In order to effectively suppress the negative effects of salt ions contained in saline soils on agricultural soil quality and crop growth, this study took advantage of the water-saving properties and better soil improvement properties of poly-γ-glutamic acid (γ-PGA). By carrying out various experiments, the following relationships have been found. (1) The lab experiment studies the effect of the γ-PGA application on the infiltration of sandy loam soil. The application rates of γ-PGA are 0%, 0.1%, 0.2%, and 0.3%, respectively. (2) HYDRUS-1D is used to simulate water infiltration of sandy loam soil under multiple factors (bulk density, γ-PGA application rate, and the application depth of γ-PGA). (3) The effect of γ-PGA on soil solute (Cl⁻) transport is also explored in this paper. The results show that bulk density and the application depth of γ-PGA (p < 0.01) have higher effects on cumulative infiltration than the application amount of γ-PGA (p < 0.05). A lower γ-PGA application rate will increase the proportion of unavailable soil water by 3%. The established empirical models have good results. Furthermore, when the γ-PGA application rate is 0.3% (0.02-cm² min⁻¹), the Cl⁻ hydrodynamic dispersion coefficient is the highest. The study recommends applying the γ-PGA at 1.4 g cm⁻³, 5–20 cm, and 0.2%. The results of this study are conducive to an in-depth understanding of the physicochemical properties of poly-γ-glutamic acid, improving the utilization rate of salinized land, achieving agricultural water and fertilizer conservation and yield enhancement, and guaranteeing sustainable land use and sustainable development of agroecological environment.