Phospholipid Complex Technique for Superior Bioavailability of Phytoconstituents

From these results it can be understood that plant extract showing its pharmacological action on diabetes between the time intervals of 1-2 hr after its administration. This is exactly what the action that is being observed from the standard Glibenclamide group which also shown its action at its 1-2 hr of administration to the animals. Here the statistically significant action of the higher dose of plant extract can be compared with that of the standard Glibenclamide group. From these results it can be understood that the plant extract is capable of inhibiting the elevation of blood glucose level to the extent of the action that has been shown by the standard Glibenclamide group. Particularly at the time interval of 2-4 hr both the Glibenclamide and plant extract at its high dose group that is 400 mg/kg has been significantly inhibited the elevation of the blood glucose levels in the animals.DOI: http://dx.doi.org/10.3329/icpj.v2i3.13581 International Current Pharmaceutical Journal, February 2013, 2(3): 53-56

Aim: The aim of this study was to simultaneously enhance the solubility and stability of bacogenins hydrolyzed bacoside rich extract by a ternary system comprised of hydrogenated soy lecithin and a third auxiliary substance, fulvic acid.Method: Both ternary and binary complexes were prepared using the solvent evaporation method were characterized by Fourier transform infrared technique, differential scanning calorimeter and scanning electron microscope. The entrapment efficacy in both binary and ternary system was calculated and the effect on the solubility, dissolution and stability of bacogenins was found out. Furthermore, the prepared complexes were subjected to behavioural pharmacological studies.Results : FTIR, DSC, and SEM studies in totality confirmed the formation of binary and ternary complexes. Enhancement in solubility was observed, and the order of release characteristics was found to be BHFS> BHSL>BHF> BH when the dissolution studies were carried out in 40% aqueous solution of ethanol. A significant improvement in the memory and antioxidant capacity was noticed in both binary, ternary complexes and fulvic acid treatment groups.Conclusion: The results revealed that the ternary complex could be a promising drug delivery system to improve the oral bioavailability of the bacogenins.

Humic substances are not new to mankind. These straw-colored organic acids, primarily derived from soil humus and plants, with hydrophobic core and hydrophilic exterior, are used as raw materials (such as shilajit, peat, etc.) for oral and topical applications since antiquity, as mentioned in the text of indigenous medicines. With the advancement of science, different components (humic acid and fulvic acid) are isolated, characterized, and evaluated for physicochemical and pharmacological properties. Despite possessing unique properties, their exploitation for healthcare purposes hasn’t been competitive. They are primarily present in the dietary supplement category of products, despite having the potential to be explored in therapeutic categories. Major impediments to their growth and scientific or regulatory solutions are discussed in detail in this manuscript. A comprehensive survey of different products available in the texts of indigenous medicines and the marketed products are also included. The clinical trials and patents on the topic give an idea about the ongoing investigations. This review aims to explore the multifaceted roles of HS in promoting human health, particularly focusing on recent innovations in the fields of nutraceuticals, pharmaceuticals, and cosmetic products. Overall, it is concluded that HS has achieved great success in irrigation as fertilizer and for soil health, and it has different pharmacological or therapeutic potentials for human health.

The aim of the project was to investigate Peat-derived Fulvic acid for its propensity to form co-crystals with quercetin and curcumin and characterize it by using different analytical techniques. The formation of co-crystals generally enhances water solubility and the overall bioavailability of molecules. Co-crystals were synthesized using a 1:1 stoichiometric ratio of fulvic acid with quercetin and curcumin, respectively, using solvent crystallization techniques taking tetrahydrofuran and water in a 1:1 v/v ratio. The co-crystals were characterized by spectroscopic methods, FTIR and Differential scanning calorimetry. Further confirmation was made by morphological studies using SEM. A structural analysis was also carried out, using ¹³C solid-state NMR analysis. The studies confirmed the formation of semi crystalline forms. Furthermore, the saturation solubility displayed the enhancement in solubility of up to 10, 5-folds for Quercetin and Curcumin, respectively. The in vitro dissolution results showed that T50% was achieved within 30 min for both the drugs. The literature supports that the nutraceutical co-crystals offer advantages, particularly in the improvement of biopharmaceutical properties and addressing the challenges of the lab and manufacturing scale process. Both the semi crystalline powders exhibited enhanced solubility and a better dissolution profile.