Business process re-engineering (BPR) is an approach to improving organizational performance. It evolved mostly within the private sector to maintain a successful business model despite increasing global competition. BPR presents a fundamental improvement in the essential organizational design. This paper investigates recent studies of BPR and identifies the success factors of BPR projects and their connection to the human–technology–organization (HTO) framework. By examining the relevant literature, we study various factors and their effects on the implementation of BPR and how these factors can affect process performance, successfully or otherwise. The aim is to study the literature to determine the success factors and challenges for BPR in the HTO framework. The article concludes by emphasizing the factors that will help to allow BPR to be implemented with a wider use in different sectors.