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Prof. Dr. min xu
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Academic Career Length
11Years (2016-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
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Journal Article
XSXiaojuan Sun
Xiaojuan SunHDHongbo Deng
Hongbo DengTSTengyun Shu
Tengyun ShuMXmin xu
min xuLSLi-Hua Su
Li-Hua SuHLHaizhou Li
Haizhou LiPanax notoginseng (Burk.) F. H. is a genuine medicinal material in Yunnan Province. As accessories, P. notoginseng leaves mainly contain protopanaxadiol saponins. The preliminary findings have indicated that P. notoginseng leaves contribute to its significant pharmacological effects and have been administrated to tranquilize and treat cancer and nerve injury. Saponins from P. notoginseng leaves were isolated and purified by different chromatographic methods, and the structures of 1–22 were elucidated mainly through comprehensive analyses of spectroscopic data. Moreover, the SH-SY5Y cells protection bioactivities of all isolated compounds were tested by establishing L-glutamate models for nerve cell injury. As a result, twenty-two saponins, including eight dammarane saponins, namely notoginsenosides SL1-SL8 (1–8), were identified as new compounds, together with fourteen known compounds, namely notoginsenoside NL-A3 (9), ginsenoside Rc (10), gypenoside IX (11), gypenoside XVII (12), notoginsenoside Fc (13), quinquenoside L3 (14), notoginsenoside NL-B1 (15), notoginsenoside NL-C2 (16), notoginsenoside NL-H2 (17), notoginsenoside NL-H1 (18), vina-ginsenoside R13 (19), ginsenoside II (20), majoroside F4 (21), and notoginsenoside LK4 (22). Among them, notoginsenoside SL1 (1), notoginsenoside SL3 (3), notoginsenoside NL-A3 (9), and ginsenoside Rc (10) showed slight protective effects against L-glutamate-induced nerve cell injury (30 µM).
28 June 2023 in ACS Applied Materials & Interfaces
Journal Article
BWBaoqu Wang
Baoqu Wang
XTXiaoxue Tian
Xiaoxue Tian
XLXing-Cng Li
Xing-Cng LiKCKui Cheng
Kui ChengMXmin xu
min xu15 July 2022 in Protein & Cell
Journal Article
DZDaming Zuo
Daming ZuoYCYu Chen
Yu Chen
JCJian-Piao Cai
Jian-Piao Cai
HYHao-Yang Yuan
Hao-Yang Yuan
JWJun-Qi Wu
Jun-Qi Wu
MXmin xu
min xu +13
The twenty-first century has already recorded more than ten major epidemics or pandemics of viral disease, including the devastating COVID-19. Novel effective antivirals with broad-spectrum coverage are urgently needed. Herein, we reported a novel broad-spectrum antiviral compound PAC5. Oral administration of PAC5 eliminated HBV cccDNA and reduced the large antigen load in distinct mouse models of HBV infection. Strikingly, oral administration of PAC5 in a hamster model of SARS-CoV-2 omicron (BA.1) infection significantly decreases viral loads and attenuates lung inflammation. Mechanistically, PAC5 binds to a pocket near Asp49 in the RNA recognition motif of hnRNPA2B1. PAC5-bound hnRNPA2B1 is extensively activated and translocated to the cytoplasm where it initiates the TBK1-IRF3 pathway, leading to the production of type I IFNs with antiviral activity. Our results indicate that PAC5 is a novel small-molecule agonist of hnRNPA2B1, which may have a role in dealing with emerging infectious diseases now and in the future.
20 March 2024 in Journal of Hazardous Materials
Journal Article
2 December 2021 in Chemistry & Biodiversity
Journal Article
SCShu‐Xia Chen
Shu‐Xia Chen
JXJia‐Yao Xiang
Jia‐Yao Xiang
JHJia‐Xin Han
Jia‐Xin Han
YFYang‐ Feng
Yang‐ Feng
HLHai‐Zhou Li
Hai‐Zhou Li
MXmin xu
min xu +1
About Me
Min Xu, Professor.
2016-Present: Faculty of Life Sciences and Technology, Kunming University of Science and Technology, Professor, PhD Supervisor.
2011-2015: Kunming Institute of Botany, Chinese Academy of Sciences, Associate Researcher.
2010-2011: Kunming Institute of Botany, Chinese Academy of Sciences, Assistant Research Fellow.
2008-2009: Griffith University, Australia, Research fellow.
2007-2008: Institute of Natural Products Chemistry, French National Academy of Sciences, Postdoctoral Fellow.
2002-2007: Kunming Institute of Botany, Chinese Academy of Sciences, PhD in Botany.
1995-1999: Yunnan University of Chinese Medicine, Bachelor in Traditional Chinese Medicine.
Research direction: Research on anti-hepatitis B virus activity and neurological activity of natural small molecules and their mechanisms of action, providing new strategies for the treatment of difficult-to-heal diseases; re-evaluation of the material basis of ethnic medicine in Yunnan Province; research on the development and utilization of aromatic plant resources and the basis of their "aromatic" medicinal properties.
Honors: Head of Innovation Team of Natural Medicines Chemical Biology, Yunnan Provincial Department of Education in 2019.
Academic Young and Blue Talents of Kunming University of Technology in 2017.
Third Prize of Natural Science of Yunnan Province in 2016.
2014 – Present: Executive Director of the Chinese Society of Ethnomedicine, Medicinal Resources Branch.