Frederik Greve

Dr. Frederik Greve


Research Focus & Metrics

Academic Career Length

11Years (2016-Present)

(Calculated once Scilit publication data is synced: current year − year of first publication + 1)

Representative Publications

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Michael MüllerMichael Müller
Michael Müller
AGAlexander Gutwerk
Alexander Gutwerk
FGFrederik Greve
Frederik Greve
LVLisa Völker
Lisa Völker
MZMichael Zyskowski
Michael Zyskowski
KBKarl Braun
Karl Braun
Background: Fractures of the proximal femur constitute daily work in orthopedic trauma surgery. With the continuous increase of obesity in the general population, surgeons face several known technical challenges. The aim of this study was to investigate the association of high body mass index (BMI) in patients with proximal femur fractures with intra- and postoperative adverse events, as well as with functional outcomes after successful surgery. Methods: In this retrospective, single-center cohort study, 950 patients who sustained a fracture of the proximal femur (femoral neck fracture or trochanteric fracture) and underwent surgical treatment at our level I trauma center between 2003 and 2015 were included. Patient-specific data were obtained in regard to demographics, comorbidities, and fracture morphology. In-hospital postoperative complications (i.e., need for revision surgery, wound site infection, pneumonia, urinary tract infection, necessary transfusion, and deep-vein thrombosis) were analyzed, along with the length of hospitalization and overall mortality rate. Functional outcome was assessed using the Barthel index and the patient’s ability to walk on crutches. Mortality rate and need for revision surgery were assessed over a two-year time period. Any adverse event was correlated to one of the four WHO’s BMI groups. Results: The cohort included 80 (8.4%) underweight patients, 570 (60.0%) normal weight patients, 241 (25.4%) overweight patients, and 59 (6.2%) obese patients. We found more femoral neck fractures (506, or 53%) than trochanteric fractures (444, or 47%). In bivariate analysis, no significant difference was found in regard to overall mortality or postoperative complications. Hospitalization time (LOS) differed between the underweight (12.3 ± 4.8 days), normal (13.6 ± 7.8 days), overweight (14.2 ± 11.7 days), and obese patients (16.0 ± 9.7 days) (p = 0.040). Operation time increased stepwise with increasing BMI: underweight = 85.3 ± 42.9 min; normal weight = 90.2 ± 38.2 min; overweight = 99.9 ± 39.9 min; obese = 117.2 ± 61.5 min (p < 0.001). No significant difference was found by analyzing functional outcomes. However, patients with intermediate BMI levels (18.5–30 kg/m2) tended to achieve the best results, as represented by a higher Barthel index score and the patient’s ability to walk on crutches. Conclusion: Increased BMI in patients with proximal femur fractures is associated with both longer operation time and length of hospitalization (LOS). Postoperative mobilization and functional outcomes appear to follow a reversed J-curve distribution (with overweight patients showing the best functional results), whereas both obese and underweight patients have associated poorer function.

19 July 2018 in Journal of Neurochemistry
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ASAnne Sebastiani
Anne Sebastiani
FGFrederik Greve
Frederik Greve
CGChristina Gölz
Christina Gölz
CFCarola Y. Förster
Carola Y. Förster
HKHermann Koepsell
Hermann Koepsell
STSerge C. Thal
Serge C. Thal

21 August 2020 in BMC Musculoskeletal Disorders
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FGFrederik Greve
Frederik Greve
KKKarl-Georg Kanz
Karl-Georg Kanz
MZMichael Zyskowski
Michael Zyskowski
FMFrancesca von Matthey
Francesca von Matthey
PBPeter Biberthaler
Peter Biberthaler
SHStefan Huber-Wagner
Stefan Huber-Wagner
Background: Foehn describes a wind which occurs in areas with close proximity to mountains. The presence of foehn wind is associated with worsening health conditions. This study analyzes the correlation between a foehn typical circulation and the incidence for suffering a severe trauma. Methods: This is a retrospective, multicentre observational register study. The years from 2013 to 2016 were analyzed for the presence of foehn winds. A logistic regression analysis with the number of daily admitted trauma patients as the primary target value was performed in dependence of foehn winds. Southern Bavaria is a typical foehn wind region. Individuals were treated in 37 hospitals of Southern Bavaria which participate in the TraumaRegister DGU®, an international register that includes all severe trauma patients, mainly in Germany. We analyzed patients with an Injury Severity Score (ISS) of at least nine with admission to intensive care units or prior death in the emergency room. Results: 6215 patients were enrolled in this study. A foehn-typical circulation was present on 65 days (4.5%). 301 patients (5%) suffered a trauma with an ISS ≥ 9 on a foehn day. The mean ISS was 20.2 (9–75). On average, 4.3 patients (0–15 patients) were admitted on a daily basis due to a severe trauma. The multivariate regression analysis revealed a daily increase of 0.87 individuals (p = 0.004; 95% CI 0.23–1.47) on foehn days. During spring 1.07 patients (p = < 0.001; 95% CI 0.72–1.42), in summer 1.98 patients (p = < 0.001; 95% CI 1.63–2.32), in fall 0.63 (p = < 0.001; 95% CI 0.28–0.97) and on Saturdays, 0.59 patients (p = < 0.001; 95% CI 0.24–0.93) were additionally admitted due to severe trauma. Conclusion: Foehn winds are significantly associated with severe trauma in trauma centers of the TraumaNetzwerk DGU®.

2 December 2022 in Journal of Clinical Medicine
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MZMichael Zyskowski
Michael Zyskowski
MWMarkus Wurm
Markus Wurm
FGFrederik Greve
Frederik Greve
PZPhilipp Zehnder
Philipp Zehnder
PPPatrick Pflüger
Patrick Pflüger
Chlodwig KirchhoffChlodwig Kirchhoff
Chlodwig Kirchhoff
(1) Background: As age in western populations is rising, so too are fractures, e.g., of the distal fibula. The aim of this study was to find out whether a novel, minimally invasive intramedullary osteosynthesis technique for the treatment of distal fibula fractures in elderly patients results in not only a reduction of postoperative complications, but also a shorter hospitalization time, an improved clinical outcome, and preserved autonomy in geriatric trauma patients. (2) Methods: In this prospective study, the results following surgical treatment for distal fibula fractures in geriatric patients after using DePuy Synthes® one-third semitubular plate (Group I) or a minimally invasive intramedullary photodynamic Bone StabilizationSystem (IlluminOss®) (Group II) were compared at 6 weeks, 12 weeks, 6 months, and 1 year after initial treatment. (3) Results: Significant improvement regarding clinical outcome was shown in Group II 6 and 12 weeks after surgery. (4) Conclusions: Our study results demonstrate that the use of this new intramedullary stabilization system in combination with an immediate postoperative weight bearing seems to be a safe and stable treatment option for ankle fractures in geriatric patients, especially in the early stages of recovery.

28 September 2018 in European Journal of Medical Research
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FGFrederik Greve
Frederik Greve
KBKarl Braun
Karl Braun
VVVeronika Vitzthum
Veronika Vitzthum
MZMichael Zyskowski
Michael Zyskowski
Michael MüllerMichael Müller
Michael Müller
MBMarc Beirer
Marc Beirer
There are many approved patient-related outcome measurement tools regarding ankle pathologies. However, there is none incorporating the range of motion (ROM) as an objective parameter. Most instruments focus on subjective parameters such as pain and impairment at work or daily living. Furthermore, the majority is only applicable to a specific pathology. Therefore, the objective of our study was to develop and validate the Munich Ankle Questionnaire (MAQ) as a universal self-assessment score including subjective and objective items. The established McGuire Score, Bray Score, Ankle Hindfoot Score (AOFAS) and Olerud and Molander Score were analyzed for relevant items and subscales. Items of interest were then condensed and allocated to the respective subscales of the MAQ. The final MAQ consists of 6 items addressing general and demographic data and 12 items addressing three domains: pain (3 items), work and daily living (5 items), movement and ROM (4 items). The evaluation of validity, reliability and responsiveness of the MAQ was performed in a prospective clinical study including traumatic as well as degenerative ankle pathologies. In total, 148 patients (79 female, 69 male, median age 45 years) were included in the validation study. With intra-class correlation coefficients of at least 0.77, test–retest reliability was proven. Construct validity with a correlation coefficient of 0.82 and responsiveness with a correlation coefficient ranging from 0.42 to 0.47 were confirmed. The MAQ is a reliable and valid self-assessment measurement tool for the follow-up examination regarding subjective and objective parameters of traumatic and degenerative ankle pathologies. The MAQ has no limitation to specific disorders and allows a broad application.

9 February 2019 in Injury
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FGFrederik Greve
Frederik Greve
MBM. Beirer
M. Beirer
MZM. Zyskowski
M. Zyskowski
MCM. Crönlein
M. Crönlein
MMM. Müller
M. Müller
Chlodwig KirchhoffChlodwig Kirchhoff
Chlodwig Kirchhoff