Social responsibility plays an important role in the sustainable development of major municipal road infrastructure. In this study, a major municipal road infrastructure social responsibility (MMRISR) evaluation indicator system is developed for the comprehensive evaluation of social responsibility. Questionnaires and expert interviews were used to screen the initial indicators of the proposed system. Then, 24 indicators were selected from four dimensions to establish an MMRISR evaluation indicator system. The fuzzy analytic hierarchy process was employed to calculate the weights of each indicator. Finally, the Zhengzhou 107 Auxiliary Road Project was adopted as a case study to test the reliability of the proposed evaluation system. The contribution of this study lies in the provision of a novel indicator system for the social responsibility evaluation of major municipal road infrastructures, thus improving the science of project establishment and decision-making. The proposed social responsibility system can provide an efficient decision-making tool for social responsibility governance, fundamentally promoting the sustainable development of major municipal road infrastructures and the achievement of certain sustainable development goals.