Alan Sinclair

Prof. Alan Sinclair


Research Focus & Metrics

Academic Career Length

17Years (2010-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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1 July 2012 in Journal of the American Medical Directors Association
Verified
Journal Article
Open access
ASAlan Sinclair
Alan Sinclair
JMJohn E. Morley
John E. Morley
LMLeocadio Rodríguez Mañas
Leocadio Rodríguez Mañas
Giuseppe PaolissoGiuseppe Paolisso
Giuseppe Paolisso
TBTony Bayer
Tony Bayer
KLKate Lorig
Kate Lorig
Diabetes mellitus is a highly prevalent metabolic condition in ageing societies associated with high levels of morbidity, multiple therapies, and functional deterioration that challenges even the best of health care systems to deliver high-quality, individualized care. Most international clinical guidelines have ignored the often-unique issues of frailty, functional limitation, changes in mental health, and increasing dependency that characterize many aged patients with diabetes. A collaborative Expert Group of the IAGG and EDWPOP and an International Task Force have explored the key issues that affect diabetes in older people using a robust method comprising a Delphi process and an evidence-based review of the literature. Eight domains of interest were initially agreed and discussed: hypoglycemia, therapy, care home diabetes, influence of comorbidities, glucose targets, family/carer perspectives, diabetes education, and patient safety. A set of "consensus" statements was produced in each domain of interest. These form a foundation for future policy development in this area and should influence the clinical behavior and approach of all health professionals engaged in delivering diabetes care to older people.

1 April 2015 in The Lancet Diabetes & Endocrinology
Verified
Journal Article
Closed access
ASAlan Sinclair
Alan Sinclair
TDTrisha Dunning
Trisha Dunning
LMLeocadio Rodríguez Mañas
Leocadio Rodríguez Mañas

1 January 2015 in Aging and disease
Verified
Journal Article
Open access
PDF file
AAAhmed H Abdelhafiz
Ahmed H Abdelhafiz
LMLeocadio Rodríguez Mañas
Leocadio Rodríguez Mañas
JMJohn E. Morley
John E. Morley
ASAlan Sinclair
Alan Sinclair
Recurrent hypoglycemia is common in older people with diabetes and is likely to be less recognized and under reported by patients and health care professionals. Hypoglycemia in this age group is associated with significant morbidities leading to both physical and cognitive dysfunction. Repeated hospital admissions due to frequent hypoglycemia are also associated with further deterioration in patients' general health. This negative impact of hypoglycemia is likely to eventually lead to frailty, disability and poor outcomes. It appears that the relationship between hypoglycemia and frailty is bidirectional and mediated through a series of influences including under nutrition. Therefore, attention should be paid to the management of under nutrition in the general elderly population by improving energy intake and maintaining muscle mass. Increasing physical activity and having a more conservative approach to glycemic targets in frail older people with diabetes may be worthwhile.

1 November 2011 in Diabetes & Metabolism
Verified
Journal Article
Closed access
ASAlan Sinclair
Alan Sinclair
Giuseppe PaolissoGiuseppe Paolisso
Giuseppe Paolisso
MCMarta Castro
Marta Castro
IBIsabelle Bourdel-Marchasson
Isabelle Bourdel-Marchasson
RGRoger Gadsby
Roger Gadsby
LMLeocadio Rodríguez Mañas
Leocadio Rodríguez Mañas

1 September 2017 in Journal of Diabetes and its Complications
Verified
Journal Article
Closed access
ASAlan Sinclair
Alan Sinclair
AAAhmed H. Abdelhafiz
Ahmed H. Abdelhafiz
LMLeocadio Rodríguez Mañas
Leocadio Rodríguez Mañas

1 January 2018 in The Journal of Frailty & Aging
Verified
Journal Article
Open access
PDF file
ASAlan Sinclair
Alan Sinclair
AAA. Abdelhafiz
A. Abdelhafiz
TDT. Dunning
T. Dunning
Mikel IzquierdoMikel Izquierdo
Mikel Izquierdo
LML. Rodriguez Manas
L. Rodriguez Manas
BVB. Vellas
B. Vellas
The the International Position Statement provides the opportunity to summarise all existing clinical trial and best practice evidence for older people with