Depression is a multifactorial psychiatric condition with complex pathophysiology, increasingly linked to neuroinflammatory processes. The present review explores the role of neuroinflammation in depression, focusing on glial cell activation, cytokine signaling, blood–brain barrier dysfunction, and disruptions in neurotransmitter systems. The article highlights how inflammatory mediators influence brain regions implicated in mood regulation, such as the hippocampus, amygdala, and prefrontal cortex. The review further discusses the involvement of the hypothalamic–pituitary–adrenal (HPA) axis, oxidative stress, and the kynurenine pathway, providing mechanistic insights into how chronic inflammation may underlie emotional and cognitive symptoms of depression. The bidirectional relationship between inflammation and depressive symptoms is emphasized, along with the role of peripheral immune responses and systemic stress. By integrating molecular, cellular, and neuroendocrine perspectives, this review supports the growing field of immunopsychiatry and lays the foundation for novel diagnostic biomarkers and anti-inflammatory treatment approaches in depression. Further research in this field holds promise for developing more effective and personalized interventions for individuals suffering from depression.

Adolescence represents a critical developmental stage where diet, gut microorganisms, and mental health are strongly interconnected. The current literature evidences the bidirectional role between dietary habits and psychological well-being, which is mediated by the gut–brain axis. The purpose of this review is to highlight the importance of dietary habits in adolescence period and the impact of different food choices on microbiota and secondary on mental health. Gut microbiota plays a vital role in the synthesis of neurotransmitters such as serotonin, dopamine, noradrenaline, and metabolites like short-chain fatty acids (SCFAs). The disruption in the composition of microbiota is called dysbiosis, which has been associated with a systemic inflammation state and chronic stress. They contribute to the onset of psychiatric disorders including MDD, anxiety, ADHD, and autism. Diets with a high quantity of sugar and low fiber contribute to alteration of microbiota and poor mental health. Additionally, early-life stress, antibiotic usage, and chronic inflammation may alter bacterial communities, with long-term implications for adolescents mental health. Dietary interventions, including the intake of prebiotics, probiotics, SCFAs, and micronutrients could restore microbial balance and improve psychiatric symptoms. This literature review highlights the critical role of diet and gut microbiota for adolescent mental health and emphasizes the need for integrative strategies to promote psychological resilience through microbiome regulation.

Fixed orthodontic therapies include several procedures that can affect the enamel surface. The aim of this study was to assess the action of composite resin on the surface of the tooth through variation of enamel changes after debonding metal and ceramic brackets, by means of scanning electron microscopy. An in vitro study was conducted on 48 human premolar specimens, which were extracted within a period of two months for orthodontic purposes. On half of them, metal brackets were bonded, and on the other half, ceramic brackets (Al₂O₃) were bonded, using light cure adhesive paste and a two-step, etch-and-bonding technique. The brackets were debonded after 24 h using a straight debonding plier. The adhesive remnant index (ARI) was determined by visual observation of the specimen. Post-debonding scans were aligned with the baseline, and the surfaces’ changes were quantified. A quantitative analysis was made on the debonded brackets to determine the presence or absence of enamel on the base pad. Evaluation of pre-bonded and post-clean-up enamel surface revealed no crack and increased roughness in both ceramic and metal brackets, which was higher for the ceramic ones. The enameled band (perikymata), artificial caries, or the superficial fissures revealed in the pretreatment stage were replaced with the loss of the prismatic structure and the presence of remnant adhesive. No enamel substance was found on the base pad. The ARI_tooth was higher for metallic brackets than for ceramic ones. Metallic brackets and ceramic brackets have undergone mechanical changes by showing fractures in their structure. According to our present investigation, we can conclude that the adhesive composite resin is safe for use on both metal and ceramic brackets in orthodontic treatments, with no iatrogenic enamel damages.

Cobalt-chromium (Co-Cr) alloys are widely utilized in dentistry. The salivary pH is a significant factor, which affects the characteristics and the behavior of dental alloys through corrosion. This study aimed to evaluate the corrosion behavior in artificial saliva with different pH values (3, 5.7, and 7.6) of two commercial Co-Cr dental alloys manufactured by casting and by milling. Corrosion resistance was determined by the polarization resistance technique, and the tests were carried out at 37 ± 1 °C, in Carter Brugirard artificial saliva. After the electrochemical parameters, it can be stated that the cast Co-Cr alloy has the lowest corrosion current density, the highest polarization resistance, and the lowest speed of corrosion in artificial saliva with pH = 7.6. In the case of milled Co-Cr alloy, the same behavior was observed, but in artificial saliva with pH = 5.7, it recorded the most electropositive values of open circuit potential and corrosion potential. Although both cast and milled Co-Cr alloys presented a poorer corrosion resistance in artificial saliva with a more acidic pH value, the milled Co-Cr alloy had better corrosion behavior, making this alloy a better option for the prosthetic treatment of patients suffering from GERD.

Friction is an intensely studied feature in orthodontics, as the sliding mechanics approach remains one of the most utilized techniques in current practice, and the question of whether self-ligating brackets produce less friction than conventional brackets still stands. The objective of this study was to compare a self-ligating system with different closing mechanisms and a conventional system with different ligating mechanisms regarding their frictional properties. Laboratory measurements were performed using an advanced materials testing machine generating tensile strength and load at maximum Load values, which were statistically analyzed and compared. These two parameters have been associated with the frictional resistance generated at the archwire–bracket slot interface. Statistically significant results were obtained when comparing the active self-ligating brackets with the passive self-ligating (tensile strength mean 1.953, SD 0.4231; load at maximum moad mean 6.000, SD 1.3000) and conventional brackets (tensile strength mean 1.953, SD 0.4231; load at maximum load mean 6.000, SD 1.3000), as well as when comparing the passive self-ligating brackets with the conventional brackets (tensile strength mean 1.708, SD 0.8628; load at maximum load mean 5.254, SD 2.645). The active self-ligating brackets tended to produce more friction when compared to the passive self-ligating brackets but were similar to conventional brackets with stainless steel ligatures.

Digital impression devices are used alternatively to conventional impression techniques and materials. The aim of this study was to evaluate the precision of extraoral digitalization of three types of photosensitive resin polymers used for 3D printing with the aid of a digital extraoral optical scanner. The alignment of the scans was performed by a standard best-fit alignment. Trueness and precision were used to evaluate the models. The trueness was evaluated by using bias as a measure and the standard deviation was used to evaluate the precision. After assessing the normality of the distributions, an independent Kruskal–Wallis test was used to compare the trueness and precision across the material groups. The Mann–Whitney test was used as a post-hoc test for significant differences. The result of the analysis showed significant differences (U = 66, z = −2.337, p = 0.019) in trueness of mesiodistal distances. Upon visual inspection of the models, defects were noticed on two out of nine of the models printed with a photosensitive polymer. The defects were presented as cavities caused by air bubbles and were also reflected in the scans. Mean precision did not vary too much between these three photosensitive polymer resins, therefore, the selection of 3D printing materials should be based on the trueness and the required precision of the clinical purpose of the model.