The aim of this paper is to investigate whether existing generic fragility curves for various residential building typologies can be safely applied for the vulnerability assessment of school buildings. We select three representative typologies of actual reinforced concrete (RC) school buildings in Thessaloniki, Greece and we conduct a detailed fragility analysis combining field inspection and structural monitoring data to advanced numerical modeling. Building-specific fragility and vulnerability curves are derived for the three school buildings based on 3D incremental dynamic analysis (IDA) of the calibrated numerical models. The comparisons of the developed curves with generic ones showed their significant differences.