The COVID-19 pandemic forced a quick change of the teaching styles to online lessons; specifically, experimental classes had to be redesigned to achieve the best possible academic performance within the imposed limitations. This work describes three different approaches: adaptation of a laboratory chemistry course to an online mode, learning proficiency, and students’ perception. First, a compilation of experiments that cover topics from general chemistry at an undergraduate level was included, with activities that can be conducted employing daily-use materials and substances. Next, the learning achieved was estimated, and the grades were related to a domain level of competency acquisition. The results indicated that at least 68% accomplished the highest level. Finally, the perception of the participants about the activities was inquired. The statistical analysis showed a generalized positive attitude towards the mode proposed, an appreciation of having earned meaningful knowledge, and most of the students stated they would recommend the course.