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Prof. Dr. Adel Kadri
Faculty of Science and Arts in Baljurashi, Albaha University, P.O. Box 1988, Albaha postcode, Saudi Arabia

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0 molecular docking
0 bioactive compounds
0 ADMET prediction
0 In silico methods

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Full paper
Published: 17 August 2021 in ChemistrySelect
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In our attempt to develop potential new drug candidates with promising dual antimicrobial and anticancer activities, a series of pyrazolothiazole and thiazolopyridine analogues has been synthesized. All compounds were evaluated for their antimicrobial potential towards pathogenic strains and cytotoxicity properties against hepatic cancer cell line HepG-2 and breast cancer cell line MCF-7. 9 c showed excellent antimicrobial activity against the tested strains, with MIC values about 27.5 μM (S. epidermidis), 6.8 (B. subtilis) and 3.4 μM (S. pneumoniae and K. pneumoniae) fold higher than the reference drug, whilst 9 a, 9 b and 5 a exhibited also potent activity against selected strains. Moreover, compounds 9 c (IC50=10.89 μM and 15.60 μM) and 9 a (IC50=22.24 μM and 28.47 μM) showed promising anticancer activity for HepG2 and MCF-7 cell lines, respectively, when compared to the known anticancer drugs, 5-Fluorouracil (IC50=26.75 μM and IC50=32.75 μM). The data from structure-activity relationships analysis revealed the potency of pyrazolothiazole than thiazolopyridine derivatives in generating potential activity. Further, molecular docking studies performed on the more active antimicrobial and cytotoxic compound, 9 c to get insights for binding modes to the target enzymes (PDB ID: 1JIJ) for antimicrobial, and (PDB ID: 1DI8) and (PDB ID: 3TWJ) for anticancer revealed that they interacted with the same key amino acids with TyrRS for S. aureus, CDK2 and ROCK1, respectively.

ACS Style

Ismail M. M. Othman; Mohamed A. M. Gad‐Elkareem; Hyam A. Radwan; Riadh Badraoui; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents. ChemistrySelect 2021, 6, 7860 -7872.

AMA Style

Ismail M. M. Othman, Mohamed A. M. Gad‐Elkareem, Hyam A. Radwan, Riadh Badraoui, Kaïss Aouadi, Mejdi Snoussi, Adel Kadri. Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents. ChemistrySelect. 2021; 6 (31):7860-7872.

Chicago/Turabian Style

Ismail M. M. Othman; Mohamed A. M. Gad‐Elkareem; Hyam A. Radwan; Riadh Badraoui; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. 2021. "Synthesis, Structure‐Activity Relationship and in silico Studies of Novel Pyrazolothiazole and Thiazolopyridine Derivatives as Prospective Antimicrobial and Anticancer Agents." ChemistrySelect 6, no. 31: 7860-7872.

Journal article
Published: 16 August 2021 in International Journal of Environmental Research and Public Health
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The COVID-19 pandemic has affected many societies’ life aspects and activities including social and Islamic practices; more attention should be given to investigate the interaction between Islamic worships and the spread of the disease. Here, we performed a cross-sectional study using an online questionnaire to assess the preventive Islamic attitudes and practices during the COVID-19 lockdown period from the Saudi publics’ perspectives. Mann-Whitney, Kruskal and logistic regression tests were used to analyze the data. The results revealed that most participants had positive Islamic attitudes and practices. However, elders and males were less obeyed to preventive measures during performing worship (p< 0.05). While younger, females and not married were less obeyed when dealing with COVID-19 related death (p< 0.05). Even though, elders were less likely to have poor social and Islamic practices concerning adherence to preventive measures during the pandemic (OR = 0.38; 95% CI: 0.176–0.816) than younger. Furthermore, males, Saudi participants, lower education level, lower Islamic attitudes scores were more likely to have poor social and Islamic practices concerning adherence to preventive measures during the pandemic (OR = 1.65; 95% CI: 1.126–2.421; OR = 1.57; 95% CI: 1.067–2.322; OR = 3.09; 95% CI: 1.721–5.563; and OR = 1.89; 95% CI: 1.309–2.753, respectively), than their corresponding targeted counterparts. Thus, despite the high preventative perceptions of Islamic attitudes and practices of the Saudi community, our study highlighted some risk groups with less preventative practices. Thus, targeted health education interventions are highly recommended for these risk groups to enhance the commitment to government instructions.

ACS Style

Fahad D. Algahtani; Mohamed Ali Alzain; Najoua Haouas; Khadijah Angawi; Bandar Alsaif; Adel Kadri; Mohamed A. Dkhil; Mejdi Snoussi; Rafat Zrieq. Coping during COVID-19 Pandemic in Saudi Community: Religious Attitudes, Practices and Associated Factors. International Journal of Environmental Research and Public Health 2021, 18, 8651 .

AMA Style

Fahad D. Algahtani, Mohamed Ali Alzain, Najoua Haouas, Khadijah Angawi, Bandar Alsaif, Adel Kadri, Mohamed A. Dkhil, Mejdi Snoussi, Rafat Zrieq. Coping during COVID-19 Pandemic in Saudi Community: Religious Attitudes, Practices and Associated Factors. International Journal of Environmental Research and Public Health. 2021; 18 (16):8651.

Chicago/Turabian Style

Fahad D. Algahtani; Mohamed Ali Alzain; Najoua Haouas; Khadijah Angawi; Bandar Alsaif; Adel Kadri; Mohamed A. Dkhil; Mejdi Snoussi; Rafat Zrieq. 2021. "Coping during COVID-19 Pandemic in Saudi Community: Religious Attitudes, Practices and Associated Factors." International Journal of Environmental Research and Public Health 18, no. 16: 8651.

Journal article
Published: 13 June 2021 in Molecules
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Herbs and spices have been used since antiquity for their nutritional and health properties, as well as in traditional remedies for the prevention and treatment of many diseases. Therefore, this study aims to perform a chemical analysis of both essential oils (EOs) from the seeds of Carum carvi (C. carvi) and Coriandrum sativum (C. sativum) and evaluate their antioxidant, antimicrobial, anti-acetylcholinesterase, and antidiabetic activities alone and in combination. Results showed that the EOs mainly constitute monoterpenes with γ-terpinene (31.03%), β-pinene (18.77%), p-cymene (17.16%), and carvone (12.20%) being the major components present in C. carvi EO and linalool (76.41%), γ-terpinene (5.35%), and α-pinene (4.44%) in C. sativum EO. In comparison to standards, statistical analysis revealed that C. carvi EO showed high and significantly different (p< 0.05) antioxidant activity than C. sativum EO, but lower than the mixture. Moreover, the mixture exhibited two-times greater ferric ion reducing antioxidant power (FRAP) (IC50 = 11.33 ± 1.53 mg/mL) and equipotent chelating power (IC50 = 31.33 ± 0.47 mg/mL) than the corresponding references, and also potent activity against 2,2-diphenyl-1-picrylhydrazyl (DPPH) (IC50 = 19.00 ± 1.00 mg/mL), β-carotene (IC50 = 11.16 ± 0.84 mg/mL), and superoxide anion (IC50 = 10.33 ± 0.58 mg/mL) assays. Antimicrobial data revealed that single and mixture EOs were active against a panel of pathogenic microorganisms, and the mixture had the ability to kill more bacterial strains than each EO alone. Additionally, the anti-acetylcholinesterase and α-glucosidase inhibitory effect have been studied for the first time, highlighting the high inhibition effect of AChE by C. carvi (IC50 = 0.82 ± 0.05 mg/mL), and especially by C. sativum (IC50 = 0.68 ± 0.03 mg/mL), as well as the mixture (IC50 = 0.63 ± 0.02 mg/mL) compared to the reference drug, which are insignificantly different (p > 0.05). A high and equipotent antidiabetic activity was observed for the mixture (IC50 = 0.75 ± 0.15 mg/mL) when compared to the standard drug, acarbose, which is about nine times higher than each EO alone. Furthermore, pharmacokinetic analysis provides some useful insights into designing new drugs with favorable drug likeness and safety profiles based on a C. carvi and C. sativum EO mixture. In summary, the results of this study revealed that the combination of these EOs may be recommended for further food, therapeutic, and pharmaceutical applications, and can be utilized as medicine to inhibit several diseases.

ACS Style

Hafedh Hajlaoui; Soumaya Arraouadi; Emira Noumi; Kaïss Aouadi; Mohd Adnan; Mushtaq Khan; Adel Kadri; Mejdi Snoussi. Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination. Molecules 2021, 26, 3625 .

AMA Style

Hafedh Hajlaoui, Soumaya Arraouadi, Emira Noumi, Kaïss Aouadi, Mohd Adnan, Mushtaq Khan, Adel Kadri, Mejdi Snoussi. Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination. Molecules. 2021; 26 (12):3625.

Chicago/Turabian Style

Hafedh Hajlaoui; Soumaya Arraouadi; Emira Noumi; Kaïss Aouadi; Mohd Adnan; Mushtaq Khan; Adel Kadri; Mejdi Snoussi. 2021. "Antimicrobial, Antioxidant, Anti-Acetylcholinesterase, Antidiabetic, and Pharmacokinetic Properties of Carum carvi L. and Coriandrum sativum L. Essential Oils Alone and in Combination." Molecules 26, no. 12: 3625.

Journal article
Published: 10 June 2021 in Journal of Molecular Structure
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To find out effective new antibacterial agents, a series of novel aryl-hydrazothiazolyl-sulfonamide derivatives 3a-e were synthesized and well characterized by analytical and spectroscopic techniques. All the compounds were evaluated for their antibacterial and antifungal potential and the results showed excellent antimicrobial activity of 3d against all strains, especially B. cereus (MIC = 5.54 μM vs. 17.6 μM), P. aeruginosa (MIC = 7.3 μM vs.12.8 μM), E. coli (MIC = 6.4 μM vs. 21.3 μM) and C. albicans (MIC = 6.8 μM vs. 26.4 μM) in comparison to the commercial antibiotics, tetracycline and amphotericin B, respectively. The others analogues dispalyed potent to moderate antimicrobial activity. Structure-activity relationships (SARs) provides specially that incorporation of pyrimidin-2-ylsulfamoyl group at the para-phenyl position (3d) is good contributor for improving the antimicrobial activity. Further, Density Functional Theory (DFT) on 3d revealed its high stability and strongest electron-donating capability. Molecular docking and dynamic simulation studies on 3d inside the active site of S. aureus tyrosyl-tRNA synthetase (PDB ID: 1JIJ), E. coli dihydropteroate synthetase (PDB ID: 1AJ0), C. albicans dihydropteroate synthetase (PDB ID: 4HOE), and C. albicans N-myristoyl transferase (PDB ID: 1IYL) showed good binding profiles with the targets proteins, in particular with 1IYL and 4HOE receptors via the involvement of hydrogen bonding and that the formed complexes were thermodynamically highly stable. Taken together, our results make 3d as a promising lead for further drugs development.

ACS Style

Ismail M.M. Othman; Mahmoud H. Mahross; Mohamed A.M. Gad-Elkareem; Mithun Rudrapal; Neelutpal Gogoi; Dipak Chetia; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations. Journal of Molecular Structure 2021, 1243, 130862 .

AMA Style

Ismail M.M. Othman, Mahmoud H. Mahross, Mohamed A.M. Gad-Elkareem, Mithun Rudrapal, Neelutpal Gogoi, Dipak Chetia, Kaïss Aouadi, Mejdi Snoussi, Adel Kadri. Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations. Journal of Molecular Structure. 2021; 1243 ():130862.

Chicago/Turabian Style

Ismail M.M. Othman; Mahmoud H. Mahross; Mohamed A.M. Gad-Elkareem; Mithun Rudrapal; Neelutpal Gogoi; Dipak Chetia; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. 2021. "Toward a treatment of antibacterial and antifungal infections: Design, synthesis and in vitro activity of novel arylhydrazothiazolylsulfonamides analogues and their insight of DFT, docking and molecular dynamic simulations." Journal of Molecular Structure 1243, no. : 130862.

Journal article
Published: 20 April 2021 in Antioxidants
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Asphodelus tenuifolius Cav. (A. tenuifolius) is a medicinal plant with a long history of traditional use to treat ailments. In this study, total phenolic and flavonoid content evaluation using LC-ESI/MS analysis and various biological activities (antioxidant, antibacterial, antifungal, antiviral and cytotoxicity) of organic extracts from the aerial parts of A. tenuifolius were analyzed. ADME tools were used to predict the potential of the identified compounds from the most potent extract as specific drugs. As shown, LC-ESI/MS results of chloroformic extract allowed the tentative identification of 12 compounds. Chloroformic extract was rich in polyphenols and flavonoids and exhibited the highest antioxidant activity given by DPPH (IC50 = 25 µg/mL) as compared to the BHT standard (11.5 µg/mL) and β-carotene bleaching assays (IC50 = 95.692 µg/mL). Antibacterial activity results showed that chloroformic extract has a highest activity against Gram-positive and -negative bacteria, especially against Salmonella Typhimurium DT104 (IZ = 19.3 mm, MIC = 18.75 mg/mL, MBC = 37.5 mg/mL). The MBC/MIC ratio was evaluated to interpret the activity that was bacteriostatic rather than bactericidal. Conversely, weaker antifungal activity was registered, and no antiviral activity was observed for all extracts against Herpes Simplex Virus type 2 and Coxsakievirus B-3 viruses. Cytotoxic activity on VERO cell line results revealed that butanol extract was not toxic, with CC50 value of 1430 µg/mL, while chloroformic extract showed moderate cytotoxicity. Additionally, in silico studies performed proved promising pharmacokinetic and drug-likeness properties of the main compounds from the chloroformic extract. Taken together, this work highlights the potent bioactivity and acceptable drug-likeness of this plant, which supports its further preclinical development.

ACS Style

Ayoub Khalfaoui; Emira Noumi; Soumia Belaabed; Kaïss Aouadi; Bouslama Lamjed; Mohd Adnan; Andrea Defant; Adel Kadri; Mejdi Snoussi; Mushtaq Khan; Ines Mancini. LC-ESI/MS-Phytochemical Profiling with Antioxidant, Antibacterial, Antifungal, Antiviral and In Silico Pharmacological Properties of Algerian Asphodelus tenuifolius (Cav.) Organic Extracts. Antioxidants 2021, 10, 628 .

AMA Style

Ayoub Khalfaoui, Emira Noumi, Soumia Belaabed, Kaïss Aouadi, Bouslama Lamjed, Mohd Adnan, Andrea Defant, Adel Kadri, Mejdi Snoussi, Mushtaq Khan, Ines Mancini. LC-ESI/MS-Phytochemical Profiling with Antioxidant, Antibacterial, Antifungal, Antiviral and In Silico Pharmacological Properties of Algerian Asphodelus tenuifolius (Cav.) Organic Extracts. Antioxidants. 2021; 10 (4):628.

Chicago/Turabian Style

Ayoub Khalfaoui; Emira Noumi; Soumia Belaabed; Kaïss Aouadi; Bouslama Lamjed; Mohd Adnan; Andrea Defant; Adel Kadri; Mejdi Snoussi; Mushtaq Khan; Ines Mancini. 2021. "LC-ESI/MS-Phytochemical Profiling with Antioxidant, Antibacterial, Antifungal, Antiviral and In Silico Pharmacological Properties of Algerian Asphodelus tenuifolius (Cav.) Organic Extracts." Antioxidants 10, no. 4: 628.

Journal article
Published: 19 March 2021 in Education Sciences
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This research study examines academic self-perceptions and course satisfaction among university students and associated factors during virtual classes. A cross-sectional online survey of (n = 328) undergraduate and postgraduate Saudi students who took virtual classes during the second semester of the academic year 2019–2020 and the first semester of the academic year 2020–2021 during the coronavirus disease 2019 (COVID-19) pandemic. The findings demonstrated students’ scores on negative academic self-perceptions (mean (M) = 9.84; standard deviation (S.D.) = 3.09) are significantly higher in comparison to positive academic self-perceptions (M = 7.71; S.D. = 2.46) and the difference was statistically significant, t(327) = 3.69, p < 0.001. The analysis demonstrated that mean differences were significant across ‘year of study’, ‘field of study’, ‘CGPA’ (cumulative grade points average), ‘employment status’, ‘on-site work’ and ‘being a parent of young child’ (p < 0.01). Correlation analysis shows a linear positive association between perceptions of workload and low technical support with negative academic self-perceptions (p < 0.001) and an inverse relationship with positive academic self-perceptions (p < 0.001). The multiple regression analysis demonstrated that the predictor variables in the model (perceptions of workload and technical support) explain 62% variance in negative academic self-perceptions and 41% variance in positive academic self-perceptions. Furthermore, the analysis demonstrated that positive academic self-perceptions bring a 32% variance in course satisfaction. These findings underscore the importance of balancing workload during online studies in higher education and provision of adequate technical support to reduce the negative academic self-perceptions which are associated with lower levels of course satisfaction. Students’ academic self-perceptions and course satisfaction during virtual studies are important factors to retain students’ motivation in learning and academic performance.

ACS Style

Sehar Hassan; Fahad Algahtani; Rafat Zrieq; Badr Aldhmadi; Amira Atta; Rawan Obeidat; Adel Kadri. Academic Self-Perception and Course Satisfaction among University Students Taking Virtual Classes during the COVID-19 Pandemic in the Kingdom of Saudi-Arabia (KSA). Education Sciences 2021, 11, 134 .

AMA Style

Sehar Hassan, Fahad Algahtani, Rafat Zrieq, Badr Aldhmadi, Amira Atta, Rawan Obeidat, Adel Kadri. Academic Self-Perception and Course Satisfaction among University Students Taking Virtual Classes during the COVID-19 Pandemic in the Kingdom of Saudi-Arabia (KSA). Education Sciences. 2021; 11 (3):134.

Chicago/Turabian Style

Sehar Hassan; Fahad Algahtani; Rafat Zrieq; Badr Aldhmadi; Amira Atta; Rawan Obeidat; Adel Kadri. 2021. "Academic Self-Perception and Course Satisfaction among University Students Taking Virtual Classes during the COVID-19 Pandemic in the Kingdom of Saudi-Arabia (KSA)." Education Sciences 11, no. 3: 134.

Journal article
Published: 10 February 2021 in Bioorganic Chemistry
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New substituted pyrazolone and dipyrazolotriazine derivatives have been synthesized, designed and well characterized as promising dual antimicrobial/antioxidant agents to overcome multidrug resistant bacteria (MDR), oxidative stress and their related diseases. Among all strains, S. aureus was found to be the most susceptible for all compounds except 10b and 12b. Out of the three investigated series, sulfonamide analogues 5a-c displayed excellent antibacterial activity with 5b (MIC = 7.61 μM) and 5a (MIC = 8.98 μM) displaying activity that exceeds the reference drug tetracycline (MIC = 11.77 μM). The same sulfonamide derivatives 5a-c demonstrates high ABTS scavenging capacity comparable to standard. Moreover, the structure-activity relationship (SAR) revealed that benzenesulfonamide is a crucial group for enhancing activity. Molecular docking studies of the potent analogues were performed by targeting the crystal structures of S. aureus tyrosyl-tRNA synthetase and human peroxiredoxin-5 enzymes and the obtained results supported well the in vitro data revealing stronger binding interactions. Pharmacokinetics prediction together with modeling outcomes suggests that our sulfonamide derivatives may serve as useful lead compounds for the treatment of infectious disease.

ACS Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis. Bioorganic Chemistry 2021, 109, 104704 .

AMA Style

Ismail M.M. Othman, Mohamed A.M. Gad-Elkareem, El Hassane Anouar, Kaïss Aouadi, Mejdi Snoussi, Adel Kadri. New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis. Bioorganic Chemistry. 2021; 109 ():104704.

Chicago/Turabian Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Kaïss Aouadi; Mejdi Snoussi; Adel Kadri. 2021. "New substituted pyrazolones and dipyrazolotriazines as promising tyrosyl-tRNA synthetase and peroxiredoxin-5 inhibitors: Design, synthesis, molecular docking and structure-activity relationship (SAR) analysis." Bioorganic Chemistry 109, no. : 104704.

Journal article
Published: 22 January 2021 in Plants
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Piper cubeba is an important plant commonly known as cubeb or Java pepper, and it is cultivated for its fruit and essential oils, largely used to treat various diseases. Up to today, there was no scientific report on wound healing activity. Thus, this study was initiated to evaluate for the first time the antimicrobial activity and wound healing potential of a new chemotype from Piper cubeba essential oil (PCEO) from fruits. Thirteen microbial strains have been selected to investigate the antimicrobial potential of PCEO. For the evaluation of the wound healing potential, sixteen rats were excised on the dorsal back and divided into four groups. The effect of PCEO on the malondialdehyde (MDA) and superoxide dismutase (SOD) activities in the healed wound area of rats and the biochemical parameters and skin histological analysis were also assessed. Results: Data showed that PCEO exhibited a powerful antimicrobial potential especially against Listeria monocytogenes and Staphylococcus aureus. In addition, the topical application of PCEO cream appears to increase the SOD level, wound healing and contraction but reduced the MDA amount suggesting an impressive and a rapid cutaneous healing power. Additionally, histopathological analysis of the granulation tissue revealed that the derma is properly restored and arranged after treatment with PCEO. The docking analysis of PCEO constituents against S. aureus tyrosyl-tRNA synthetase enzyme showed binding energies values in the range of −7.2 to −4.8 kcal/mol. In conclusion, the topic use of PCEO healing cream showed significant effect in accelerating the healing process, which may be attributed to the synergetic effect of antioxidant and antimicrobial properties of PCEO volatile constituents, making it a relevant therapeutic agent for the management of wounds and therefore confirming the popular traditional uses of this plant.

ACS Style

Fahad Alminderej; Sana Bakari; Tariq Almundarij; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein. Plants 2021, 10, 205 .

AMA Style

Fahad Alminderej, Sana Bakari, Tariq Almundarij, Mejdi Snoussi, Kaïss Aouadi, Adel Kadri. Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein. Plants. 2021; 10 (2):205.

Chicago/Turabian Style

Fahad Alminderej; Sana Bakari; Tariq Almundarij; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. 2021. "Antimicrobial and Wound Healing Potential of a New Chemotype from Piper cubeba L. Essential Oil and In Silico Study on S. aureus tyrosyl-tRNA Synthetase Protein." Plants 10, no. 2: 205.

Journal article
Published: 10 November 2020 in Plants
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Piper cubeba L. fruit is an important species used in folk medicine for different types of pains such as rheumatism, chills, flu, colds, muscular aches, and fever. This study examines the chemical constituents, antioxidant activity, and potential inhibitory effect against human peroxiredoxin 5, a key enzyme of P. cubeba essential oil from fruits. Using gas chromatography coupled with mass spectrometry (GC–MS), the principal components were methyleugenol (41.31%) and eugenol (33.95%), followed by (E)-caryophyllene (5.65%), p-cymene-8-ol (3.50%), 1,8-cineole (2.94%), and α-terpinolene (1.41%). Results showed similar scavenging activity via 2,2-diphenyl-1-picrylhydrazyl DPPH radical scavenging activity (IC50 = 110.00 ± 0.08 μg/mL), as well as very potent antioxidant activity against both ferric reducing/antioxidant power (FRAP) (106.00 ± 0.11 μg/mL) and β-carotene bleaching (IC50 = 315.00 ± 2.08 μg/mL) assays when compared to positive butylated hydroxytoluene and ascorbic acid. The molecular docking approach has also been performed to screen the antioxidant activities of the major and potent compounds against human protein target peroxiredoxin 5. Results showed good binding profiles and attributed the strongest inhibitory activity to β-caryophyllene oxide (–5.8 kcal/mol), followed respectively by isocembrol and α-selinene (–5.4 kcal/mol), and viridiflorol (–5.1 kcal/mol). Furthermore, ADME (absorption, distribution, metabolism and excretion)-related physicochemical and pharmacokinetic properties have been assessed and support our in vitro findings. This work demonstrates the powerful antioxidant potency of cubeba pepper and paves the way for the discovery and development of antioxidant agent with high potency.

ACS Style

Fahad Alminderej; Sana Bakari; Tariq I. Almundarij; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. Antioxidant Activities of a New Chemotype of Piper Cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies. Plants 2020, 9, 1534 .

AMA Style

Fahad Alminderej, Sana Bakari, Tariq I. Almundarij, Mejdi Snoussi, Kaïss Aouadi, Adel Kadri. Antioxidant Activities of a New Chemotype of Piper Cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies. Plants. 2020; 9 (11):1534.

Chicago/Turabian Style

Fahad Alminderej; Sana Bakari; Tariq I. Almundarij; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. 2020. "Antioxidant Activities of a New Chemotype of Piper Cubeba L. Fruit Essential Oil (Methyleugenol/Eugenol): In Silico Molecular Docking and ADMET Studies." Plants 9, no. 11: 1534.

Journal article
Published: 16 October 2020 in Antioxidants
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This study investigated Allium subhirsutum L. (AS) anticancer and antioxidant effects and inhibition of tumor angiogenesis in a murine model of skeletal metastases due to inoculation of Walker 256/B cells. Phytochemical composition of AS extract (ASE) was studied by High Resolution-Liquid Chromatography Mass Spectroscopy (HR-LCMS). Total phenolic and flavonoid contents (TPC and TFC) were determined. In vitro, the antioxidant properties were evaluated by reducing power and antiradical activity against DPPH. Cancer cells’ proliferation, apoptosis, metastatic development and angiogenesis were evaluated using Walker 256/B and MatLyLu cells. The p-coumaric acid was the major phenolic acid (1700 µg/g extract). ASE showed high levels of TPC and TFC and proved potent antioxidant effects. ASE inhibited Walker 256/B and MatLyLu cells’ proliferation (Half-maximal inhibitory concentration: IC50 ≃ 150 µg/mL) and induced apoptosis. In silico and in vivo assays confirmed these findings. ASE effectively acts as a chemo-preventive compound, induces apoptosis and attenuates angiogenesis and osteolytic metastases due to Walker 256/B malignant cells.

ACS Style

Riadh Badraoui; Tarek Rebai; Salem Elkahoui; Mousa Alreshidi; Vajid N. Veettil; Emira Noumi; Khaled A. Al-Motair; Kaïss Aouadi; Adel Kadri; Vincenzo De Feo; Mejdi Snoussi. Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study. Antioxidants 2020, 9, 1003 .

AMA Style

Riadh Badraoui, Tarek Rebai, Salem Elkahoui, Mousa Alreshidi, Vajid N. Veettil, Emira Noumi, Khaled A. Al-Motair, Kaïss Aouadi, Adel Kadri, Vincenzo De Feo, Mejdi Snoussi. Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study. Antioxidants. 2020; 9 (10):1003.

Chicago/Turabian Style

Riadh Badraoui; Tarek Rebai; Salem Elkahoui; Mousa Alreshidi; Vajid N. Veettil; Emira Noumi; Khaled A. Al-Motair; Kaïss Aouadi; Adel Kadri; Vincenzo De Feo; Mejdi Snoussi. 2020. "Allium subhirsutum L. as a Potential Source of Antioxidant and Anticancer Bioactive Molecules: HR-LCMS Phytochemical Profiling, In Vitro and In Vivo Pharmacological Study." Antioxidants 9, no. 10: 1003.

Journal article
Published: 17 July 2020 in Bioorganic Chemistry
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In our effort of discovering new antimicrobial agents, a novel series of imidazo[4,5-b]pyridine-5-thione scaffolds were designed and synthesized and their chemical structures were characterized by physicochemical and spectral analysis. The synthesized compounds were assessed for their in vitro antimicrobial activities against pathogenic microorganisms. Results revealed that out the tested compounds, 3 exhibited the potent inhibitory effect (MIC = 0.49 μg/mL) as compared to the positive control, chloramphenicol (0.98 μg/mL) which predicted also to have the best pharmacokinetic and druglikness properties as well as lower toxicity profiles. Preliminary structure–activity relationships (SARs) study has been also investigated. Moreover, to understand the binding patterns of the tested compounds in the Staphylococcus aureus tyrosyl-tRNA synthetase active site, molecular docking study using the most active compound 3 was carried out. The obtained results indicate that analog 3 can potentially bound to the target enzyme with the highest docking score (−9.37 kcal/mol). Overall, our results showed that antimicrobial activity as well as ADMET and toxicity predictions were in consensus with the docking results.

ACS Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Kaïss Aouadi; Adel Kadri; Mejdi Snoussi. Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors. Bioorganic Chemistry 2020, 102, 104105 .

AMA Style

Ismail M.M. Othman, Mohamed A.M. Gad-Elkareem, El Hassane Anouar, Kaïss Aouadi, Adel Kadri, Mejdi Snoussi. Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors. Bioorganic Chemistry. 2020; 102 ():104105.

Chicago/Turabian Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Kaïss Aouadi; Adel Kadri; Mejdi Snoussi. 2020. "Design, synthesis ADMET and molecular docking of new imidazo[4,5-b]pyridine-5-thione derivatives as potential tyrosyl-tRNA synthetase inhibitors." Bioorganic Chemistry 102, no. : 104105.

Journal article
Published: 12 June 2020 in Journal of Molecular Structure
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Thirteen fused pyridine derivatives have been designed, synthesized and characterized by 1H NMR, 13C NMR and IR spectral data and elemental analysis. Their in vitro antimicrobial activity was investigated against some pathogenic bacteria and fungi and the majority of them showed excellent to moderate activity, especially compounds 10 and 18 displaying the potent inhibitory effect against K. pneumoniae with MIC values of 2.44 mM and 8.10 mM, respectively. Their pharmacokinetic assessment also revealed promising druglikeness characteristics and ADME properties. The binding interactions of the most active analogues were performed through molecular docking against Staphylococcus aureus tyrosyl-tRNA synthetase. Results revealed that the enhanced activity of compound 10 can be modulated by the establishment, in 10-tyrosyltRNA synthetase complex, of hydrogen bond interactions between the lone pair of sulfur atom of the thiophen-3-amine ring and the hydrogen atom of the hydroxyl group of TYR 170 of 3.80 Å. These findings suggest that analogues 10 and 18 can be served as best candidates for designing and discovering of novel antimicrobial agents.

ACS Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies. Journal of Molecular Structure 2020, 1219, 128651 .

AMA Style

Ismail M.M. Othman, Mohamed A.M. Gad-Elkareem, El Hassane Anouar, Mejdi Snoussi, Kaïss Aouadi, Adel Kadri. Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies. Journal of Molecular Structure. 2020; 1219 ():128651.

Chicago/Turabian Style

Ismail M.M. Othman; Mohamed A.M. Gad-Elkareem; El Hassane Anouar; Mejdi Snoussi; Kaïss Aouadi; Adel Kadri. 2020. "Novel fused pyridine derivatives containing pyrimidine moiety as prospective tyrosyl-tRNA synthetase inhibitors: Design, synthesis, pharmacokinetics and molecular docking studies." Journal of Molecular Structure 1219, no. : 128651.

Journal article
Published: 01 December 2019 in Arabian Journal of Chemistry
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This study aimed to investigate and compare the total phenolic content (TPC) and total flavonoid content (TFC) and antioxidant and antibacterial activities of different extracts recovered from Date Palm Pollen collected from Tunisian cultivars of Kerkennah (DPP-K) and Tozeur (DPP-T) using various solvents, including hexane, chloroform, ethyl acetate, acetone, ethanol and water. The results revealed that DPP-T had higher TPC than DPP-K for all solvent extracts, except for hexane, with a value of 237.74±9.58mg GAE/g for the water extract. The highest level of TFC (75.10±4.37mg QE/g) was recorded in the acetone DPP-T extract, which was about twice as high as that of DPP-K. A total of eight phenolic compounds were identified and quantified in both extracts by HPLC, namely gallic acid, catechin, caffeic acid, epicatechin, vanillic acid, coumarin, quercitin and rutin. The antioxidant activities of the extracts were screened using DPPH and β-carotene bleaching assays. The results indicated that the DPP-T acetone extract showed the best DPPH scavenging activity (IC50=46.56±0.28μg/ml), with no activity being recorded for DPP-K. The DPP-T extract also showed significant effects in terms of the β-carotene test (28.12±0.04μg/ml) when compared to BHT as a reference standard. The extracts were screened for antimicrobial activity against 10 bacterial and 7 fungal strains, and the results showed that ethyl acetate DPP-K extract exhibited the strongest activity against Listeria monocytogenes and that the Staphylococcus aureus strain was most sensitive to DPP-T, with MIC and MBC values of 0.98mg/ml and 1.95mg/ml, respectively. Both DPP-T and DPP-K showed strong inhibition effects on the growth of oxysporum. Further time kill assays demonstrated the potency of DPP-K and DPP-T ethyl acetate extracts to inhibit the growth of L. monocytogenes and S. aureus, respectively. Overall, the findings suggest that DPP could be considered a promising source of new natural antioxidant and antimicrobial agents for use in various food and pharmaceutical products and formulations. This suggested that the DPP extract is a good potential inhibitor of food spoiling microbial growth and could be a highly effective therapeutic choice for human and plant infections

ACS Style

Amal Daoud; Drira Malika; Sana Bakari; Najla Hfaiedh; Kais Mnafgui; Adel Kadri; Néji Gharsallah. Assessment of polyphenol composition, antioxidant and antimicrobial properties of various extracts of Date Palm Pollen (DPP) from two Tunisian cultivars. Arabian Journal of Chemistry 2019, 12, 3075 -3086.

AMA Style

Amal Daoud, Drira Malika, Sana Bakari, Najla Hfaiedh, Kais Mnafgui, Adel Kadri, Néji Gharsallah. Assessment of polyphenol composition, antioxidant and antimicrobial properties of various extracts of Date Palm Pollen (DPP) from two Tunisian cultivars. Arabian Journal of Chemistry. 2019; 12 (8):3075-3086.

Chicago/Turabian Style

Amal Daoud; Drira Malika; Sana Bakari; Najla Hfaiedh; Kais Mnafgui; Adel Kadri; Néji Gharsallah. 2019. "Assessment of polyphenol composition, antioxidant and antimicrobial properties of various extracts of Date Palm Pollen (DPP) from two Tunisian cultivars." Arabian Journal of Chemistry 12, no. 8: 3075-3086.

Journal article
Published: 18 February 2019 in PeerJ
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Recently, herbal drugs and their bioactive compounds have gained popularity in the management of diabetes mellitus (DM), which has become an epidemic disease all over the world and is especially prevalent in the Kingdom of Saudi Arabia (KSA). This study aimed to investigate the antidiabetic effect of ethanolic and aqueous-ethanolic extracts of wildRicinus communis(R. communis) leaves in streptozotocin (STZ) induced diabetic rats. Diabetic rats were administered orally with the mentioned extracts at doses of 300 and 600 mg/kg/BW for 14 days, and the obtained results of different biochemical parameters were compared with normal control, diabetic control and standard drug glibenclamide (5 mg/kg/BW). The obtained results revealed a remarkable and significantly (P < 0.05) reverse effect of the body weight loss, observed when diabetic rats were treated with ethanol and aqueous-ethanol extracts at 300 mg/kg/BW. Administration of the ethanol extract at 600 mg/kg/BW significantly (P < 0.05) reduced the blood glucose level. A significant increase in the AST, ALT and ALP levels (P < 0.05) was observed in the diabetic control and in the experimental groups with glibenclamide which was also significantly (P < 0.05) lowered after treatment with extracts at special doses. Total proteins, albumin, total bilirubin, direct bilirubin, creatinine and urea were also investigated and compared to the corresponding controls. We showed that administration ofR. communisextract generally significantly (P < 0.05) ameliorated the biochemical parameters of diabetic rats. Also, the changes in serum electrolyte profile were assessed and the results demonstrate that administration of extracts at concentration of 600 mg/kg/BW generally inhibits the alteration maintain their levels. The obtained data imply the hypoglycemic effects of this plant, which may be used as a good alternative for managing DM and therefore validating its traditional usage in KSA.

ACS Style

Mohamed A.M. Gad-Elkareem; Elkhatim H. Abdelgadir; Ossama M. Badawy; Adel Kadri. Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats. PeerJ 2019, 7, e6441 .

AMA Style

Mohamed A.M. Gad-Elkareem, Elkhatim H. Abdelgadir, Ossama M. Badawy, Adel Kadri. Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats. PeerJ. 2019; 7 ():e6441.

Chicago/Turabian Style

Mohamed A.M. Gad-Elkareem; Elkhatim H. Abdelgadir; Ossama M. Badawy; Adel Kadri. 2019. "Potential antidiabetic effect of ethanolic and aqueous-ethanolic extracts ofRicinus communisleaves on streptozotocin-induced diabetes in rats." PeerJ 7, no. : e6441.

Journal article
Published: 07 July 2018 in International Journal of Molecular Sciences
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Endophytic fungi of healthy and brittle leaf diseased (BLD) date palm trees (Phoenix dactylifera L.) represent a promising source of bioactive compounds with biomedical, industrial, and pharmaceutical applications. The fungal endophytes Penicillium citrinum isolate TDPEF34, and Geotrichum candidum isolate TDPEF20 from healthy and BLD date palm trees, respectively, proved very effective in confrontation assays against three pathogenic bacteria, including two Gram-positive bacteria Bacillus thuringiensis (Bt) and Enterococcus faecalis (Ef), and one Gram-negative bacterium Salmonella enterica (St). They also inhibited the growth of three fungi Trichoderma sp. (Ti), Fusarium sporotrichioides (Fs), Trichoderma sp. (Ts). Additionally, their volatile organic compounds (VOCs) were shown to be in part responsible for the inhibition of Ti and Ts and could account for the full inhibition of Fs. Therefore, we have explored their potential as fungal cell factories for bioactive metabolites production. Four extracts of each endophyte were prepared using different solvent polarities, ethanol (EtOH), ethyl acetate (EtOAc), hexane (Hex), and methanol (MetOH). Both endophyte species showed varying degrees of inhibition of the bacterial and fungal pathogens according to the solvent used. These results suggest a good relationship between fungal bioactivities and their produced secondary metabolites. Targeting the discovery of potential anti-diabetic, anti-hemolysis, anti-inflammatory, anti-obesity, and cytotoxic activities, endophytic extracts showed promising results. The EtOAc extract of G. candidum displayed IC50 value comparable to the positive control diclofenac sodium in the anti-inflammatory assays. Antioxidant activity was evaluated using α,α-diphenyl-β-picrylhydrazyl (DPPH), β-carotene bleaching, reducing power (RP), and 2,2-azino-bis(3-ethylbenzothiazoline-6-sulphonique) (ABTS) radical scavenging assays. The findings revealed strong anti-oxidant power with an IC50 of 177.55 µg/mL for G. candidum EtOAc extract using DPPH assay, probably due to high polyphenol and flavonoid content in both fungal extracts. Finally, LC-HRMS (Liquid Chromatography–High Resolution Mass Spectrometry) and GC-MS (Gas Chromatography–Mass Spectrometry) analysis of G. candidum and P. citrinum extracts revealed an impressive arsenal of compounds with previously reported biological activities, partly explaining the obtained results. Finally, LC-HRMS analysis indicated the presence of new fungal metabolites that have never been reported, which represent good candidates to follow for the discovery of new bioactive molecules.

ACS Style

Fedia Ben Mefteh; Amal Daoud; Ali Chenari Bouket; Bathini Thissera; Yamina Kadri; Hafsa Cherif-Silini; Manal Eshelli; Faizah N. Alenezi; Armelle Vallat; Tomasz Oszako; Adel Kadri; José María Ros-García; Mostafa E. Rateb; Neji Gharsallah; Lassaad Belbahri. Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites. International Journal of Molecular Sciences 2018, 19, 1986 .

AMA Style

Fedia Ben Mefteh, Amal Daoud, Ali Chenari Bouket, Bathini Thissera, Yamina Kadri, Hafsa Cherif-Silini, Manal Eshelli, Faizah N. Alenezi, Armelle Vallat, Tomasz Oszako, Adel Kadri, José María Ros-García, Mostafa E. Rateb, Neji Gharsallah, Lassaad Belbahri. Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites. International Journal of Molecular Sciences. 2018; 19 (7):1986.

Chicago/Turabian Style

Fedia Ben Mefteh; Amal Daoud; Ali Chenari Bouket; Bathini Thissera; Yamina Kadri; Hafsa Cherif-Silini; Manal Eshelli; Faizah N. Alenezi; Armelle Vallat; Tomasz Oszako; Adel Kadri; José María Ros-García; Mostafa E. Rateb; Neji Gharsallah; Lassaad Belbahri. 2018. "Date Palm Trees Root-Derived Endophytes as Fungal Cell Factories for Diverse Bioactive Metabolites." International Journal of Molecular Sciences 19, no. 7: 1986.

Original article
Published: 16 April 2018 in Food Science and Technology
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Erodium glaucophyllum collected from Tunisian Sahara was never presented in the relevant literature yet. In this study, the phytochemical profiles, chemical compositions, antioxidant and antimicrobial activities, and Kill-time assay of the hydroalcoholic extract of flowers and leaves were investigated. The highest content in phenols, flavonoids and tannins was shown in flowers extract (350 ± 5 mg GAE/g, 34 ± 1 mg QE/g and 221.8 ± 0.0 mg β-carotene E/g, respectively). The carotenoids amount in leaves was about 6-fold higher than it’s in flowers. Conducted LC/MS analysis revealed the presence of 17 compounds in flowers and leaves extract with the main were quinic acid and naringin followed by rutin, hyperoside, gallic acid and Apegenin-7-o-glucoside. Flowers and leaves extracts showed a powerful antimicrobial effect against all strains and the most observed effect was shown with Gram negative bacteria. Time kill kinetics endorses the effectiveness of both extracts to possess bactericidal effect at a concentration less than 2 MIC. Results of both organs open a new promising way for the development of antioxidant and antimicrobial agents for food preservatives against food deterioration.

ACS Style

Sana Bakari; Hafedh Hajlaoui; Amal Daoud; Hedi Mighri; José Maria Ross-Garcia; Néji Gharsallah; Adel Kadri. Phytochemicals, antioxidant and antimicrobial potentials and LC-MS analysis of hydroalcoholic extracts of leaves and flowers of Erodium glaucophyllum collected from Tunisian Sahara. Food Science and Technology 2018, 38, 310 -317.

AMA Style

Sana Bakari, Hafedh Hajlaoui, Amal Daoud, Hedi Mighri, José Maria Ross-Garcia, Néji Gharsallah, Adel Kadri. Phytochemicals, antioxidant and antimicrobial potentials and LC-MS analysis of hydroalcoholic extracts of leaves and flowers of Erodium glaucophyllum collected from Tunisian Sahara. Food Science and Technology. 2018; 38 (2):310-317.

Chicago/Turabian Style

Sana Bakari; Hafedh Hajlaoui; Amal Daoud; Hedi Mighri; José Maria Ross-Garcia; Néji Gharsallah; Adel Kadri. 2018. "Phytochemicals, antioxidant and antimicrobial potentials and LC-MS analysis of hydroalcoholic extracts of leaves and flowers of Erodium glaucophyllum collected from Tunisian Sahara." Food Science and Technology 38, no. 2: 310-317.

Journal article
Published: 01 October 2017 in Experimental and Toxicologic Pathology
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The present study aimed to examine the putative preventive effect of the ethanolic extract Date Palm Pollen (DPP, Phoenix dactylifera L., family Arecaceae) on isoproterenol-induced myocardial infarction (MI) in rats. Twenty four rats were randomly divided into four groups including control. They were treated with DPP extract (400mg/kg) and clopidogrel (0.2mg/kg) for 7days followed by myocardial injury induction using subcutaneous isoproterenol (100mg/kg) with an interval of 24h for two days (6th and 7th day). Administration of isoproterenol exhibited indicative changes in the ECG pattern evidenced by significant elevation of ST-segment and cardiac injury markers viz.; troponin-T, creatine phosphokinase (CPK), alanine aminotransferase (ALT) and lactate dehydrogenase (LDH) by 315%, 71%, 64% and 170%, respectively as compared to control. Additionally, the angiotensin-converting enzyme (ACE) activity in plasma was increased by 33% associated to histological myocardial necrosis. However, pre-co-treatment with DPP extract improved the cardiac biomarkers injury, normalized cardiac function indices and prevented the ventricular remodeling process through inhibition of ACE activity by 34% and the inhibition of the generation of radical oxygen species. Extensive characterization of this DPP extract using LC-HRMS revealed numerous flavonoids and phenols compounds which could be endowed with cardiopreventive actions. Overall, these results proved that DPP extract has preventive effects on cardiac remodeling process.

ACS Style

Amal Daoud; Fedia Ben Mefteh; Kais Mnafgui; Mouna Turki; Salwa Jmal; Rawdha Ben Amar; Fatma Ayadi; Abdelfattah ElFeki; Leila Abid; Mostafa E. Rateb; Lassaad Belbahri; Adel Kadri; Neji Gharsallah. Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme. Experimental and Toxicologic Pathology 2017, 69, 656 -665.

AMA Style

Amal Daoud, Fedia Ben Mefteh, Kais Mnafgui, Mouna Turki, Salwa Jmal, Rawdha Ben Amar, Fatma Ayadi, Abdelfattah ElFeki, Leila Abid, Mostafa E. Rateb, Lassaad Belbahri, Adel Kadri, Neji Gharsallah. Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme. Experimental and Toxicologic Pathology. 2017; 69 (8):656-665.

Chicago/Turabian Style

Amal Daoud; Fedia Ben Mefteh; Kais Mnafgui; Mouna Turki; Salwa Jmal; Rawdha Ben Amar; Fatma Ayadi; Abdelfattah ElFeki; Leila Abid; Mostafa E. Rateb; Lassaad Belbahri; Adel Kadri; Neji Gharsallah. 2017. "Cardiopreventive effect of ethanolic extract of Date Palm Pollen against isoproterenol induced myocardial infarction in rats through the inhibition of the angiotensin-converting enzyme." Experimental and Toxicologic Pathology 69, no. 8: 656-665.

Research paper
Published: 02 May 2017 in Food Science and Technology
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Ecballium elaterium species are mostly used as therapeutic agents and food ingredient. The current work was designed to investigate phytochemical contents, antioxidant, antibacterial, and anti-inflammatory properties of methanol fruits extract of Ecballium elaterium. Good antioxidant activity was observed with IC50 values of 156 ± 4 and 377 ± 6 μg/mL for DPPH and ABTS, respectively, and EC50 of 126 ± 4 µg/mL for FRAP assays, which is related with their richness in total phenolic, flavonoid and condensed tannins contents. The results of antibacterial activity showed the effectiveness of methanol extract against Bacillus cereus with value of inhibition zone diameter of 15 ± 0 mm and a MIC and MBC values of 6 ± 0 and 12 ± 0 mg/mL, respectively. The in vivo anti-inflammatory effects have been also studied by carrageenan induced rat paw edema assay and the results revealed that a dose of 75 mg/kg induced a significant inhibition of 66.4% at 2 h. FT-IR spectral data justified the presence of biological functional groups such as ─OH, C─H, C─O, C─C and C=O. These results highlighted the potential using of Ecballium elaterium fruits extract as natural antimicrobial, antioxidant and anti-inflammatory agents for food applications and for the pharmaceutical industry.

ACS Style

Samir Felhi; Mongi Saoudi; Amal Daoud; Hafedh Hajlaoui; Marwa Ncir; Rim Chaabane; Abdelfattah El Feki; Néji Gharsallah; Adel Kadri. Investigation of phytochemical contents, in vitro antioxidant and antibacterial behavior and in vivo anti-inflammatory potential of Ecballium elaterium methanol fruits extract. Food Science and Technology 2017, 37, 558 -563.

AMA Style

Samir Felhi, Mongi Saoudi, Amal Daoud, Hafedh Hajlaoui, Marwa Ncir, Rim Chaabane, Abdelfattah El Feki, Néji Gharsallah, Adel Kadri. Investigation of phytochemical contents, in vitro antioxidant and antibacterial behavior and in vivo anti-inflammatory potential of Ecballium elaterium methanol fruits extract. Food Science and Technology. 2017; 37 (4):558-563.

Chicago/Turabian Style

Samir Felhi; Mongi Saoudi; Amal Daoud; Hafedh Hajlaoui; Marwa Ncir; Rim Chaabane; Abdelfattah El Feki; Néji Gharsallah; Adel Kadri. 2017. "Investigation of phytochemical contents, in vitro antioxidant and antibacterial behavior and in vivo anti-inflammatory potential of Ecballium elaterium methanol fruits extract." Food Science and Technology 37, no. 4: 558-563.

Articles
Published: 27 April 2017 in Food Science and Technology
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Ecballium elaterium is a perennial herb with multiple medicinal properties. It was widely used in folk medicine as cathartic, anti-inflammatory and analgesic agents. The present study was devoted to investigate the effect of diethyl ether, acetone, and methanol solvent on the extraction, phytochemicals profiles, antioxidant and antimicrobial activities of Ecballium elaterium seeds and peels fruits. The total phenolic, flavonoid, flavonol, condensed tannins and carotenoids contents were estimated. Maximum phenolic (107 ± 4 mg GAE/g) and flavonoid (18 ± 0 mg QE/g) contents were also found in the methanol peels fruits extract. Results showed that methanol peels fruits extract have the highest antioxidant activity with IC50 values of 1.2 ± 0.1 and 1 ± 0 mg/mL for DPPH and ABTS, respectively, and EC50 value of 1040 ± 5 mg/mL for reducing power assays. Acetone and diethyl ether peels fruits extracts showed the best antibacterial agents especially against Micrococcus luteus, however no antifungal activity was observed. Spectral data of FT-IR analysis of Ecballium elaterium seeds and peels fruits extracts revealed the presence of functional groups such as ─OH, C─H, C─O and C=O. Due to their high antioxidant and antibacterial activities, E. elaterium seeds and peels fruits extracts have promising potential as future natural antioxidant and antibacterial agents in food industry.

ACS Style

Samir Felhi; Amal Daoud; Hafedh Hajlaoui; Kais Mnafgui; Néji Gharsallah; Adel Kadri. Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits. Food Science and Technology 2017, 37, 483 -492.

AMA Style

Samir Felhi, Amal Daoud, Hafedh Hajlaoui, Kais Mnafgui, Néji Gharsallah, Adel Kadri. Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits. Food Science and Technology. 2017; 37 (3):483-492.

Chicago/Turabian Style

Samir Felhi; Amal Daoud; Hafedh Hajlaoui; Kais Mnafgui; Néji Gharsallah; Adel Kadri. 2017. "Solvent extraction effects on phytochemical constituents profiles, antioxidant and antimicrobial activities and functional group analysis of Ecballium elaterium seeds and peels fruits." Food Science and Technology 37, no. 3: 483-492.

Journal article
Published: 31 December 2016 in Food Science and Biotechnology
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The present study revealed that the nutritive value of grape seeds ( L.) was 383.55±0.13 Kcal/100 g, with magnesium as the most abundant mineral element (70.44±0.88 mg/L). The maximum phenolic (392.58±1.70mg of GAE/g), flavonoid (256.16±1.60 mg of QE/g), and tannin (30.95±0.17mg of CE/g) contents were also found in the ethanol, dichloromethane, and hexane extracts, respectively. The major phytochemical compounds in the ethyl acetate extract were identified via gas chromatography-mass spectrometry (GC-MS) analysis. The ethanol extract has the highest antioxidant activity (IC=140±1.20 μg/mL for DPPH, 145.28±0.45mg α-tocopherol/g for total antioxidant capacity, and EC=80±1.41 μg/mL for ferric-reducing power assays). For β-carotene test, the highest antioxidant activity was obtained in the hexane extract. A satisfactory antimicrobial activity was found against a panel of microorganisms with the ethyl acetate extract as the best antimicrobial agent. Additionally, it was found that the bactericidal concentration required for the grape seed extract to kill should be less than 12.50 mg/mL (minimum inhibitory concentration=4).

ACS Style

Samir Felhi; Noura Baccouch; Hichem BEN Salah; Slim Smaoui; Noureddine Allouche; Néji Gharsallah; Adel Kadri. Nutritional constituents, phytochemical profiles, in vitro antioxidant and antimicrobial properties, and gas chromatography–mass spectrometry analysis of various solvent extracts from grape seeds (Vitis vinifera L.). Food Science and Biotechnology 2016, 25, 1537 -1544.

AMA Style

Samir Felhi, Noura Baccouch, Hichem BEN Salah, Slim Smaoui, Noureddine Allouche, Néji Gharsallah, Adel Kadri. Nutritional constituents, phytochemical profiles, in vitro antioxidant and antimicrobial properties, and gas chromatography–mass spectrometry analysis of various solvent extracts from grape seeds (Vitis vinifera L.). Food Science and Biotechnology. 2016; 25 (6):1537-1544.

Chicago/Turabian Style

Samir Felhi; Noura Baccouch; Hichem BEN Salah; Slim Smaoui; Noureddine Allouche; Néji Gharsallah; Adel Kadri. 2016. "Nutritional constituents, phytochemical profiles, in vitro antioxidant and antimicrobial properties, and gas chromatography–mass spectrometry analysis of various solvent extracts from grape seeds (Vitis vinifera L.)." Food Science and Biotechnology 25, no. 6: 1537-1544.