Srinivasan Ramalingam

Dr. Srinivasan Ramalingam


Research Focus & Metrics

Academic Career Length

6Years (2021-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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23 April 2022 in Environmental Research
Verified
Journal Article
Closed access
DIDhatchanamoorthi Indhira
Dhatchanamoorthi Indhira
MKManikandan Krishnamoorthy
Manikandan Krishnamoorthy
FAFuad Ameen
Fuad Ameen
Sartaj Ahmad BhatSartaj Ahmad Bhat
Sartaj Ahmad Bhat
KAKathirvel Arumugam
Kathirvel Arumugam
Govindan Suresh KumarGovindan Suresh Kumar
Govindan Suresh Kumar

4 April 2023 in Processes
Verified
Journal Article
Open access
PDF file
DIDhatchanamoorthi Indhira
Dhatchanamoorthi Indhira
AAArumugam Aruna
Arumugam Aruna
KMKrishnamoorthy Manikandan
Krishnamoorthy Manikandan
MAMohammed Albeshr
Mohammed Albeshr
AAAbdulwahed Fahad Alrefaei
Abdulwahed Fahad Alrefaei
SRSrinivasan Ramalingam
Srinivasan Ramalingam
Selenium nanoparticles (Se NPs) have recently received much interest due to their low toxicity, high bioavailability, and wide applications. This study synthesized Se NPs using selenious acid as a starting material and leaf extract from Elaeagnus indica as a reducing agent. Spectroscopic and electron microscopy investigations have demonstrated the production of aggregated amorphous Se NPs with phytochemicals. Furthermore, the reduction of selenious acid into Se NPs by phytochemicals present in the leaf extract of E. indica was confirmed in a prominent band at 269 nm in the UV-visible spectrum. The biosynthesized selenium nanoparticles have a 10–15 nm particle size distribution. The agar well diffusion assay exhibited remarkable dose-dependent, wide-spectrum antimicrobial efficacy of the Se NPs against all the tested microorganisms. Moreover, the lowest minimum inhibitory concentration (10 µg/mL) was noted against Salmonella Typhimurium and Fusarium oxysporum. The prepared Se NPs degraded methylene blue dye by about 89% after 6 h of exposure to sunlight. In conclusion, the synthesis of Se NPs using E. indica leaf extract shows promise as a method for producing Se NPs with significant antimicrobial activity and potential for methylene blue photodegradation. These properties make them potentially valuable in various fields, including water treatment and biomedical applications, in the future.

11 July 2024 in Pharmaceutics
Verified
Journal Article
Open access
PDF file
Barathi SelvarajBarathi Selvaraj
Barathi Selvaraj
SRSrinivasan Ramalingam
Srinivasan Ramalingam
GKGopinath Krishnasamy
Gopinath Krishnasamy
Jintae LeeJintae Lee
Jintae Lee
As contemporary technology advances, scientists are striving to identify new approaches to managing several diseases. Compared to the more popular physiochemical synthesis, the plant-derived combination of metallic nanoparticles using plant secondary metabolites as a precursor has a number of benefits, including low expenses, low energy consumption, biocompatibility, and medicinal usefulness. This study intends to explore the impacts of using plant-derived synthetic materials including metallic nanoparticles (NPs), emphasizing the benefits of their broad use in next-generation treatments for cancer, diabetes, Alzheimer’s, and vector diseases. This comprehensive analysis investigates the potential of plant-derived remedies for diseases and looks at cutting-edge nanoformulation techniques aimed at addressing the function of the nanoparticles that accompany these organic substances. The purpose of the current review is to determine how plant extracts contribute to the synthesis of Silver nanoparticles (AgNPs), Gold nanoparticles (GtNPs), and platinum nanoparticles (PtNPs). It provides an overview of the many phytocompounds and their functions in biomedicine, including antibacterial, antioxidant, anticancer, and anti-inflammatory properties. Furthermore, this study placed a special focus on a range of applications, including drug delivery systems, diagnostics and therapy, the present benefits of nanoparticles (NPs), their biomedical uses in medical technology, and their toxicities.

12 May 2023 in International Journal of Biological Macromolecules
Verified
Journal Article
Closed access
MKMariyappan Kowsalya
Mariyappan Kowsalya
TVThangavel Velmurugan
Thangavel Velmurugan
RMR. Mythili
R. Mythili
WKWoong Kim
Woong Kim
KSKattakgounder Govindaraj Sudha
Kattakgounder Govindaraj Sudha
MRMohan Prasanna Rajeshkumar
Mohan Prasanna Rajeshkumar

27 January 2022 in Foods
Verified
Journal Article
Open access
PDF file
SRSrinivasan Ramalingam
Srinivasan Ramalingam
DBDr. Ashutosh Bahuguna
Dr. Ashutosh Bahuguna
SLSeMi Lim
SeMi Lim
AJAh-Ryeong Joe
Ah-Ryeong Joe
JLJong-Suk Lee
Jong-Suk Lee
Myunghee KimMyunghee Kim
Myunghee Kim
Gochujang, fermented red pepper paste, is a grain-based Korean traditional food. The quality of gochujang produced by cottage industries is not well-documented. Thus, the present study aimed to analyze the quality of gochujang from 35 traditional cottage industries for physicochemical and microbial characteristics, along with volatile compound contents. In addition to microbial characteristics, salinity, pH, free amino nitrogen, and alcohol content were evaluated. Ethanol was detected as the predominant alcohol and 57% of tested gochujang products harbored >1% of total alcohol content, which was above the recommended level for halal products. Gochujang products contained hexadecanoic and linoleic acids predominantly and several volatile compounds belonging to the classes of alcohols, aldehydes, alkanes, nitrogen-containing compounds, and terpenes. A wide range of aerobic mesophilic bacteria (2.79–8.73 log CFU/g) and yeast counts (1.56–7.15 log CFU/g) was observed. Five distinct yeast species were identified, including Zygosaccharomyces rouxii. Eight gochujang products were found to be contaminated with Bacillus cereus (>4 log CFU/g). This study suggests that there is a need to limit B. cereus contamination in cottage industry products and reduce alcohol content to comply with halal food guidelines.

7 January 2025 in Nanomaterials
Verified
Journal Article
Open access
PDF file
AKA. Kathirvel
A. Kathirvel
SRSrinivasan Ramalingam
Srinivasan Ramalingam
SHSathasivam Harini
Sathasivam Harini
NRNatarajan Ranjith
Natarajan Ranjith
Govindan Suresh KumarGovindan Suresh Kumar
Govindan Suresh Kumar
HYHae Keun Yun
Hae Keun Yun
Zirconium dioxide nanoparticles (ZrO2 NPs) have gained significant attention due to their excellent bioavailability, low toxicity, and diverse applications in the medical and industrial fields. In this study, ZrO2 NPs were synthesized using zirconyl oxychloride and the aqueous leaf extract of Toddalia asiatica as a stabilizing agent. Analytical techniques, including various spectroscopy methods and electron microscopy, confirmed the formation of aggregated spherical ZrO2 NPs, ranging from 15 to 30 nm in size, with mixed-phase structure composed of tetragonal and monoclinic structures. UV–visible spectroscopy showed a characteristic band at 281 nm with a bandgap energy of 3.7 eV, indicating effective stabilization by the phytochemicals in T. asiatica. EDX analysis revealed that the NPs contained 37.18 mol.% zirconium (Zr) and 62.82 mol.% oxygen. The ZrO2 NPs demonstrated remarkable photocatalytic activity, degrading over 95% of methylene blue dye after 3 h of sunlight exposure. Additionally, the ZrO2 NPs exhibited strong antibacterial effects, particularly against Gram-negative bacteria such as E. coli, and significant antioxidant activity, with low IC50 values for hydroxyl radical scavenging. In conclusion, the green synthesis of ZrO2 NPs using T. asiatica leaf extract is an effective, eco-friendly method that produces nanoparticles with remarkable antioxidant, antimicrobial, and photocatalytic properties, highlighting their potential for applications in water treatment, environmental remediation, and biomedicine.