This page has only limited features, please log in for full access.

Unclaimed
Pierre P. D. Kondiah
Wits Advanced Drug Delivery Platform Research Unit, Department of Pharmacy and Pharmacology, School of Therapeutic Sciences, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown, Johannesburg 2193, South Africa

Honors and Awards

The user has no records in this section


Career Timeline

The user has no records in this section.


Short Biography

The user biography is not available.
Following
Followers
Co Authors
The list of users this user is following is empty.
Following: 0 users

Feed

Review
Published: 22 July 2021 in Polymers
Reads 0
Downloads 0

In many clinical applications, the transdermal route is used as an alternative approach to avoid the significant limitations associated with oral drug delivery. There is a long history for drug delivery through the skin utilizing transdermal microneedle arrays. Microneedles are reported to be versatile and very efficient devices. This technique has spurred both industrial and scientific curiosity, due to its outstanding characteristics such as painless penetration, affordability, excellent medicinal efficiency, and relative protection. Microneedles possess outstanding properties for diverse biomedical uses such as the delivery of very large substances with ionic and hydrophilic physicochemical properties. Importantly, microneedles are applicable in numerous biomedical fields such as therapy, diagnosis, and vaccine administration. Microneedles are emerging tools that have shown profound potential for biomedical applications. Transdermal microneedle technologies are likely to become a preferred route of therapeutic substances administration in the future since they are effective, painless, and affordable. In this review, we summarize recent advances in microneedles for therapeutic applications. We explore their constituent materials and fabrication methods that improve the delivery of critical therapeutic substances through the skin. We further discuss the practicality of advanced microneedles used as drug delivery tools.

ACS Style

Sipho Mdanda; Philemon Ubanako; Pierre Kondiah; Pradeep Kumar; Yahya Choonara. Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies. Polymers 2021, 13, 2405 .

AMA Style

Sipho Mdanda, Philemon Ubanako, Pierre Kondiah, Pradeep Kumar, Yahya Choonara. Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies. Polymers. 2021; 13 (15):2405.

Chicago/Turabian Style

Sipho Mdanda; Philemon Ubanako; Pierre Kondiah; Pradeep Kumar; Yahya Choonara. 2021. "Recent Advances in Microneedle Platforms for Transdermal Drug Delivery Technologies." Polymers 13, no. 15: 2405.

Review
Published: 29 April 2021 in Polymers
Reads 0
Downloads 0

Nanotechnology has aided in the advancement of drug delivery for the treatment of several neurological disorders including depression. Depression is a relatively common mental disorder which is characterized by a severe imbalance of neurotransmitters. Several current therapeutic regimens against depression display drawbacks which include low bioavailability, delayed therapeutic outcome, undesirable side effects and drug toxicity due to high doses. The blood–brain barrier limits the entry of the drugs into the brain matrix, resulting in low bioavailability and tissue damage due to drug accumulation. Due to their size and physico-chemical properties, nanotechnological drug delivery systems present a promising strategy to enhance the delivery of nanomedicines into the brain matrix, thereby improving bioavailability and limiting toxicity. Furthermore, ligand-complexed nanocarriers can improve drug specificity and antidepressant efficacy and reduce drug toxicity. Biopolymers and nanocarriers can also be employed to enhance controlled drug release and reduce the hepatic first-pass effect, hence reducing the dosing frequency. This manuscript reviews recent advances in different biopolymers, such as polysaccharides and other nanocarriers, for targeted antidepressant drug delivery to the brain. It probes nano-based strategies that can be employed to enhance the therapeutic efficacy of antidepressants through the oral, intranasal, and parenteral routes of administration.

ACS Style

Fadzai Mutingwende; Pierre Kondiah; Philemon Ubanako; Thashree Marimuthu; Yahya Choonara. Advances in Nano-Enabled Platforms for the Treatment of Depression. Polymers 2021, 13, 1431 .

AMA Style

Fadzai Mutingwende, Pierre Kondiah, Philemon Ubanako, Thashree Marimuthu, Yahya Choonara. Advances in Nano-Enabled Platforms for the Treatment of Depression. Polymers. 2021; 13 (9):1431.

Chicago/Turabian Style

Fadzai Mutingwende; Pierre Kondiah; Philemon Ubanako; Thashree Marimuthu; Yahya Choonara. 2021. "Advances in Nano-Enabled Platforms for the Treatment of Depression." Polymers 13, no. 9: 1431.

Review
Published: 26 April 2021 in Molecules
Reads 0
Downloads 0

Tissue engineering is known to encompass multiple aspects of science, medicine and engineering. The development of systems which are able to promote the growth of new cells and tissue components are vital in the treatment of severe tissue injury and damage. This can be done through a variety of different biofabrication strategies including the use of hydrogels, 3D bioprinted scaffolds and nanotechnology. The incorporation of stem cells into these systems and the advantage of this is also discussed. Biopolymers, those which have a natural original, have been particularly advantageous in tissue engineering systems as they are often found within the extracellular matrix of the human body. The utilization of biopolymers has become increasing popular as they are biocompatible, biodegradable and do not illicit an immune response when placed into the body. Tissue engineering systems for use with the eye are also discussed. This is of particular interest as the eye is known as an immune privileged site resulting in an extremely limited ability for natural cell regeneration.

ACS Style

Courtney Lynch; Pierre Kondiah; Yahya Choonara. Advanced Strategies for Tissue Engineering in Regenerative Medicine: A Biofabrication and Biopolymer Perspective. Molecules 2021, 26, 2518 .

AMA Style

Courtney Lynch, Pierre Kondiah, Yahya Choonara. Advanced Strategies for Tissue Engineering in Regenerative Medicine: A Biofabrication and Biopolymer Perspective. Molecules. 2021; 26 (9):2518.

Chicago/Turabian Style

Courtney Lynch; Pierre Kondiah; Yahya Choonara. 2021. "Advanced Strategies for Tissue Engineering in Regenerative Medicine: A Biofabrication and Biopolymer Perspective." Molecules 26, no. 9: 2518.

Review
Published: 19 April 2021 in Expert Opinion on Therapeutic Patents
Reads 0
Downloads 0

: Among all the anti-schistosomal drug, praziquantel has been the most widely used. However, some major challenges have been faced using the drug in the treatment of schistosome infections. : Several approaches used in the synthesis of praziquantel aimed at reducing the time and cost of production, the toxicity and experimental harsh conditions are discussed. Also, patented methods involved in the pharmaceutical reformulation of praziquantel in the treatment of diverse endoparasitic infestation are reported. Additionally, future perspectives in terms of nanomedicine approach in the formulation of praziquantel are highlighted. : Lipid-based nanosystems (LBNSs) formulations can be used to overcome the shortcomings associated with the used of praziquantel in the schistosomiasis treatment due to their amphiphatic nature. This could be a promising vehicle for the delivery of praziquantel, which could in turn improve the bioavailability, as well as reduce the frequent dose of the drug and improve patient compliance. This may sustain release of the drug and improve the rapid conversion of the drug into inactive metabolite due to rapid metabolism. Additionally, LBNSs approach could increase and improve the lipophilicity of the drug, which could make it easier to interact with the hydrophobic cores of the worm tegument.

ACS Style

Tayo A. Adekiya; Pradeep Kumar; Pierre P.D. Kondiah; Viness Pillay; Yahya E. Choonara. Synthesis and therapeutic delivery approaches for praziquantel: a patent review (2010-present). Expert Opinion on Therapeutic Patents 2021, 1 -15.

AMA Style

Tayo A. Adekiya, Pradeep Kumar, Pierre P.D. Kondiah, Viness Pillay, Yahya E. Choonara. Synthesis and therapeutic delivery approaches for praziquantel: a patent review (2010-present). Expert Opinion on Therapeutic Patents. 2021; ():1-15.

Chicago/Turabian Style

Tayo A. Adekiya; Pradeep Kumar; Pierre P.D. Kondiah; Viness Pillay; Yahya E. Choonara. 2021. "Synthesis and therapeutic delivery approaches for praziquantel: a patent review (2010-present)." Expert Opinion on Therapeutic Patents , no. : 1-15.

Journal article
Published: 21 August 2020 in Polymers
Reads 0
Downloads 0

Poor circulation stability and inadequate cell membrane penetration are significant impediments in the implementation of nanocarriers as delivery systems for therapeutic agents with low bioavailability. This research discusses the fabrication of a biocompatible poly(lactide-co-glycolide) (PLGA) based nanocarrier with cationic and hydrophilic surface properties provided by natural polymer chitosan and coating polymer polyethylene glycol (PEG) for the entrapment of the hydrophobic drug disulfiram. The traditional emulsification solvent evaporation method was compared to a microfluidics-based method of fabrication, with the optimisation of the parameters for each method, and the PEGylation densities on the experimental nanoparticle formulations were varied. The size and surface properties of the intermediates and products were characterised and compared by dynamic light scattering, scanning electron microscopy and X-ray diffraction, while the thermal properties were investigated using thermogravimetric analysis and differential scanning calorimetry. Results showed optimal particle properties with an intermediate PEG density and a positive surface charge for greater biocompatibility, with nanoparticle surface characteristics shielding physical interaction of the entrapped drug with the exterior. The formulations prepared using the microfluidic method displayed superior surface charge, entrapment and drug release properties. The final system shows potential as a component of a biocompatible nanocarrier for poorly soluble drugs.

ACS Style

Divesha Essa; Yahya E. Choonara; Pierre P. D. Kondiah; Viness Pillay. Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques. Polymers 2020, 12, 1882 .

AMA Style

Divesha Essa, Yahya E. Choonara, Pierre P. D. Kondiah, Viness Pillay. Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques. Polymers. 2020; 12 (9):1882.

Chicago/Turabian Style

Divesha Essa; Yahya E. Choonara; Pierre P. D. Kondiah; Viness Pillay. 2020. "Comparative Nanofabrication of PLGA-Chitosan-PEG Systems Employing Microfluidics and Emulsification Solvent Evaporation Techniques." Polymers 12, no. 9: 1882.

Review
Published: 16 July 2020 in Applied Sciences
Reads 0
Downloads 0

The burgeoning field of nanotechnology aims to create and deploy nanoscale structures, devices, and systems with novel, size-dependent properties and functions. The nanotechnology revolution has sparked radically new technologies and strategies across all scientific disciplines, with nanotechnology now applied to virtually every area of research and development in the US and globally. NanoFlorida was founded to create a forum for scientific exchange, promote networking among nanoscientists, encourage collaborative research efforts across institutions, forge strong industry-academia partnerships in nanoscience, and showcase the contributions of students and trainees in nanotechnology fields. The 2019 NanoFlorida International Conference expanded this vision to emphasize national and international participation, with a focus on advances made in translating nanotechnology. This review highlights notable research in the areas of engineering especially in optics, photonics and plasmonics and electronics; biomedical devices, nano-biotechnology, nanotherapeutics including both experimental nanotherapies and nanovaccines; nano-diagnostics and -theranostics; nano-enabled drug discovery platforms; tissue engineering, bioprinting, and environmental nanotechnology, as well as challenges and directions for future research.

ACS Style

Shyam S. Mohapatra; Robert D. Frisina; Subhra Mohapatra; Kevin B. Sneed; Eleni Markoutsa; Tao Wang; Rinku Dutta; Ratka Damnjanovic; Manh-Huong Phan; Daniel J. Denmark; Manas R. Biswal; Andrew R. McGill; Ryan Green; Mark Howell; Payal Ghosh; Alejandro Gonzalez; Nadia Tasnim Ahmed; Brittney Borresen; Mitchell Farmer; Melissa Gaeta; Krishna Sharma; Christen Bouchard; Danielle Gamboni; Jamie Martin; Bianca Tolve; Mandip Singh; Jack W. Judy; Chenzhong Li; Swadeshmukul Santra; Sylvia Daunert; Elnaz Zeynaloo; Ryan M. Gelfand; Steven Lenhert; Eric S. McLamore; Dong Xiang; Victoria Morgan; Lisa E. Friedersdorf; Ratnesh Lal; Thomas J. Webster; David P. Hoogerheide; Thanh Duc Nguyen; Martin J. D'souza; Mustafa Çulha; Pierre P. D. Kondiah; Donald K. Martin. Advances in Translational Nanotechnology: Challenges and Opportunities. Applied Sciences 2020, 10, 4881 .

AMA Style

Shyam S. Mohapatra, Robert D. Frisina, Subhra Mohapatra, Kevin B. Sneed, Eleni Markoutsa, Tao Wang, Rinku Dutta, Ratka Damnjanovic, Manh-Huong Phan, Daniel J. Denmark, Manas R. Biswal, Andrew R. McGill, Ryan Green, Mark Howell, Payal Ghosh, Alejandro Gonzalez, Nadia Tasnim Ahmed, Brittney Borresen, Mitchell Farmer, Melissa Gaeta, Krishna Sharma, Christen Bouchard, Danielle Gamboni, Jamie Martin, Bianca Tolve, Mandip Singh, Jack W. Judy, Chenzhong Li, Swadeshmukul Santra, Sylvia Daunert, Elnaz Zeynaloo, Ryan M. Gelfand, Steven Lenhert, Eric S. McLamore, Dong Xiang, Victoria Morgan, Lisa E. Friedersdorf, Ratnesh Lal, Thomas J. Webster, David P. Hoogerheide, Thanh Duc Nguyen, Martin J. D'souza, Mustafa Çulha, Pierre P. D. Kondiah, Donald K. Martin. Advances in Translational Nanotechnology: Challenges and Opportunities. Applied Sciences. 2020; 10 (14):4881.

Chicago/Turabian Style

Shyam S. Mohapatra; Robert D. Frisina; Subhra Mohapatra; Kevin B. Sneed; Eleni Markoutsa; Tao Wang; Rinku Dutta; Ratka Damnjanovic; Manh-Huong Phan; Daniel J. Denmark; Manas R. Biswal; Andrew R. McGill; Ryan Green; Mark Howell; Payal Ghosh; Alejandro Gonzalez; Nadia Tasnim Ahmed; Brittney Borresen; Mitchell Farmer; Melissa Gaeta; Krishna Sharma; Christen Bouchard; Danielle Gamboni; Jamie Martin; Bianca Tolve; Mandip Singh; Jack W. Judy; Chenzhong Li; Swadeshmukul Santra; Sylvia Daunert; Elnaz Zeynaloo; Ryan M. Gelfand; Steven Lenhert; Eric S. McLamore; Dong Xiang; Victoria Morgan; Lisa E. Friedersdorf; Ratnesh Lal; Thomas J. Webster; David P. Hoogerheide; Thanh Duc Nguyen; Martin J. D'souza; Mustafa Çulha; Pierre P. D. Kondiah; Donald K. Martin. 2020. "Advances in Translational Nanotechnology: Challenges and Opportunities." Applied Sciences 10, no. 14: 4881.

Journal article
Published: 17 June 2020 in Current Pharmaceutical Design
Reads 0
Downloads 0

Carbon nanodots are zero-dimensional spherical allotropes of carbon and are less than 10nm in size (ranging from 2-8nm). Based on their biocompatibility, remarkable water solubility, eco- friendliness, conductivity, desirable optical properties and low toxicity, carbon dots have revolutionized the biomedical field. In addition, they have intrinsic photo-luminesce to facilitate bio-imaging, bio-sensing and theranostics. Carbon dots are also ideal for targeted drug delivery. Through functionalization of their surfaces for attachment of receptor-specific ligands, they ultimately result in improved drug efficacy and a decrease in side-effects. This feature may be ideal for effective chemo-, gene- and antibiotic-therapy. Carbon dots also comply with green chemistry principles with regard to their safe, rapid and eco-friendly synthesis. Carbon dots thus, have significantly enhanced drug delivery and exhibit much promise for future biomedical applications. The purpose of this review is to elucidate the various applications of carbon dots in biomedical fields. In doing so, this review highlights the synthesis, surface functionalization and applicability of biodegradable polymers for the synthesis of carbon dots. It further highlights a myriad of biodegradable, biocompatible and cost-effective polymers that can be utilized for the fabrication of carbon dots. The limitations of these polymers are illustrated as well. Additionally, this review discusses the application of carbon dots in theranostics, chemo-sensing and targeted drug delivery systems. This review also serves to discuss the various properties of carbon dots which allow chemotherapy and gene therapy to be safer and more target-specific, resulting in the reduction of side effects experienced by patients and also the overall increase in patient compliance and quality of life.

ACS Style

Eemaan N. Cohen; Pierre P.D. Kondiah; Yahya E. Choonara; Lisa C. Du Toit; Viness Pillay. Carbon Dots as Nanotherapeutics for Biomedical Application. Current Pharmaceutical Design 2020, 26, 2207 -2221.

AMA Style

Eemaan N. Cohen, Pierre P.D. Kondiah, Yahya E. Choonara, Lisa C. Du Toit, Viness Pillay. Carbon Dots as Nanotherapeutics for Biomedical Application. Current Pharmaceutical Design. 2020; 26 (19):2207-2221.

Chicago/Turabian Style

Eemaan N. Cohen; Pierre P.D. Kondiah; Yahya E. Choonara; Lisa C. Du Toit; Viness Pillay. 2020. "Carbon Dots as Nanotherapeutics for Biomedical Application." Current Pharmaceutical Design 26, no. 19: 2207-2221.

Review
Published: 24 February 2020 in Cancers
Reads 0
Downloads 0

Routes of drug administration and their corresponding physiochemical characteristics play major roles in drug therapeutic efficiency and biological effects. Each route of delivery has favourable aspects and limitations. The oral route of delivery is the most convenient, widely accepted and safe route. However, the oral route of chemotherapeutics to date have displayed high gastric degradation, low aqueous solubility, poor formulation stability and minimum intestinal absorption. Thus, mainstream anti-cancer drugs in current formulations are not suitable as oral chemotherapeutic formulations. The use of biopolymers such as chitosan, gelatin, hyaluronic acid and polyglutamic acid, for the synthesis of oral delivery platforms, have potential to help overcome problems associated with oral delivery of chemotherapeutics. Biopolymers have favourable stimuli-responsive properties, and thus can be used to improve oral bioavailability of anti-cancer drugs. These biopolymeric formulations can protect gastric-sensitive drugs from pH degradation, target specific binding sites for targeted absorption and consequently control drug release. In this review, the use of various biopolymers as oral drug delivery systems for chemotherapeutics will be discussed.

ACS Style

Vanessa T. Chivere; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment. Cancers 2020, 12, 522 .

AMA Style

Vanessa T. Chivere, Pierre P. D. Kondiah, Yahya E. Choonara, Viness Pillay. Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment. Cancers. 2020; 12 (2):522.

Chicago/Turabian Style

Vanessa T. Chivere; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. 2020. "Nanotechnology-Based Biopolymeric Oral Delivery Platforms for Advanced Cancer Treatment." Cancers 12, no. 2: 522.

Journal article
Published: 17 February 2020 in Pharmaceutics
Reads 0
Downloads 0

A 3D bioprinted pseudo-bone drug delivery scaffold was fabricated to display matrix strength, matrix resilience, as well as porous morphology of healthy human bone. Computer-aided design (CAD) software was employed for developing the 3D bioprinted scaffold. Further optimization of the scaffold was undertaken using MATLAB® software and artificial neural networks (ANN). Polymers employed for formulating the 3D scaffold comprised of polypropylene fumarate (PPF), free radical polymerized polyethylene glycol- polycaprolactone (PEG-PCL-PEG), and pluronic (PF127). Simvastatin was incorporated into the 3D bioprinted scaffolds to further promote bone healing and repair properties. The 3D bioprinted scaffold was characterized for its chemical, morphological, mechanical, and in vitro release kinetics for evaluation of its behavior for application as an implantable scaffold at the site of bone fracture. The ANN-optimized 3D bioprinted scaffold displayed significant properties as a controlled release platform, demonstrating drug release over 20 days. The 3D bioprinted scaffold further displayed formation as a pseudo-bone matrix, using a human clavicle bone model, induced with a butterfly fracture. The strength of the pseudo-bone matrix, evaluated for its matrix hardness (MH) and matrix resilience (MR), was evaluated to be as strong as original bone, having a 99% MH and 98% MR property, to healthy human clavicle bones.

ACS Style

Pariksha Jolene Kondiah; Pierre P. D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Viness Pillay. A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering. Pharmaceutics 2020, 12, 166 .

AMA Style

Pariksha Jolene Kondiah, Pierre P. D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, Viness Pillay. A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering. Pharmaceutics. 2020; 12 (2):166.

Chicago/Turabian Style

Pariksha Jolene Kondiah; Pierre P. D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Viness Pillay. 2020. "A 3D Bioprinted Pseudo-Bone Drug Delivery Scaffold for Bone Tissue Engineering." Pharmaceutics 12, no. 2: 166.

Review
Published: 29 January 2020 in Nanomaterials
Reads 0
Downloads 0

Cerium oxide nanoparticles have been used in a number of non-medical products over the years. The therapeutic application of these nanoparticles has mainly been due to their oxidative stress ameliorating abilities. Their enzyme-mimetic catalytic ability to change between the Ce3+ and Ce4+ species makes them ideal for a role as free-radical scavengers for systemic diseases as well as neurodegenerative diseases. In this review, we look at various methods of synthesis (including the use of stabilizing/capping agents and precursors), and how the synthesis method affects the physicochemical properties, their behavior in biological environments, their catalytic abilities as well as their reported toxicity.

ACS Style

Mpumelelo Nyoka; Yahya E. Choonara; Pradeep Kumar; Pierre P. D. Kondiah; Viness Pillay. Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications. Nanomaterials 2020, 10, 242 .

AMA Style

Mpumelelo Nyoka, Yahya E. Choonara, Pradeep Kumar, Pierre P. D. Kondiah, Viness Pillay. Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications. Nanomaterials. 2020; 10 (2):242.

Chicago/Turabian Style

Mpumelelo Nyoka; Yahya E. Choonara; Pradeep Kumar; Pierre P. D. Kondiah; Viness Pillay. 2020. "Synthesis of Cerium Oxide Nanoparticles Using Various Methods: Implications for Biomedical Applications." Nanomaterials 10, no. 2: 242.

Review
Published: 15 January 2020 in Cancers
Reads 0
Downloads 0

Despite advances achieved in medicine, chemotherapeutics still has detrimental side effects with ovarian cancer (OC), accounting for numerous deaths among females. The provision of safe, early detection and active treatment of OC remains a challenge, in spite of improvements in new antineoplastic discovery. Nanosystems have shown remarkable progress with impact in diagnosis and chemotherapy of various cancers, due to their ideal size; improved drug encapsulation within its interior core; potential to minimize drug degradation; improve in vivo drug release kinetics; and prolong blood circulation times. However, nanodrug delivery systems have few limitations regarding its accuracy of tumour targeting and the ability to provide sustained drug release. Hence, a cogent and strategic approach has focused on nanosystem functionalization with antibody-based ligands to selectively enhance cellular uptake of antineoplastics. Antibody functionalized nanosystems are (advanced) synthetic candidates, with a broad range of efficiency in specific tumour targeting, whilst leaving normal cells unaffected. This article comprehensively reviews the present status of nanosystems, with particular emphasis on nanomicelles for molecular diagnosis and treatment of OC. In addition, biomarkers of nanosystems provide important prospects as chemotherapeutic strategies to upsurge the survival rate of patients with OC.

ACS Style

Jonathan M. Pantshwa; Pierre P. D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Viness Pillay. Nanodrug Delivery Systems for the Treatment of Ovarian Cancer. Cancers 2020, 12, 213 .

AMA Style

Jonathan M. Pantshwa, Pierre P. D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, Viness Pillay. Nanodrug Delivery Systems for the Treatment of Ovarian Cancer. Cancers. 2020; 12 (1):213.

Chicago/Turabian Style

Jonathan M. Pantshwa; Pierre P. D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Viness Pillay. 2020. "Nanodrug Delivery Systems for the Treatment of Ovarian Cancer." Cancers 12, no. 1: 213.

Review
Published: 06 January 2020 in Molecules
Reads 0
Downloads 0

Chitosan can form interpolymer complexes (IPCs) with anionic polymers to form biomedical platforms (BMPs) for wound dressing/healing applications. This has resulted in its application in various BMPs such as gauze, nano/microparticles, hydrogels, scaffolds, and films. Notably, wound healing has been highlighted as a noteworthy application due to the remarkable physical, chemical, and mechanical properties enabled though the interaction of these polyelectrolytes. The interaction of chitosan and anionic polymers can improve the properties and performance of BMPs. To this end, the approaches employed in fabricating wound dressings was evaluated for their effect on the property–performance factors contributing to BMP suitability in wound dressing. The use of chitosan in wound dressing applications has had much attention due to its compatible biological properties. Recent advancement includes the control of the degree of crosslinking and incorporation of bioactives in an attempt to enhance the physicochemical and physicomechanical properties of wound dressing BMPs. A critical issue with polyelectrolyte-based BMPs is that their effective translation to wound dressing platforms has yet to be realised due to the unmet challenges faced when mimicking the complex and dynamic wound environment. Novel BMPs stemming from the IPCs of chitosan are discussed in this review to offer new insight into the tailoring of physical, chemical, and mechanical properties via fabrication approaches to develop effective wound dressing candidates. These BMPs may pave the way to new therapeutic developments for improved patient outcomes.

ACS Style

Hillary Mndlovu; Lisa C. du Toit; Pradeep Kumar; Yahya E. Choonara; Thashree Marimuthu; Pierre P. D. Kondiah; Viness Pillay. Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings. Molecules 2020, 25, 222 .

AMA Style

Hillary Mndlovu, Lisa C. du Toit, Pradeep Kumar, Yahya E. Choonara, Thashree Marimuthu, Pierre P. D. Kondiah, Viness Pillay. Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings. Molecules. 2020; 25 (1):222.

Chicago/Turabian Style

Hillary Mndlovu; Lisa C. du Toit; Pradeep Kumar; Yahya E. Choonara; Thashree Marimuthu; Pierre P. D. Kondiah; Viness Pillay. 2020. "Bioplatform Fabrication Approaches Affecting Chitosan-Based Interpolymer Complex Properties and Performance as Wound Dressings." Molecules 25, no. 1: 222.

Review article
Published: 20 December 2019 in Pharmaceutical Development and Technology
Reads 0
Downloads 0

Mortality rate of patients infected with HIV-1 has been significantly reduced by using HAART. However, the virus to date has not been eradicated. Transmission of HIV-1 infection through sexual intercourse remains an ongoing challenge, with increased risk of infection occurring in women. Interestingly, ARV drugs can be chemically linked with lipids to produce lipid–drug conjugates (LDCs). This alters pharmacokinetic properties of ARV drugs and thereby resulting in improved effectiveness. Although LDCs can be administered without a delivery carrier, they are usually incorporated into suitable delivery systems such as lipid nanoparticles, polymeric nanoparticles, micelles, liposomes, emulsions, and carbon nanotubes. Given that LDCs have the potential to improve oral bioavailability, lipophilicity, toxicity, and drug targeting, it is of our great interest to review strategies of lipid–drug conjugation together with their delivery systems for enhanced antiretroviral efficacy.

ACS Style

Funanani Takalani; Pradeep Kumar; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. Lipid–drug conjugates and associated carrier strategies for enhanced antiretroviral drug delivery. Pharmaceutical Development and Technology 2019, 25, 267 -280.

AMA Style

Funanani Takalani, Pradeep Kumar, Pierre P. D. Kondiah, Yahya E. Choonara, Viness Pillay. Lipid–drug conjugates and associated carrier strategies for enhanced antiretroviral drug delivery. Pharmaceutical Development and Technology. 2019; 25 (3):267-280.

Chicago/Turabian Style

Funanani Takalani; Pradeep Kumar; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. 2019. "Lipid–drug conjugates and associated carrier strategies for enhanced antiretroviral drug delivery." Pharmaceutical Development and Technology 25, no. 3: 267-280.

Review
Published: 06 December 2019 in Cancers
Reads 0
Downloads 0

Traditional cancer therapeutics are limited by factors such as multi-drug resistance and a plethora of adverse effect. These limitations need to be overcome for the progression of cancer treatment. In order to overcome these limitations, multifunctional nanosystems have recently been introduced into the market. The employment of multifunctional nanosystems provide for the enhancement of treatment efficacy and therapeutic effect as well as a decrease in drug toxicity. However, in addition to these effects, magnetic nanowires bring specific advantages over traditional nanoparticles in multifunctional systems in terms of the formulation and application into a therapeutic system. The most significant of which is its larger surface area, larger net magnetic moment compared to nanoparticles, and interaction under a magnetic field. This results in magnetic nanowires producing a greater drug delivery and therapeutic platform with specific regard to magnetic drug targeting, magnetic hyperthermia, and magnetic actuation. This, in turn, increases the potential of magnetic nanowires for decreasing adverse effects and improving patient therapeutic outcomes. This review focuses on the design, fabrication, and future potential of multifunctional magnetic nanowire systems with the emphasis on improving patient chemotherapeutic outcomes.

ACS Style

Abu Bakr A. Nana; Thashree Marimuthu; Pierre P. D. Kondiah; Yahya E. Choonara; Lisa C. Du Toit; Viness Pillay. Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics. Cancers 2019, 11, 1956 .

AMA Style

Abu Bakr A. Nana, Thashree Marimuthu, Pierre P. D. Kondiah, Yahya E. Choonara, Lisa C. Du Toit, Viness Pillay. Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics. Cancers. 2019; 11 (12):1956.

Chicago/Turabian Style

Abu Bakr A. Nana; Thashree Marimuthu; Pierre P. D. Kondiah; Yahya E. Choonara; Lisa C. Du Toit; Viness Pillay. 2019. "Multifunctional Magnetic Nanowires: Design, Fabrication, and Future Prospects as Cancer Therapeutics." Cancers 11, no. 12: 1956.

Review
Published: 07 October 2019 in Cells
Reads 0
Downloads 0

Understanding cell–nanoparticle interactions is critical to developing effective nanosized drug delivery systems. Nanoparticles have already advanced the treatment of several challenging conditions including cancer and human immunodeficiency virus (HIV), yet still hold the potential to improve drug delivery to elusive target sites. Even though most nanoparticles will encounter blood at a certain stage of their transport through the body, the interactions between nanoparticles and blood cells is still poorly understood and the importance of evaluating nanoparticle hemocompatibility is vastly understated. In contrast to most review articles that look at the interference of nanoparticles with the intricate coagulation cascade, this review will explore nanoparticle hemocompatibility from a cellular angle. The most important functions of the three cellular components of blood, namely erythrocytes, platelets and leukocytes, in hemostasis are highlighted. The potential deleterious effects that nanoparticles can have on these cells are discussed and insight is provided into some of the complex mechanisms involved in nanoparticle–blood cell interactions. Throughout the review, emphasis is placed on the importance of undertaking thorough, all-inclusive hemocompatibility studies on newly engineered nanoparticles to facilitate their translation into clinical application.

ACS Style

Kara M. De La Harpe; Pierre P.D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Lisa C. Du Toit; Viness Pillay. The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis. Cells 2019, 8, 1209 .

AMA Style

Kara M. De La Harpe, Pierre P.D. Kondiah, Yahya E. Choonara, Thashree Marimuthu, Lisa C. Du Toit, Viness Pillay. The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis. Cells. 2019; 8 (10):1209.

Chicago/Turabian Style

Kara M. De La Harpe; Pierre P.D. Kondiah; Yahya E. Choonara; Thashree Marimuthu; Lisa C. Du Toit; Viness Pillay. 2019. "The Hemocompatibility of Nanoparticles: A Review of Cell–Nanoparticle Interactions and Hemostasis." Cells 8, no. 10: 1209.

Review
Published: 22 August 2019 in Polymers
Reads 0
Downloads 0

Diabetes mellitus (DM) is a chronic metabolic illness estimated to have affected 451 million individuals to date, with this number expected to significantly rise in the coming years. There are two main classes of this disease, namely type 1 diabetes (T1D) and type 2 diabetes (T2D). Insulin therapy is pivotal in the management of diabetes, with diabetic individuals taking multiple daily insulin injections. However, the mode of administration has numerous drawbacks, resulting in poor patient compliance. In order to optimize insulin therapy, novel drug delivery systems (DDSes) have been suggested, and alternative routes of administration have been investigated. A novel aspect in the field of drug delivery was brought about by the coalescence of polymeric science and nanotechnology. In addition to polymeric nanoparticles (PNPs), insulin DDSes can incorporate the use of nanoplatforms/carriers. A combination of these systems can bring about novel formulations and lead to significant improvements in the drug delivery system (DDS) with regard to therapeutic efficacy, bioavailability, increased half-life, improved transport through physical and chemical barriers, and controlled drug delivery. This review will discuss how recent developments in polymer chemistry and nanotechnology have been employed in a multitude of platforms as well as in administration routes for the safe and efficient delivery of insulin for the treatment of DM.

ACS Style

Shazia Mansoor; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. Polymer-Based Nanoparticle Strategies for Insulin Delivery. Polymers 2019, 11, 1380 .

AMA Style

Shazia Mansoor, Pierre P. D. Kondiah, Yahya E. Choonara, Viness Pillay. Polymer-Based Nanoparticle Strategies for Insulin Delivery. Polymers. 2019; 11 (9):1380.

Chicago/Turabian Style

Shazia Mansoor; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. 2019. "Polymer-Based Nanoparticle Strategies for Insulin Delivery." Polymers 11, no. 9: 1380.

Review
Published: 20 August 2019 in Polymers
Reads 0
Downloads 0

The effective delivery of drugs to the eye remains a challenge. The eye has a myriad of defense systems and physiological barriers that leaves ocular drug delivery systems with low bioavailability profiles. This is mainly due to poor permeability through the epithelia and rapid clearance from the eye following administration. However, recent advances in both polymeric drug delivery and biomedical nanotechnology have allowed for improvements to be made in the treatment of ocular conditions. The employment of biodegradable polymers in ocular formulations has led to improved retention time, greater bioavailability and controlled release through mucoadhesion to the epithelia in the eye, amongst other beneficial properties. Nanotechnology has been largely investigated for uses in the medical field, ranging from diagnosis of disease to treatment. The nanoscale of these developing drug delivery systems has helped to improve the penetration of drugs through the various ocular barriers, thus improving bioavailability. This review will highlight the physiological barriers encountered in the eye, current conventional treatment methods as well as how polymeric drug delivery and nanotechnology can be employed to optimize drug penetration to both the anterior and posterior segment of the eye.

ACS Style

Courtney Lynch; Pierre P. D. Kondiah; Yahya E. Choonara; Lisa du Toit; Naseer Ally; Viness Pillay. Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery. Polymers 2019, 11, 1371 .

AMA Style

Courtney Lynch, Pierre P. D. Kondiah, Yahya E. Choonara, Lisa du Toit, Naseer Ally, Viness Pillay. Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery. Polymers. 2019; 11 (8):1371.

Chicago/Turabian Style

Courtney Lynch; Pierre P. D. Kondiah; Yahya E. Choonara; Lisa du Toit; Naseer Ally; Viness Pillay. 2019. "Advances in Biodegradable Nano-Sized Polymer-Based Ocular Drug Delivery." Polymers 11, no. 8: 1371.

Review
Published: 22 February 2019 in Pharmaceutics
Reads 0
Downloads 0

Transdermal drug delivery systems (TDDS) show clear advantages over conventional routes of drug administration. Nonetheless, there are limitations to current TDDS which warrant further research to improve current TDD platforms. Spurred by the synthesis of novel biodegradable ionic liquids (ILs) and favorable cytotoxicity studies, ILs were shown to be a possible solution to overcome these challenges. Their favorable application in overcoming challenges ranging from synthesis, manufacture, and even therapeutic benefits were documented. In this review, said ILs are highlighted and their role in TDDS is reviewed in terms of (a) ILs as permeation enhancers (single agents or combined), (b) ILs in drug modification, and (c) ILs as active pharmaceutical ingredients. Furthermore, future combination of ILs with other chemical permeation enhancers (CPEs) is proposed and discussed.

ACS Style

Zainul Sidat; Thashree Marimuthu; Pradeep Kumar; Lisa C. du Toit; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery. Pharmaceutics 2019, 11, 96 .

AMA Style

Zainul Sidat, Thashree Marimuthu, Pradeep Kumar, Lisa C. du Toit, Pierre P. D. Kondiah, Yahya E. Choonara, Viness Pillay. Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery. Pharmaceutics. 2019; 11 (2):96.

Chicago/Turabian Style

Zainul Sidat; Thashree Marimuthu; Pradeep Kumar; Lisa C. du Toit; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. 2019. "Ionic Liquids as Potential and Synergistic Permeation Enhancers for Transdermal Drug Delivery." Pharmaceutics 11, no. 2: 96.

Journal article
Published: 10 June 2018 in Molecules
Reads 0
Downloads 0

The complete synthesis, optimization, purification, functionalization and evaluation of vertically aligned multiwalled carbon nanotubes (VA-MWCNTs) was reported for potential application in dexamethasone delivery to the ischemic brain tissue. The conditions for high yield were optimized and carbon nanotubes functionalized and PEGylated prior to dexamethasone loading. Morphological changes were confirmed by SEM and TEM. Addition of functional groups to MWCNTs was demonstrated by FTIR. Thermal stability reduced following MWCNTs functionalization as demonstrated in TGA. The presence of carbon at 2θ of 25° and iron at 2θ of 45° in MWCNTs was illustrated by XRD. Polydispersive index and zeta potential were found to be 0.261 and −15.0 mV, respectively. Dexamethasone release increased by 55%, 65% and 95% in pH of 7.4, 6.5 and 5.5 respectively as evaluated by UV-VIS. The functionalized VA-MWCNTs were demonstrated to be less toxic in PC-12 cells in the concentration range from 20 to 20,000 µg/mL. These findings have demonstrated the potential of VA-MWCNTs in the enhancement of fast and prolonged release of dexamethasone which could lead to the effective treatment of ischemic stroke. More work is under way for targeting ischemic sites using atrial natriuretic peptide antibody in stroke rats.

ACS Style

Patrick P. Komane; Pradeep Kumar; Thashree Marimuthu; Lisa C. du Toit; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention. Molecules 2018, 23, 1406 .

AMA Style

Patrick P. Komane, Pradeep Kumar, Thashree Marimuthu, Lisa C. du Toit, Pierre P. D. Kondiah, Yahya E. Choonara, Viness Pillay. Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention. Molecules. 2018; 23 (6):1406.

Chicago/Turabian Style

Patrick P. Komane; Pradeep Kumar; Thashree Marimuthu; Lisa C. du Toit; Pierre P. D. Kondiah; Yahya E. Choonara; Viness Pillay. 2018. "Dexamethasone-Loaded, PEGylated, Vertically Aligned, Multiwalled Carbon Nanotubes for Potential Ischemic Stroke Intervention." Molecules 23, no. 6: 1406.

Journal article
Published: 22 April 2018 in Materials Science and Engineering: C
Reads 0
Downloads 0

A series of three dual-responsive ‘thermosonic’ (thermo- and ultrasound-responsive) injectable organogels (TIOs) based on crosslinked N-(isopropyl acrylamide) (NIPAM) bearing biocompatible polymeric constituents were investigated for strong gelation in response to tumour temperature, and sol-like fluid gel formation upon the application of an ultrasonic stimulus. A time-efficient free radical polymerisation reaction of ˂15 min resulted in TIO formation. Moreover, the formulation of the TIOs integrated green chemistry principles to ensure enhanced biocompatibility. Fourier Transform Infrared (FTIR) spectral analysis revealed the presence of new molecular vibrations at 847 and 771 cm−1 (CH deformation), which were indicative of the functionalisation of the NIPAM backbone with hydrophobic and ultrasound-responsive aromatic moieties. Thermo- and ultrasound-response analysis and rheological analysis demonstrated that the TIOs displayed a temperature-induced transition to a strong highly-structured gel, and an ultrasound-triggered increase in gel flowability dependant on the composition of the formulation. Cell proliferation studies were undertaken for the TIOs, which verified that the designed TIOs were all non-cytotoxic and promoted cell proliferation over 1, 3, and 5 day intervals. The rational design and formulation of a biocompatible injectable in-situ depot drug delivery system for ultimate application in tumour targeting was successfully achieved and warrant further investigation.

ACS Style

A. Zardad; M. Mabrouk; Thashree Marimuthu; Lisa du Toit; Pradeep Kumar; Y.E. Choonara; Pierre Kondiah; R.V. Badhe; Dharmesh Chejara; V. Pillay. Synthesis and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting. Materials Science and Engineering: C 2018, 90, 148 -158.

AMA Style

A. Zardad, M. Mabrouk, Thashree Marimuthu, Lisa du Toit, Pradeep Kumar, Y.E. Choonara, Pierre Kondiah, R.V. Badhe, Dharmesh Chejara, V. Pillay. Synthesis and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting. Materials Science and Engineering: C. 2018; 90 ():148-158.

Chicago/Turabian Style

A. Zardad; M. Mabrouk; Thashree Marimuthu; Lisa du Toit; Pradeep Kumar; Y.E. Choonara; Pierre Kondiah; R.V. Badhe; Dharmesh Chejara; V. Pillay. 2018. "Synthesis and biocompatibility of dual-responsive thermosonic injectable organogels based on crosslinked N-(isopropyl acrylamide) for tumour microenvironment targeting." Materials Science and Engineering: C 90, no. : 148-158.