In order to make full use of underground space resources and reasonably determine the development function and scale, it is important to evaluate the suitability evaluation of urban underground space (UUS). The development and utilization of underground space is affected by many factors, such as topography, geomorphology, geotechnical characteristics, hydrogeology and so on. Taking the starting area of Changjiang New Town in Wuhan as a case study, this paper introduces the rough set theory and conditional entropy and establishes a suitability evaluation model of UUS. Rough set theory is used to construct a decision information table, preprocess sample data and classify the knowledge base, while conditional entropy is employed to calculate the attributes’ own and relative importance. Then, the fuzzy comprehensive evaluation method, the most unfavorable grade discrimination method and the exclusive method are used to evaluate the model, and the partition map of regional underground space development suitability is obtained. In this method, any prior knowledge and additional information will not be needed except the sample data, and the obtained weights are more objective and reasonable. The results show that the overall suitability of underground space development and utilization in the starting area of Wuhan Changjiang New Town is good.