Prof. Anna Aiello
University Federico II of Naples
+2
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Academic Career Length
24Years (2003-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
Marialuisa Menna
Concetta ImperatoreFDFilomena D'Aniello
Filomena D'AnielloAnna AielloMeroterpenes are widely distributed among marine organisms; they are particularly abundant within brown algae, but other important sources include microorganisms and invertebrates. In the present review the structures and bioactivities of meroterpenes from marine invertebrates, mainly sponges and tunicates, are summarized. More than 300 molecules, often complex and with unique skeletons originating from intra- and inter-molecular cyclizations, and/or rearrangements, are illustrated. The reported syntheses are mentioned. The issue of a potential microbial link to their biosynthesis is also shortly outlined.
Journal Article
Concetta ImperatoreAnna AielloFDFilomena D'Aniello
Filomena D'AnielloMSMaria Senese
Maria SeneseMarialuisa MennaThe present review describes research on novel natural antitumor alkaloids isolated from marine invertebrates. The structure, origin, and confirmed cytotoxic activity of more than 130 novel alkaloids belonging to several structural families (indoles, pyrroles, pyrazines, quinolines, and pyridoacridines), together with some of their synthetic analogs, are illustrated. Recent discoveries concerning the current state of the potential and/or development of some of them as new drugs, as well as the current knowledge regarding their modes of action, are also summarized. A special emphasis is given to the role of marine invertebrate alkaloids as an important source of leads for anticancer drug discovery.
Journal Article
Marcello CasertanoConcetta ImperatorePLPaolo Luciano
Paolo LucianoAnna Aiello
Masteria Yunovilsa PutraMarialuisa Menna +2
A deep study of the metabolic content of the tunicate Polycarpa aurata, collected from Indonesian coast, afforded the isolation of two novel alkaloids, polyaurines A (1) and B (2), along with two new p-substituted benzoyl derivatives (3 and 4) and four known compounds (5–8). The structural elucidation of the new secondary metabolites was assigned by 1D, 2D NMR, and HRESIMS techniques. Computational studies resulted a useful tool to unambiguously determine in polyaurine B the presence of rarely found 1,2,4-thiadiazole ring. The effects of polyaurines A and B on mammalian cells growth and on the viability of different blood-dwelling Schistosoma mansoni (phylum: Platyhelminthes) stages, as well as egg production, were evaluated. Both compounds resulted not cytotoxic; interestingly some of the eggs produced by polyaurine A-treated adult pairs in vitro are smaller, deformed, and/or fragmented; therefore, polyaurine A could represent an interesting bioactive natural molecule to be further investigated.
Journal Article
Concetta ImperatoreRGRoberto Gimmelli
Roberto GimmelliMPMarco Persico
Marco PersicoMarcello CasertanoAGAlessandra Guidi
Alessandra GuidiMarialuisa Menna +8
The chemical analysis of the sponge Dysidea avara afforded the known sesquiterpene quinone avarone, along with its reduced form avarol. To further explore the role of the thiazinoquinone scaffold as an antiplasmodial, antileishmanial and antischistosomal agent, we converted the quinone avarone into the thiazinoquinone derivative thiazoavarone. The semisynthetic compound, as well as the natural metabolites avarone and avarol, were pharmacologically investigated in order to assess their antiparasitic properties against sexual and asexual stages of Plasmodium falciparum, larval and adult developmental stages of Schistosoma mansoni (eggs included), and also against promastigotes and amastigotes of Leishmania infantum and Leishmania tropica. Furthermore, in depth computational studies including density functional theory (DFT) calculations were performed. A toxic semiquinone radical species which can be produced starting both from quinone- and hydroquinone-based compounds could mediate the anti-parasitic effects of the tested compounds.
Journal Article
Anna AielloEFErnesto Fattorusso
Ernesto FattorussoConcetta ImperatoreMarialuisa Menna
Werner E.G. MüllerChemical investigation of the Mediterranean ascidian Ciona edwardsii has been performed, leading to the isolation of two halogenated compounds: a new tyrosine-iodinated derivative iodocionin (1) and the relevant brominated analogue (2), previously isolated from a Caribbean sponge. The structure of the new compound 1 has been assigned on the basis of spectroscopic analysis.Both compounds were tested for cytotoxicity in vitro against two different cancer cell lines, L5178Y (mouse lymphoma) and PC-12 (rat pheochromocytoma). Iodocionin was shown to possess significant and selective activity against lymphoma cells with an IC50 of 7.75 μg/mL.
Journal Article
MGMassimo Genovese
Massimo GenoveseConcetta ImperatoreMarcello CasertanoAnna Aiello
Francesco Balestri
Paolo Paoli +3
An in-depth study on the inhibitory mechanism on protein tyrosine phosphatase 1B (PTP1B) and aldose reductase (AR) enzymes, including analysis of the insulin signalling pathway, of phosphoeleganin, a marine-derived phosphorylated polyketide, was achieved. Phosphoeleganin was demonstrated to inhibit both enzymes, acting respectively as a pure non-competitive inhibitor of PTP1B and a mixed-type inhibitor of AR. In addition, in silico docking analyses to evaluate the interaction mode of phosphoeleganin with both enzymes were performed. Interestingly, this study showed that phosphoeleganin is the first example of a dual inhibitor polyketide extracted from a marine invertebrate, and it could be used as a versatile scaffold structure for the synthesis of new designed multiple ligands.
About Me
Anna Aiello was born in Sorrento (Italy) and on 1984 was graduated in Chemistry at the University of Naples Federico II ;in 1990 she obtained the title of PhD Pharmaceutical Science. In 2002 she was called by the Faculty of Pharmacy of the University of Naples to fill the role of Associate Professor in the Organic Chemistry group. From 1998 to 2022 she was in charge of numerous courses relating to the subject area CHIM06. She was elected Coordinator of the Degree in Pharmacy for the period 2014-20. She is a member of the Organizing Committee of the Postgraduate School of Chemical Risk Assessment and Management, and of the Board of the School of Medicine and Surgeryan. She was appointed by the Rector of University of Naples Delegate for Teaching for the three-year period 2021-2023. The research activity is documented by the ownership of two international patents, several publications in international journals with referees, and reviews. She has participated in numerous national and international conferences. The research activity carried out is part of the field of investigation of the chemistry of natural organic substances focuses on the chemical and pharmacological characterization of metabolites isolated from marine invertebrates with structural peculiarities and interesting pharmacological activities (histamine antagonist, neuroprotective, antitumor, antimalarial). Since 1996, he has undertaken a systematic study of the tunicates present in the Mediterranean area.