This article provides an overview of MRI methods exploiting magnetic susceptibility properties of blood to assess cerebral oxygen metabolism, including the tissue oxygen extraction fraction (OEF) and the cerebral metabolic rate of oxygen (CMRO₂). The first section is devoted to describing blood magnetic susceptibility and its effect on the MRI signal. Blood circulating in the vasculature can have diamagnetic (oxyhemoglobin) or paramagnetic properties (deoxyhemoglobin). The overall balance between oxygenated and deoxygenated hemoglobin determines the induced magnetic field which, in turn, modulates the transverse relaxation decay of the MRI signal via additional phase accumulation. The following sections of this review then illustrate the principles underpinning susceptibility-based techniques for quantifying OEF and CMRO₂. Here, it is detailed whether these techniques provide global (OxFlow) or local (Quantitative Susceptibility Mapping - QSM, calibrated BOLD - cBOLD, quantitative BOLD - qBOLD, QSM+qBOLD) measurements of OEF or CMRO₂, and what signal components (magnitude or phase) and tissue pools they consider (intravascular or extravascular). Validations studies and potential limitations of each method are also described. The latter include (but are not limited to) challenges in the experimental setup, the accuracy of signal modeling, and assumptions on the measured signal. The last section outlines the clinical uses of these techniques in healthy aging and neurodegenerative diseases and contextualizes these reports relative to results from gold-standard PET.

Background Preclinical studies have suggested that solid-state MRI markers of cortical bone porosity, morphologic structure, mineralization, and osteoid density are useful measures of bone health. Purpose To explore whether MRI markers of cortical bone porosity, morphologic structure, mineralization, and osteoid density are affected in postmenopausal osteoporosis (OP) and to examine associations between MRI markers and bone mineral density (BMD) in postmenopausal women. Materials and Methods In this single-center study, postmenopausal women were prospectively recruited from January 2019 to October 2020 into two groups: participants with OP who had not undergone treatment, defined as having any dual-energy x-ray absorptiometry (DXA) T-score of -2.5 or less, and age-matched control participants without OP (hereafter, non-OP). Participants underwent MRI in the midtibia, along with DXA in the hip and spine, and peripheral quantitative CT in the midtibia. Specifically, MRI measures of cortical bone porosity (pore water and total water), osteoid density (bound water [BW]), morphologic structure (cortical bone thickness), and mineralization (phosphorous [P] density [³¹P] and ³¹P-to-BW concentration ratio) were quantified at 3.0 T. MRI measures were compared between OP and non-OP groups and correlations with BMD were assessed. Results Fifteen participants with OP (mean age, 63 years ± 5 [SD]) and 19 participants without OP (mean age, 65 years ± 6) were evaluated. The OP group had elevated pore water (11.6 mol/L vs 9.5 mol/L; P = .007) and total water densities (21.2 mol/L vs 19.7 mol/L; P = .03), and had lower cortical bone thickness (4.8 mm vs 5.6 mm; P < .001) and ³¹P density (6.4 mol/L vs 7.5 mol/L; P = .01) than the non-OP group, respectively, although there was no evidence of a difference in BW or ³¹P-to-BW concentration ratio. Pore and total water densities were inversely associated with DXA and peripheral quantitative CT BMD (P < .001), whereas cortical bone thickness and ³¹P density were positively associated with DXA and peripheral quantitative CT BMD (P = .01). BW, ³¹P density, and ³¹P-to-BW concentration ratio were positively associated with DXA (P < .05), but not with peripheral quantitative CT. Conclusion Solid-state MRI of cortical bone was able to help detect potential impairments in parameters reflecting porosity, morphologic structure, and mineralization in postmenopausal osteoporosis. © RSNA, 2023 Supplemental material is available for this article. See also the editorial by Bae in this issue.

Ultrashort echo time (UTE) MRI is capable of detecting signals from protons with very short T2 relaxation times, and thus has potential for skull-selective imaging as a radiation-free alternative to computed tomography. However, relatively long scan times make the technique vulnerable to artifacts from involuntary subject motion. Here, we developed a self-navigated, three-dimensional (3D) UTE pulse sequence, which builds on dual-RF, dual-echo UTE imaging, and a retrospective motion correction scheme for motion-resistant skull MRI. Full echo signals in the second readout serve as a self-navigator that yields a time-course of center of mass, allowing for adaptive determination of motion states. Furthermore, golden-means based k-space trajectory was employed to achieve a quasi-uniform distribution of sampling views on a spherical k-space surface for any subset of the entire data collected, thereby allowing reconstruction of low-resolution images pertaining to each motion state for subsequent estimation of rigid-motion parameters. Finally, the extracted trajectory of the head was used to make the whole k-space datasets motion-consistent, leading to motion-corrected, high-resolution images. Additionally, we posit that hardware-related k-space trajectory errors, if uncorrected, result in obscured bone contrast. Thus, a calibration scan was performed once to measure k-space encoding locations, subsequently used during image reconstruction of actual imaging data. In vivo studies were performed to evaluate the effectiveness of the proposed correction schemes in combination with approaches to accelerated bone-selective imaging. Results illustrating effective removal of motion artifacts and clear depiction of skull bone voxels suggest that the proposed method is robust to intermittent head motions during scanning.