Being the main pillar in the context of Industry 4.0, the Internet of Things (IoT) leads evolution towards a smarter and safer planet. Being human-centered, rather than machine-centered, as was the case of wireless sensor networks used in the industry for decades, the IoT may enhance human intelligence with situational awareness, early warning, and decision support tools. Focusing on air cargo transportation, the “INTELLICONT” project presented a novel solution capable of improving critical air cargo challenges such as the reduction of total aircraft weight, detection and suppression of smoke and/or fire in a container, elimination of permanent moving and locking hardware, loading and unloading logistics enhancement and maintenance. In the present work, the IoT-based monitoring and control system for intelligent aircraft cargo containers is presented from a hardware perspective. The system is based on low-cost, low-energy sensors that are integrated into the container, can track its status, and detect critical events, such as fire/smoke, impact, and accidental misuse. The focus has been given to the design and development of a system capable of providing better and safer control of the aircraft cargo during the loading/unloading operations and the flight. It is shown that the system could provide a breakthrough in the state of the art of current cargo container technology and aircraft cargo operations.