High forming force is often needed when high-strength and low-plasticity materials are processed by fine blanking. Too high forming force increases the load of the die and greatly increases the risk of die failure. If the forming force is reduced, the material will fracture prematurely, which will lead to poor quality parts. Aiming at this problem, a new force variation load fine-blanking technology is proposed in this paper. During the loading process, the forming force does not remain constant but changes with the blanking stroke. A 2D finite element fine-blanking model was established for the TC4 material. The mechanism of force variation fine blanking is also revealed. This paper proposes a method to design the loading route of the forming force with variable load. This method combines finite element simulation with neural network and a multi-objective genetic algorithm. Finally, the application of variable load fine blanking production and the application of traditional fine blanking production parts are verified by the experimental method. The same results are obtained from both simulation and experiment. It is found that the variable load fine blanking process can greatly reduce the load of the die on the premise of ensuring the quality of fine-blanking parts.