'%3e%3cpath%20d='M29.5529%2025.4577C28.9763%2024.0918%2028.1395%2022.8511%2027.0891%2021.8047C26.0419%2020.7553%2024.8014%2019.9186%2023.4361%2019.3408C23.4239%2019.3347%2023.4116%2019.3317%2023.3994%2019.3256C25.3039%2017.95%2026.5419%2015.7092%2026.5419%2013.1812C26.5419%208.99325%2023.1487%205.6001%2018.9608%205.6001C14.7729%205.6001%2011.3797%208.99325%2011.3797%2013.1812C11.3797%2015.7092%2012.6177%2017.95%2014.5222%2019.3286C14.51%2019.3347%2014.4977%2019.3378%2014.4855%2019.3439C13.116%2019.9216%2011.8871%2020.7501%2010.8325%2021.8078C9.78311%2022.8549%208.94642%2024.0954%208.36866%2025.4607C7.80106%2026.7974%207.49494%2028.2304%207.46687%2029.6823C7.46606%2029.7149%207.47178%2029.7474%207.4837%2029.7778C7.49563%2029.8082%207.51351%2029.8358%207.5363%2029.8592C7.55909%2029.8826%207.58633%2029.9011%207.6164%2029.9138C7.64648%2029.9265%207.67879%2029.933%207.71142%2029.933H9.54556C9.68007%2029.933%209.78706%2029.826%209.79011%2029.6945C9.85125%2027.3346%2010.7989%2025.1245%2012.4741%2023.4493C14.2073%2021.716%2016.5092%2020.7623%2018.9608%2020.7623C21.4124%2020.7623%2023.7143%2021.716%2025.4475%2023.4493C27.1227%2025.1245%2028.0703%2027.3346%2028.1315%2029.6945C28.1345%2029.829%2028.2415%2029.933%2028.376%2029.933H30.2102C30.2428%2029.933%2030.2751%2029.9265%2030.3052%2029.9138C30.3353%2029.9011%2030.3625%2029.8826%2030.3853%2029.8592C30.4081%2029.8358%2030.426%2029.8082%2030.4379%2029.7778C30.4498%2029.7474%2030.4555%2029.7149%2030.4547%2029.6823C30.4242%2028.2211%2030.1215%2026.7997%2029.5529%2025.4577ZM18.9608%2018.4391C17.5577%2018.4391%2016.2371%2017.8919%2015.2436%2016.8984C14.2501%2015.9049%2013.7029%2014.5843%2013.7029%2013.1812C13.7029%2011.7781%2014.2501%2010.4575%2015.2436%209.46401C16.2371%208.47052%2017.5577%207.92334%2018.9608%207.92334C20.3639%207.92334%2021.6845%208.47052%2022.678%209.46401C23.6715%2010.4575%2024.2187%2011.7781%2024.2187%2013.1812C24.2187%2014.5843%2023.6715%2015.9049%2022.678%2016.8984C21.6845%2017.8919%2020.3639%2018.4391%2018.9608%2018.4391Z'%20fill='white'/%3e%3c/g%3e%3c/svg%3e)
Dr. Haizhou Li
'%3e%3cpath%20d='M22.1642%2019.0924C21.7317%2018.068%2021.1041%2017.1375%2020.3163%2016.3527C19.5309%2015.5656%2018.6006%2014.9381%2017.5766%2014.5048C17.5674%2014.5002%2017.5582%2014.4979%2017.5491%2014.4933C18.9774%2013.4616%2019.9059%2011.7811%2019.9059%209.88504C19.9059%206.74408%2017.3611%204.19922%2014.2201%204.19922C11.0792%204.19922%208.53429%206.74408%208.53429%209.88504C8.53429%2011.7811%209.46282%2013.4616%2010.8912%2014.4956C10.882%2014.5002%2010.8728%2014.5025%2010.8636%2014.5071C9.83652%2014.9404%208.91487%2015.5617%208.1239%2016.355C7.33685%2017.1404%206.70933%2018.0707%206.276%2019.0947C5.85031%2020.0972%205.62072%2021.172%205.59967%2022.2609C5.59905%2022.2853%205.60335%2022.3097%205.61229%2022.3325C5.62123%2022.3553%205.63465%2022.376%205.65174%2022.3935C5.66883%2022.4111%205.68926%2022.425%205.71182%2022.4345C5.73437%2022.444%205.7586%2022.4489%205.78308%2022.4489H7.15868C7.25956%2022.4489%207.3398%2022.3686%207.3421%2022.2701C7.38795%2020.5001%208.09868%2018.8425%209.35506%2017.5861C10.655%2016.2862%2012.3814%2015.5709%2014.2201%2015.5709C16.0588%2015.5709%2017.7852%2016.2862%2019.0852%2017.5861C20.3415%2018.8425%2021.0523%2020.5001%2021.0981%2022.2701C21.1004%2022.3709%2021.1807%2022.4489%2021.2815%2022.4489H22.6571C22.6816%2022.4489%2022.7058%2022.444%2022.7284%2022.4345C22.751%2022.425%2022.7714%2022.4111%2022.7885%2022.3935C22.8056%2022.376%2022.819%2022.3553%2022.8279%2022.3325C22.8369%2022.3097%2022.8412%2022.2853%2022.8406%2022.2609C22.8176%2021.165%2022.5907%2020.0989%2022.1642%2019.0924ZM14.2201%2013.8284C13.1678%2013.8284%2012.1773%2013.418%2011.4322%2012.6729C10.6871%2011.9278%2010.2767%2010.9374%2010.2767%209.88504C10.2767%208.83271%2010.6871%207.84227%2011.4322%207.09715C12.1773%206.35204%2013.1678%205.94165%2014.2201%205.94165C15.2724%205.94165%2016.2629%206.35204%2017.008%207.09715C17.7531%207.84227%2018.1635%208.83271%2018.1635%209.88504C18.1635%2010.9374%2017.7531%2011.9278%2017.008%2012.6729C16.2629%2013.418%2015.2724%2013.8284%2014.2201%2013.8284Z'%20fill='%238590A2'/%3e%3c/g%3e%3c/svg%3e)
Co-authors
Following
Followers
Research Focus & Metrics
Explore full metrics on Scilit
Academic Career Length
8Years (2019-Present)
(Calculated once Scilit publication data is synced: current year − year of first publication + 1)
Representative Publications
View All Publications
Journal Article
XSXiaojuan Sun
Xiaojuan SunHDHongbo Deng
Hongbo DengTSTengyun Shu
Tengyun ShuMXmin xu
min xuLSLi-Hua Su
Li-Hua SuHLHaizhou Li
Haizhou LiPanax notoginseng (Burk.) F. H. is a genuine medicinal material in Yunnan Province. As accessories, P. notoginseng leaves mainly contain protopanaxadiol saponins. The preliminary findings have indicated that P. notoginseng leaves contribute to its significant pharmacological effects and have been administrated to tranquilize and treat cancer and nerve injury. Saponins from P. notoginseng leaves were isolated and purified by different chromatographic methods, and the structures of 1–22 were elucidated mainly through comprehensive analyses of spectroscopic data. Moreover, the SH-SY5Y cells protection bioactivities of all isolated compounds were tested by establishing L-glutamate models for nerve cell injury. As a result, twenty-two saponins, including eight dammarane saponins, namely notoginsenosides SL1-SL8 (1–8), were identified as new compounds, together with fourteen known compounds, namely notoginsenoside NL-A3 (9), ginsenoside Rc (10), gypenoside IX (11), gypenoside XVII (12), notoginsenoside Fc (13), quinquenoside L3 (14), notoginsenoside NL-B1 (15), notoginsenoside NL-C2 (16), notoginsenoside NL-H2 (17), notoginsenoside NL-H1 (18), vina-ginsenoside R13 (19), ginsenoside II (20), majoroside F4 (21), and notoginsenoside LK4 (22). Among them, notoginsenoside SL1 (1), notoginsenoside SL3 (3), notoginsenoside NL-A3 (9), and ginsenoside Rc (10) showed slight protective effects against L-glutamate-induced nerve cell injury (30 µM).
1 September 2019 in Fitoterapia
Journal Article
CGChen Gu
Chen Gu
AYAi-Ping Yin
Ai-Ping Yin
HYHao-Yang Yuan
Hao-Yang Yuan
KYKong Yang
Kong Yang
JLJia Luo
Jia LuoMXmin xu
min xu +4
2 November 2023 in Phytochemistry
Journal Article
YSYu-Ying Song
Yu-Ying SongYZYong-Zhi Zhou
Yong-Zhi Zhou
YWYun-Fen Wang
Yun-Fen Wang
TSTeng-Yun Shu
Teng-Yun ShuYFYang Feng
Yang FengHLHaizhou Li
Haizhou Li +2
Journal Article
RRRui Ren
Rui RenMZMing-Yan Zhang
Ming-Yan ZhangTSTengyun Shu
Tengyun ShuYKYa-Ting Kong
Ya-Ting KongLSLi-Hua Su
Li-Hua SuHLHaizhou Li
Haizhou LiThe fruits of Solanum torvum Swartz, a wild relative of eggplant, are consumed as a wild vegetable in tropical regions of Africa, Asia, and South America. In traditional Chinese medicine, it is believed to have anti-inflammatory and sedative effects. In the Philippines, water decoction is used to treat hyperactivity disorder. Twenty-two steroidal saponins were isolated and purified from the fruits grown in Yunnan, China, including six new compounds: torvosides U–Z (1–6). During drying and cooking, the saponins may undergo transformation, resulting in small amounts of sapogenins. These transformations can include dehydration of hydroxyl groups at position C22, formation of double bonds at position 20, 22 or 22, 23, and even formation of peroxide products. Saponin compounds torvoside X (4), torvoside Y (5), torvoside A (7), and (25S)-3-oxo-5α-spirostan-6α-yl-O-β-d-xylopyranoside (20), which are glycosylated at C-6, showed certain anti-epileptic activity in a pentylenetetrazole-induced zebrafish seizure model. No antiproliferative activity was detected when tested on the cancer cell line HepG2, and no hepatotoxic effect was noted on normal liver cell line LO2.
Journal Article
Alpine plants face intense ultraviolet (UV) radiation in high-altitude ecosystems, necessitating adaptive mechanisms like tyrosinase-mediated phenolic metabolism for UV protection. This study aimed to characterize the phenolic profile of Corallodiscus flabellatus (or C. flabellata) and elucidate its mechanistic interactions with tyrosinase under high-altitude environments with intense ultraviolet (UV) radiation. Two novel phenylethanoid glycosides (PhGs) and seven known compounds were isolated using silica gel, ODS, and preparative HPLC, with structures determined via NMR, HR-ESI-MS, and acid hydrolysis. Tyrosinase (EC 1.14.18.1) inhibition assays revealed divergent effects: compound 7 (containing a caffeoyl moiety) exhibited potent inhibition (IC50 = 0.23 μM), comparable to arbutin, while other PhGs displayed activation or biphasic responses. Molecular docking analysis demonstrated that compound 7 stabilized tyrosinase via π-π stacking with Phe264 and Cu2+ coordination, whereas activating compounds likely acted as substrates. These findings elucidate the dual regulatory function of PhGs, which activate tyrosinase to counteract acute ultraviolet-induced stress and inhibit its activity to attenuate oxidative overload, thereby advancing our understanding of alpine plant adaptation mechanisms.
17 May 2026 in Fitoterapia
Journal Article
LYLi-Ling Yang
Li-Ling Yang
YZYong-Zhi Zhou
Yong-Zhi Zhou
YFYang Feng
Yang Feng
LSLi-Hua Su
Li-Hua SuHLHaizhou Li
Haizhou LiAbout Me
Haizhou, Li is a professor who graduated from Nankai University in 1997 and majored in biochemistry. In 2000, he obtained his Master of Science in Phytochemistry from Kunming Institute of Botany, Chinese Academy of Sciences, where also researched natural products chemistry, standards for medicinal materials, and new drug research and development. He then studied Natural Medicine Chemistry in the Pharmaceutical Department of Nagasaki University in 2004. In 2008, he obtained a Doctor of Pharmacy. After that, he was introduced to the Faculty of Life Science and Technology, Kunming University of Science and Technology, engaging in teaching and scientific research related to traditional Chinese medicine. His research focuses on the chemical composition, physiological activity, production process, and quality control of medicinal plants (Chinese medicinal materials). Specific work includes extraction, separation, structure identification, clarifying the efficacy and toxicity of traditional Chinese medicine, and establishing qualitative standards. He won the Yunnan Province Science and Technology Progress Award in 2003, has published over 30 academic papers (including 20 SCI indexes), and applied for 5 patents. At present, he presides two projects of the National Natural Science Foundation of China, and one project at the Natural Science Foundation of Yunnan Province. His research interests include the chemistry of Chinese medicines and the modernization of Chinese medicines.