A series of novel oxazole derivatives (A, A1, A2) were synthesized starting from acetone and urea. The compound (A) was obtained by heating it with acetophenone and urea in iodine. Compound (A) on treatment with 4-amino benzaldehyde (Z)-N-(4-amino benzylidine)-4-((E)-Penta-2, 4-diene-2) oxazole-2-amine afforded (A1). Acylation of compound (A) with 4-amino benzoyl chloride to obtain the corresponding N-(4 phenyl oxazole-2- yl)- benzamide (A2). The structures of compounds have been established employing FTIR and 1H-NMR spectral analysis. All oxazole derivatives were evaluated for anti-inflammatory activity by the carrageenan-induced Rat hind paw method. Derivative A1 shows maximum anti-inflammatory activity. Keywords: Oxazoles, anti-inflammatory, Benzamide, acetophenone, indomethacin.

Desmodium gangeticum belongs to family Leguminoceae. It is a versatile plant with many features and considerable prospective. Whole plant is employed as traditional medicine for the treatment of several disorders. D. gangeticum is a traditional Ayurvedic plant used for centuries as an anthelminthic, anti-catarrahal, diuretic, expectorant, astrin-gent, febrifuge, nervine tonic, anti diarrheal, bronchodilator, vasopressor, analgesic, antipyretic, cardio tonic, stimulant, antioxidant and anti-inflammatory agent. Chromatographic fingerprint and similarity measurement could efficiently identify and distinguish between root and small branches of D. gangeticum. The phytochemical fingerprint profiling of root and small branches of D. gangeticum were found similar as an official part of D. gangeticum plant i.e. root, therefore small branches may be used in place of root and vice-versa after comparison and confirmation of same pharmacological activities.

Polycystic ovary syndrome (PCOS), also known as Stein-Leventhal Syndrome, was first described in 1935. PCOS, which may also be referred to as polycystic ovary disease is the most common hormonal disorder found in premenopausal women. PCOS is the most common endocrine disorder in women of reproductive age and is the most common cause of infertility due to ovulation. A PCOS is an endocrine disorder which affects the adolescent girls. A PCOS is a condition in which a woman has an imbalance of female sex hormones. This may lead to changes in the menstrual cycle, cyst in the ovary, failure to conceive, and other health problems. It is a common health problem among teenagers and young women. It affects 5–10% of women in their reproductive years. These problems cause infertility. Two principal components to diagnose this syndrome are menstrual dysfunction and clinical or laboratory hyperandrogenism in which these items are used in clinical diagnosis. PCOS is a hormonal disorder that affects between 5% and 10% of women of reproductive age and remains the most enigmatic reproductive disorders. The most common symptoms of PCOS are obesity, acne, amenorrhea, irregular menstrual cycles, hirsutism, insulin resistance (IR), and high cholesterol. Due to the varied nature of PCOS and the large range of possible signs and symptoms, health personnel need a thorough knowledge of the disorder and its management. It is a major disorder characterized by elevated levels of male hormones (androgens), acne, and hirsutism. It can even cause IR, anovulation, and infertility on prolonging incidence of cysts. One of the treatments for PCOS is the use of synthetic medicine, which can help to treat PCOS but with side effects. However, many women who suffer from PCOS opt to use alternative medicine in conjunction with traditional medicine to improve their condition. There are some herbs that are very helpful in treating PCOS. Since PCOS is a curable disorder, it can be cured by the use of natural remedies or allopathic medication. There is a growing interest in herbal remedies or allopathic medication to cure the PCOS. There is a need to change the lifestyle management, diet to control the PCOS level. The natural remedies include treatment with phytoestrogenic and non-estrogenic herbs such as Licorice, Ginseng, Black cohosh, Dong, soy, evening primrose, honey, fenugreek, Schisandra root, and many other which are effective and safe. Many plants have been highly esteemed sources and have advantages which reduce PCOS and also having a hypoglycemic effect. In this review, an attempt has been made to study the use of natural remedy for the treatment of PCOS.

Antioxidant play an important role to protect damage caused oxidative stress (OS).Chlorophyll having phenolic contents are reported to possess antioxidant properties. The present study was designed to investigate the antioxidant properties of methanolic solution from Super Chlorophyll. Objective: The main objective of the study was to evaluate the antioxidant activity of the chlorophyll in different validated in vitro models. Methods: The antioxidant activities of methanolic solution were evaluated by in vitro standard method using UV-Spectrophotometer. The antioxidant activity were determined bt total antioxidant capacity, DPPH (1-1-diphennyl-2-picrylhydrzine) radical scavenging assay, Nitric Oxide scavenging assay and Hydrogen Peroxide scavenging assay methods. Result: The solution of Chlorophyll was studied for antioxidant potential. Ascorbic acid was used as standard. This method is simple and activity of the solution is reported in term of IC50 value. Antioxidant properties depend on the IC50 value. Lesser the IC50 value, more is the antioxidant activity. Chlorophyll showed good antioxidant activity. Conclusion: In case of in vitro antioxidant activity, Chlorophyll scavenged DPPH, hydrogen peroxide, nitric oxide radicals significantly, showed IC50 values near to standard ascorbic acid, thus proving to have good antioxidant potential. Keywords: Oxidative stress, DPPH, Antioxidant, Super chlorophyll.

Diabetes prevalence has increased dramatically in almost every part of the world in recent decades. The increased number of persons with diabetes or those who have had diabetes for a longer period is anticipated to change the disease profile in many communities throughout the world, owing to a higher frequency of diabetes-specific comorbidities such as kidney failure and peripheral artery disease. The epidemiology of other illnesses commonly linked with diabetes, such as infections and cardiovascular disease, may also shift, with significant consequences for the quality of life, healthcare needs, and economic expenditures. Diabetes (DM) is becoming more common at an alarming pace throughout the world. According to the International Diabetes Federation, an estimated 415 million individuals worldwide suffered from this illness in 2015. Diabetes complications include increased morbidity, disability, and death, posing a danger to the economies of all countries, particularly emerging ones. The current understanding of the global burden and variance in diabetes-related complications is inadequate. According to the available statistics, rates of myocardial infarction, stroke, and amputation are falling among diabetics, coinciding with lower mortality. However, the majority of these statistics originate from research conducted in only a few high-income nations. Other diabetic consequences, such as end-stage renal disease, retinopathy, and cancer, have received less attention. Obesity, insulin resistance, hyperglycemia, and hyperlipidemia are all variables that influence the development and progression of diabetes problems. In this review, we have included all the major complications and their pathophysiology along with their possible mechanism of action and the possible treatment with herbal or medicinal plants. This review will explore new ways of the diabetic complications around the globe.