The aim of this review article was to summarize the functional implications of the nuclear factor E2-related factor or nuclear factor (erythroid-derived 2)-like 2 (Nrf2), with special attention to the NACHT (nucleotide-binding oligomerization), LRR (leucine-rich repeat), and PYD (pyrin domain) domains-containing protein 3 (NLRP3) inflammasome in the field of dentistry. NLRP3 plays a crucial role in the progression of inflammatory and adaptive immune responses throughout the body. It is already known that this inflammasome is a key regulator of several systemic diseases. The initiation and activation of NLRP3 starts with the oral microbiome and its association with the pathogenesis and progression of several oral diseases, including periodontitis, periapical periodontitis, and oral squamous cell carcinoma (OSCC). The possible role of the inflammasome in oral disease conditions may involve the aberrant regulation of various response mechanisms, not only in the mouth but in the whole body. Understanding the cellular and molecular biology of the NLRP3 inflammasome and its relationship to Nrf2 is necessary for the rationale when suggesting it as a potential therapeutic target for treatment and prevention of oral inflammatory and immunological disorders. In this review, we highlighted the current knowledge about NLRP3, its likely role in the pathogenesis of various inflammatory oral processes, and its crosstalk with Nrf2, which might offer future possibilities for disease prevention and targeted therapy in the field of dentistry and oral health.

Objectives: Anterior crowding in the lower jaw is a common orthodontic issue often managed through premolar extraction, which can affect facial profile development. This study aimed to evaluate skeletal and dental changes in moderate to severe crowding using a novel mandibular reference line—the Ramus Anterior Vertical (RaV)—to support treatment planning. Methods: A total of 140 patients (LII > 4 mm and < 9 mm; mean age ≈ 12.5 years) were divided into two groups (G1: extraction; G2: nonextraction; total n = 140; n = 70 per group). Skeletal and dental parameters were measured before (T0) and after (T1) orthodontic treatment using 280 lateral cephalograms. RaV was defined as a vertical line through the anterior ramus point, perpendicular to the occlusal plane. Results: Sagittal measurements relative to RaV were reproducible and unaffected by mandibular mobility. Significant vertical skeletal changes were observed in G2 females, with an increased anterior facial height (N–Sp′ and Sp′–Gn) but a stable Hasund Index. In G1, the dental arch length and distances from RaV to i5 and i6 were reduced, while second molars (i7) remained stable. Sagittal incisor axis changes (L1–NB°, SAi1°) and skeletal–dental correlations (ML–NSL, Gn–tGo–Ar) were present only in G1. Conclusions: RaV proved to be a stable mandibular reference for assessing treatment effects. In this study, premolar extraction vs. nonextraction was comparably effective, though some vertical skeletal adaptations, especially in G2 females, took place.

Objectives: Simplifying interdental space cleaning is a constantly discussed topic. The present study aimed to compare the cleansing efficacy of an oral irrigator with that of dental flossing in adolescent patients with fixed braces after four weeks of home-use. Materials and methods: The study design is a randomized, single-blinded cross-over study. Following a twenty-eight-day period of product utilization in a home setting, a comparative analysis was conducted on hygiene indices, the Rustogi Modified Navy Plaque Index (RMNPI) and the Gingival Bleeding Index (GBI), between the test group (oral irrigator) and the control group (dental floss). Results: Seventeen adolescent individuals completed the study. After 28 days of cleaning with the oral irrigator, RMNPI was 58.81% (55.31–66.47) compared to 59.46% (52.68–68.67) with dental floss (p = 0.070). Subgroup analyses did not indicate the superiority of either method. GBI after the test phase with the oral irrigator was 28.93% (23.21–33.97) and insignificantly higher compared to 26.40% (21.01–31.41) achieved with dental floss (p = 0.1585). Conclusions: Neither of the two products demonstrated statistically significant superiority in terms of cleaning efficacy. Therefore, no recommendation can be made in favor of one over the other. It was found that the high initial hygiene indices for fixed orthodontic appliances could be improved through increased awareness and precise instruction. Clinical relevance: For adolescent patients who struggle to use interdental brushes an oral irrigator may be suggested as a simple alternative in hard-to-reach areas, such as those around a fixed dental appliance.

Purpose: This study investigates the accuracy of abutment transfer with current impression materials and provides a concise overview, including other relevant factors, in order to enable clinicians to make an informed decision about the optimal impression for this treatment procedure. Methods: In all, 96 impressions of a cadaver head with two orthodontic miniscrews in place were taken with four common impression materials by two observers and using two methods of application. After pouring with a standard type IV stone and abutment transfer, all models and the upper jaw (which had been separated from the head) were scanned in a standard model scanner (Zirkonzahn® [Zirkohnzahn GmbH, Gais, Italy] S600 ARTI) and evaluated using a computer-aided design (CAD) program (GOM-Inspect [Gesellschaft für optische Messtechnik m.b.H., Braunschweig, Germany]). The deviations were measured at six points per screw and statistically evaluated with SPSS® (IBM, Chicago, IL, USA). Results: Optimal values were obtained with biphasic polyvinylsiloxane, while monophasic polyvinylsiloxane, alginate and polyether also resulted in acceptable accuracy. Observer experience showed no effect and the method of application had only a minor effect on accuracy. Conclusions: Within the limitations of this study, it seems that all impression materials are suitable for miniscrew abutment transfer, provided that methods of intraoral adaptation of the orthodontic appliance can be employed. If higher accuracy is needed or for clinicians with less experienced, a biphasic polyvinylsiloxane impression with the putty-wash technique should be used as this combination reduces setting time. The most cost-effective version, alginate, can be used if the consequences of greater deviations can be handled. Caution is advised with polyether if undercuts are present.

Background: We investigated the relationship between the mandibular Curve of Spee (COS) and a persisting primary second mandibular molar (ppM2) due to an agenesis of the second mandibular premolar, using a digital software technique. Methods: Digital dental casts were obtained from 200 patients at the Department of Orthodontics in Innsbruck and Vienna, Austria. Patients (age-, gender-, and malocclusion-matched) were equally divided into two groups (n = 100) according to the existence of a ppM2. COS depth, overjet, overbite, and angle-classification were measured digitally using the OnyxCeph3^TM (version 3.2.147) software. ANOVA and Kruskal–Wallis tests were used to analyze relationships. For statistical analyses, p < 0.05 was considered as statistically significant, p < 0.01 as highly significant. Results were visualized with box plots and bar charts. Results: The deepest COS was present in patients with a ppM2. Furthermore, a positive correlation was shown between COS depth and angle-class II, between COS depth and age, as well as between COS depth and overbite. No gender differences could be observed. Conclusions: In our study population the COS depth was dependent on whether there is a ppM2 due to an agenesis of a second mandibular premolar or not, as well as on the malocclusion in sagittal direction.