Biser Makelov

Dr. Biser Makelov

Department of Special Surgery, Trakia University, Stara Zagora, Bulgaria
orcid
MD,Ph.D

Research Focus & Metrics

Academic Career Length

7Years (2020-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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28 January 2023 in Medicina
Verified
Journal Article
Open access
PDF file
SSSelim Safalı
Selim Safalı
TBTill Berk
Till Berk
Biser MakelovBiser Makelov
Biser Makelov
MAMehmet Ali Acar
Mehmet Ali Acar
Boyko GueorguievBoyko Gueorguiev
Boyko Gueorguiev
HPHans-Christoph Pape
Hans-Christoph Pape
Background and Objectives: Following the most recent software and 3D printing developments, the use of personalized 3D printed orthopedic implants for treatment of complicated surgical cases has gained more popularity. Today, orthopedic problems that cannot be solved with standard implants may be effectively addressed using personalized prostheses. The aim of this study is to present the designing, modeling and production stages of four different personalized 3D printed prostheses and their application in clinical cases of patients who underwent treatment in various anatomical locations with a precisely specified indication for implantation. Materials and Methods: Based on computed tomography scanning, personalized 3D printed prostheses were designed, produced and used in four patients within a period of three to five days after injury or admission. Results: Early term follow-ups demonstrated good to excellent results. Conclusions: Personalized 3D printed prostheses offer an opportunity for a treatment of choice and provide good anatomical and functional results, shortened surgical time, less complications, and high satisfaction in patients with appropriate indications. The method should be considered primarily for patients with large bone defects, or such indicated for resection. Personalized 3D printed prostheses have the potential to become more common and beneficial in the future.

7 March 2022 in European Journal of Trauma and Emergency Surgery
Verified
Journal Article
Closed access
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SIStoyan Ivanov
Stoyan Ivanov
ASAleksandar Stefanov
Aleksandar Stefanov
IZIvan Zderic
Ivan Zderic
CRChristian Rodemund
Christian Rodemund
TSTim Schepers
Tim Schepers
Boyko GueorguievBoyko Gueorguiev
Boyko Gueorguiev

6 July 2020 in Journal of Hand and Microsurgery
Verified
Journal Article
Closed access
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TJTerrence Jose Jerome
Terrence Jose Jerome
FMFrancisco Mercier
Francisco Mercier
CMChaitanya S. Mudgal
Chaitanya S. Mudgal
JAJoan Arenas-Prat
Joan Arenas-Prat
GVGustavo Vinagre
Gustavo Vinagre
VAVineet Abraham
Vineet Abraham
With a lot of uncertainty, unclear, and frequently changing management protocols, COVID-19 has significantly impacted the orthopaedic surgical practice during this pandemic crisis. Surgeons around the world needed closed introspection, contemplation, and prospective consensual recommendations for safe surgical practice and prevention of viral contamination. One hundred orthopaedic surgeons from 50 countries were sent a Google online form with a questionnaire explicating protocols for admission, surgeries, discharge, follow-up, relevant information affecting their surgical practices, difficulties faced, and many more important issues that happened during and after the lockdown. Ten surgeons critically construed and interpreted the data to form rationale guidelines and recommendations. Of the total, hand and microsurgery surgeons (52%), trauma surgeons (32%), joint replacement surgeons (20%), and arthroscopy surgeons (14%) actively participated in the survey. Surgeons from national public health care/government college hospitals (44%) and private/semiprivate practitioners (54%) were involved in the study. Countries had lockdown started as early as January 3, 2020 with the implementation of partial or complete lifting of lockdown in few countries while writing this article. Surgeons (58%) did not stop their surgical practice or clinics but preferred only emergency cases during the lockdown. Most of the surgeons (49%) had three-fourths reduction in their total patients turn-up and the remaining cases were managed by conservative (54%) methods. There was a 50 to 75% reduction in the number of surgeries. Surgeons did perform emergency procedures without COVID-19 tests but preferred reverse transcription polymerase chain reaction (RT-PCR; 77%) and computed tomography (CT) scan chest (12%) tests for all elective surgical cases. Open fracture and emergency procedures (60%) and distal radius (55%) fractures were the most commonly performed surgeries. Surgeons preferred full personal protection equipment kits (69%) with a respirator (N95/FFP3), but in the case of unavailability, they used surgical masks and normal gowns. Regional/local anesthesia (70%) remained their choice for surgery to prevent the aerosolized risk of contaminations. Essential surgical follow-up with limited persons and visits was encouraged by 70% of the surgeons, whereas teleconsultation and telerehabilitation by 30% of the surgeons. Despite the protective equipment, one-third of the surgeons were afraid of getting infected and 56% feared of infecting their near and dear ones. Orthopaedic surgeons in private practice did face 50 to 75% financial loss and have to furlough 25% staff and 50% paramedical persons. Orthopaedics meetings were cancelled, and virtual meetings have become the preferred mode of sharing the knowledge and experiences avoiding human contacts. Staying at home, reading, and writing manuscripts became more interesting and an interesting lifestyle change is seen among the surgeons. Unanimously and without any doubt all accepted the fact that COVID-19 pandemic has reached an unprecedented level where personal hygiene, hand washing, social distancing, and safe surgical practices are the viable antidotes, and they have all slowly integrated these practices into their lives. Strict adherence to local authority recommendations and guidelines, uniform and standardized norms for admission, inpatient, and discharge, mandatory RT-PCR tests before surgery and in selective cases with CT scan chest, optimizing and regularizing the surgeries, avoiding and delaying nonemergency surgeries and follow-up protocols, use of teleconsultations cautiously, and working in close association with the World Health Organization and national health care systems will provide a conducive and safe working environment for orthopaedic surgeons and their fraternity and also will prevent the resurgence of COVID-19. Publication Date: 06 July 2020 (online) © 2020. Society of Indian Hand & Microsurgeons. This article is published by Thieme. Thieme Medical and Scientific Publishers Pvt. Ltd. A-12, Second Floor, Sector -2, NOIDA -201301, India

17 February 2023 in Journal of Clinical Medicine
Verified
Journal Article
Open access
PDF file
Biser MakelovBiser Makelov
Biser Makelov
DMDominic Mischler
Dominic Mischler
PVPeter Varga
Peter Varga
TATheerachai Apivatthakakul
Theerachai Apivatthakakul
JFJames Fletcher
James Fletcher
Boyko GueorguievBoyko Gueorguiev
Boyko Gueorguiev
(1) Background: Unstable meta-diaphyseal tibial fractures represent a heterogeneous group of injuries. Recently, good clinical results have been reported when applying a technique of externalized locked plating in appropriate cases, highlighting its advantage in terms of less additional tissue injury compared with conventional methods of fracture fixation. The aims of this prospective clinical cohort study were, firstly, to investigate the biomechanical and clinical feasibility and, secondly, to evaluate the clinical and functional outcomes of single-stage externalized locked plating for treatment of unstable, proximal (intra- and extra-articular) and distal (extra-articular), meta-diaphyseal tibial fractures. (2) Methods: Patients, who matched the inclusion criteria of sustaining a high-energy unstable meta-diaphyseal tibial fracture, were identified prospectively for single-stage externalized locked plating at a single trauma hospital in the period from April 2013 to December 2022. (3) Results: Eighteen patients were included in the study. Average follow-up was 21.4 ± 12.3 months, with 94% of the fractures healing without complications. The healing time was 21.1 ± 4.6 weeks, being significantly shorter for patients with proximal extra- versus intra-articular meta-diaphyseal tibial fractures, p = 0.04. Good and excellent functional outcomes in terms of HSS and AOFAS scores, and knee and ankle joints range of motion were observed among all patients, with no registered implant breakage, deep infection, and non-union. (4) Conclusions: Single-stage externalized locked plating of unstable meta-diaphyseal tibial fractures provides adequate stability of fixation with promising clinical results and represents an attractive alternative to the conventional methods of external fixation when inclusion criteria and rehabilitation protocol are strictly followed. Further experimental studies and randomized multicentric clinical trials with larger series of patients are necessary to pave the way of its use in clinical practice.
1

10 April 2023 in Medicina
Verified
Journal Article
Open access
PDF file
TBTill Berk
Till Berk
IZIvan Zderic
Ivan Zderic
JCJan Caspar
Jan Caspar
PSPeter Schwarzenberg
Peter Schwarzenberg
TPTorsten Pastor
Torsten Pastor
Boyko GueorguievBoyko Gueorguiev
Boyko Gueorguiev
Background and Objectives: Pubic ramus fractures are common in compound pelvic injuries known to have an increased rate of morbidity and mortality along with recurrent and chronic pain, impeding a patient’s quality of life. The current standard treatment of these fractures is percutaneous screw fixation due to its reduced risk of blood loss and shorter surgery times. However, this is an intricate surgical technique associated with high failure rates of up to 15%, related to implant failure and loss of reduction. Therefore, the aim of this biomechanical feasibility study was to develop and test a novel intramedullary splinting implant for fixation of superior pubic ramus fractures (SPRF), and to evaluate its biomechanical viability in comparison with established fixation methods using conventional partially or fully threaded cannulated screws. Materials and Methods: A type II superior pubic ramus fracture according to the Nakatani classification was created in 18 composite hemi-pelvises via a vertical osteotomy with an additional osteotomy in the inferior pubic ramus to isolate the testing of three SPRF fixation techniques performed in 6 semi-pelvises each using either (1) a novel ramus intramedullary splint, (2) a partially threaded ramus screw, or (3) a fully threaded ramus screw. Results: No significant differences were detected among the fixation techniques in terms of initial construct stiffness and number of cycles to failure, p ≥ 0.213. Conclusion: The novel ramus intramedullary splint can be used as an alternative option for treatment of pubic ramus fractures and has the potential to decrease the rate of implant failures due to its minimally invasive implantation procedure.
1

3 June 2024 in Trakia Journal of Sciences
Verified
Journal Article
Open access
PDF file
Biser MakelovBiser Makelov
Biser Makelov
Purpose. This technical note describes a minimally invasive surgical technique for early appropriate care in patients with high-energy, multifragmentary tibial fractures by means of safe one-stage external stabilization with angle-stabled plates. The purpose of the presented prospective case series study was, to explore the clinical feasibility and research the biomechanical parameters and of externalized locked plating and, to test the functional result and clinical outcomes following the novel technique for definitive surgical treatment for complex - meta-diaphyseal multifragmentary, proximal (with simple intra-articular) and distal (multifragmentary metaphyseal), fractures of the shin bone. Methods: Thirty-three patients participated in the prospective feasibility study, carried out from August 2012 to September 2023. The precise inclusion criteria were: sustained high-energy tibial trauma and severe soft tissue injury, with complex proximal and distal meta-diaphyseal tibial fractures, stabilized with externalized locked plating. Results: Eighteen of the patients from the prospective cohort included in the study were followed up for an average of 21.4 ± 12.3 months, union rate of 94,7%. All fractures healed by means of secondary bone union and with minor complications. We reached a significantly shorter mean union time was 21.1 ± 4.6 weeks, for patients with proximal extra- versus intra-articular meta-diaphyseal tibial fractures, p = 0.04. According to HSS and AOFAS scores, good and excellent functional results in knee and ankle joints’ range of motion were accomplished among 90 percents of the patients. However, there were no registered implant de-bricolage, non-union or severe deep infection. We had two patients with re-fracture between the fourth and sixth week after external plate removal, who underwent secondary surgical procedure for successful bone healing. Several screws were loosened in nine patients from the cohort, with no negative effect on the bone union process. Conclusions. The currently reported technique for one–stage supercutaneous fracture stabilization by means of externalized locked plating is a novel surgical procedure for a safe external fracture fixation with LISS-DF plate. The definitive externalized fracture plating is a viable surgical solution for natural bone union in complex – multifragmentary meta-diaphyseal tibial fractures with injured soft tissue envelope.