P = 0.983) and 3.17 (1.54‐6.57, P = 0.001), respectively. Conclusions. The TG/HDL‐c ratio and in‐hospital mortality in type B AAD have a nonlinear relationship among Chinese population. This ratio increased in‐hospital mortality when it is less than 2.05.